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Surana A.S.,Columbia Institute of Pharmacy
International Journal of Pharmaceutical Sciences Review and Research | Year: 2010

In recent years scientific and technological advancements have been made in the research and development of oral drug delivery system. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. Chewing gum is one of the very popular oral confectionery products. Chewing gum is a combination of a water-insoluble phase, known as gum base (insoluble gum base resin), elastomers, emulsifiers, fillers, waxes, antioxidants, softeners, sweeteners, food colourings, flavoring agents, and in case of medical chewing gum, active substances. It offers various advantages over conventional drug delivery system. The manufacturing process of chewing gum takes from 5-15 min, but longer mixing time may be depending on the texture and function of gum base used. An In-vitro apparatus was specially designed and constructed for release testing of medicated chewing gums. The absorption of active substances through the buccal mucosa can be examined by both In-vitro and In-vivo methods. It was concluded that Chewing gum is an excellent drug delivery system for self-medication as it is convenient and can be administered discreetly without water.

Singh V.K.,Columbia Institute of Pharmacy | Subudhi B.B.,Siksha O' Anusandhan University
Medicinal Chemistry Research | Year: 2015

Poor permeability of methotrexate across blood brain barrier limits its scope for application against brain cancer. Glutamine is transported to brain actively by multiple amino acid transporters and protects against complications of chemotherapy. To use glutamine as a carrier, a reversible conjugate of methotrexate was developed with structural features of glutamine. This was stable and released methotrexate effectively. The brain uptake was enhanced significantly. © 2014 Springer Science+Business Media New York.

Satapathy T.,Columbia Institute of Pharmacy | Panda P.K.,Utkal University
Research Journal of Pharmacy and Technology | Year: 2013

Gastro esophageal reflux disease (GERD) is a common chronic disorder that is associated with a huge economic burden in the many countries and significantly decreased quality of life. Nearly all epidemiologic studies have found an association between increasing body mass index (BMI) and symptoms of gastro esophageal reflux disease (GERD). Changes in gastro esophageal anatomy and physiology caused by obesity may explain the association. These include an increased prevalence of esophageal motor disorders, diminished lower esophageal sphincter (LES) pressure, the development of a hiatal hernia, and increased intragastric pressure. GERD can lead to complications that include esophageal stricture and esophageal adenocarcinoma. Multiple challenges are associated with GERD treatment. First, lack of symptoms does not correlate with the absence of or the healing of esophageal lesions. Second, proton pump inhibitors, the current standard of care for GERD, are ineffective for the majority of GERD patients who have nonerosive disease. Investigations and technical advances have enhanced our understanding and management of gastro esophageal reflux disease. The recognition of the prevalence and importance of patients with endoscopy-negative reflux disease as well as those refractory to proton pump inhibitor therapy have led to an increasing need for objective tests of esophageal reflux. This review focuses on the various multicultural issues in the epidemiology, pathophysiology, diagnosis, and treatment of GERD. © RJPT All right reserved.

Subudhi B.B.,Siksha O' Anusandhan University | Singh V.K.,Columbia Institute of Pharmacy
Anti-Cancer Agents in Medicinal Chemistry | Year: 2016

Treatment of brain tumour is a major challenge. This is mainly because of the limited bioavailability of chemotherapeutics in the brain. The major hurdle for brain availability of anticancer agents is the blood brain barrier (BBB). BBB is supposed to protect the brain and maintain homeostasis. It allows vital nutrient for normal brain function and effluxes out foreign toxic substance. Advance in knowledge of bidirectional movement across BBB has allowed development of strategies to enhance brain availability of chemotherapeutics for management of brain tumour. In this review we have focussed on various approaches adopted for enhancing delivery of anticancer agents. We have given a critical analysis of the approaches for further research © 2016 Bentham Science Publishers.

Roy A.,Columbia Institute of Pharmacy | Prasad P.,Columbia Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2013

Mushrooms are known for their nutritional and culinary values and used as medicines by humans for centuries. They are also known for their high quality proteins, vitamins, fibres and thus called as "nutraceuticals". The chemical nature of the bioactive compounds present in this mushroom includes: polysaccharides, lipopolysaccharides, proteins, peptides, glycoproteins, nucleosides, lipids and their derivatives. Mushrooms are one of the prominent functional food, rich in protein but also as a source of biologically active compounds of medicinal values which include medicine/dietary supplements for anticancer, antiviral, hypotensive, immunomodulatory agent and many others. Pleurotus ostreatus possesses many medicinal properties and also used as health promoter. It is gaining more importance than any other mushrooms as therapeutic agent and for health benefits. In the present paper the medicinal properties of Pleurotus ostreatus is being discussed. © RJPT.

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