Kirov Military Medical Academy

Saint Petersburg, Russia

Kirov Military Medical Academy

Saint Petersburg, Russia
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PubMed | Russian National Research Medical University, Neurology Research Center, JSC BIOCAD, Vladimirsky Moscow Regional Research Clinical Institute and 5 more.
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2017

The article presents the results of international multicenter randomized double-blind, active and placebo-controlled, comparative phase 3 trial. The goal of the study was to demonstrate non-inferiority of BCD-063 (glatiramer acetate, manufactured by JSC BIOCAD, Russia) to copaxone-Teva (Teva Pharmaceutical Enterprise Co., Ltd., Israel) in patients with relapsing-remitting multiple sclerosis.158 patients with relapsing-remitting multiple sclerosis were randomly assigned into 3 groups: BCD-063, copaxone-Teva and placebo, at a ratio of 2:2:1, respectively.Efficacy analysis after 48 weeks of therapy demonstrated no differences between BCD-063 group and copaxone-Teva group in both MRI parameters and frequency of relapses. The mean (SD) of number of MRI-confirmed relapses per patient per year (the primary endpoint) in BCD-063 group was 0.098361 (0.351422), in copaxone-Teva group - 0.098361 (0, 351 422) and in placebo group - 0.178571 (0.390021). There were also no differences between the groups for all other efficacy parameters (EDSS and MSFC). Both investigational BCD-063 and copaxone-Teva demonstrated a favorable safety profile. The data obtained from the present study confirm the therapeutic equivalence of BCD-063 (CJSC BIOCAD, Russia) and copaxone-Teva, that is important for further implementation of glatiramer acetate generic in the clinical practice of multiple sclerosis therapy.


Andreev V.P.,Herzen State Pedagogical University | Maslov Y.I.,Saint Petersburg State University | Sorokoletova E.F.,Kirov Military Medical Academy
Russian Journal of Plant Physiology | Year: 2012

Three species of Fucus inhabiting different zones at the littoral and sublittoral of the White Sea (F. vesiculosus L., F. serratus L., and F. distichus L.) were compared with regard to performance of the photosynthetic apparatus (PSA) and PSA changes upon prolonged desiccation of algae. The content of chlorophyll a and the total content of carotenoids were significantly higher in F. serratus than in F. vesiculosus. The potential quantum yield (F v/F m) of photosystem II (PSII) was 0.69-0.74 in all species. The highest effective quantum yield of PSII (Y II) was observed in F. vesiculosus plants inhabiting zones with the most intense insolation. The ratio of non-photochemical quenching to photochemical quenching (qN/qP) increased with the depth of algal habitats in the row from F. vesiculosus to F. serratus. The fluorescence parameters F. serratus deviated during desiccation from their normal values and did not recover upon the subsequent return to water. By contrast, the fluorescence parameters of F. vesiculosus and F. distichus recovered gradually after the return of algae from air to sea water. It is supposed that F. serratus plants, unlike other species, are characterized by comparatively low physiological plasticity. © 2012 Pleiades Publishing, Ltd.


PubMed | Medical Center Admiralteyskie Verfi and Kirov Military Medical Academy
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2016

To evaluate the cognitive changes in patients with mild to moderate Alzheimers disease after the treatment with acetylcholinesterase inhibitors - neuromidin and galantamine.Fifty-eight patients with probable Alzheimers disease, aged 60-84 years (mean 73.26.7), were enrolled in a 20-week double-blind parallel group study. All patients were randomized in 2 groups: group 1 (n=28) received neuromidin, group 2 (n=30) - galantamine. Treatment efficacy was evaluated with the ADAS-cog/11 scale.Both drugs significantly improved or stabilized cognitive function in the patients. The most marked changes were obtained in the group of patients treated with neuromidin (<0.05).The results suggest that the effectiveness of anticholinesterase treatment of Alzheimers disease could be determined not only by the central but also peripheral cholinergic action.


PubMed | St. Petersburg State Medical University, North State Medical University and Kirov Military Medical Academy
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2016

Learning cycle sleep-wake is of great theoretical and practical importance because it allows to understand the general patterns of adaptive mechanisms of human interaction with the environment (neuroplasticity), violations of which are the basis of many diseases of the CNS, including epilepsy.Complex clinical and electroencephalographic (video-EEG monitoring with mandatory recording of sleep) study was carried out before and after prolonged sleep deprivation (for at least 1 day) of 178 patients with locally due to epilepsy (LEi). 45 healthy volunteers were examined in the control group as well as the patients with epilepsy. The work was carried out to compare the results of clinical and neurological and electrophysiological studies during sleep deprivation (SD) in patients with LEi and in healthy individuals with neurohistological and electron microscopic patterns of changes in the brain of rats in an experiment with 48-hour SD.Discovered in the CNS of rats after SD morphological changes such as pleyokoniya of mitochondria, damage in the blood-brain barrier, signs of exhaustion astrocytes, glial cells and the change of the nuclei of gliocytes and some neurons of the type of apoptosis and karyorrhexis and destruction of synapses reveal a violation of the fundamental mechanisms of neuroplasticity. The results allow us to consider the SD patients as a damaging factor for the central nervous system, provoking the development of epileptic seizures and epilepsy, and the SD in laboratory animals can be used as a model for further study of the mechanisms of neuroplasticity. In addition the findings greatly complement current understanding of the mechanisms of neuroplasticity and pathogenesis of epilepsy, and justify the need for the study of therapeutic efficacy of modulators of neuroplasticity (transcranial magnetic stimulation, ipidacrin etc.) in the complexe treatment of patients with the this specified profile.


Elizarov A.Y.,RAS Ioffe Physical - Technical Institute | Levshankov A.I.,Kirov Military Medical Academy
Technical Physics | Year: 2011

Interaction between inhalational anesthetic sevoflurane and an absorber of CO2 (soda lime) in the breathing circuit of an anesthesia machine during low-flow anesthesia (0.5 l of a fresh gaseous mixture per minute) is studied with the mass-spectrometric method. Monitoring data for the concentration of sevoflurane and three toxic products of sevoflurane decompositions (substances A, B, and C) during anesthesia in the inspiration-expiration regime are presented. The highest concentration of substance A is found to be 65 ppm. The biochemical blood analysis before and after anesthesia shows that nephropathy is related to the function of liver toxicity. It is found that inhalational anesthetic sevoflurane influences the concentration of intravenous hypnotic propofol in blood. © 2011 Pleiades Publishing, Ltd.


Bazilevich S.N.,Kirov Military Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

Cryptogenic epilepsy (epilepsy with no obvious cause) is the most common form of the disease in adults. The author discuss clinical- electroencephalographic, neuroimaging (magnetic resonance tomography, positron emission tomography, proton magnetic resonance spectroscopy, diffusion tensor magnetic resonance tomography) and treatment aspects of 70 patients with cryptogenic epilepsy. A dynamic study of patients using neuroimaging methods allowed to single out two groups of patients differed by the course, outcome and treatment. The author suggests hypotheses on the explanation of processes underlying epilepsy with no obvious cause.


Gofman V.R.,Kirov Military Medical Academy | Milkov A.A.,Kirov Military Medical Academy
Human Physiology | Year: 2011

The relationships between the incidence of hearing loss and concomitant pathologies in the civil flight personnel and individual sensitivity of the auditory analyzer to aviation noise and length of service was investigated using two-way analysis of variance (ANOVA) without repetition. In the sample examined, 335 subjects (group 1) had only the audiometric traces of noise impact on the auditory analyzer, and 108 subjects (group 2) displayed sustained loss of hearing (chronic sensorineural hearing loss). In the aggregate, the obtained results evidence that only the indicators of change in the incidence of cardiovascular diseases (atherosclerosis of the aorta and coronary arteries, atherosclerotic cardiosclerosis) and sensorineural hearing loss depend on the individual sensitivity to noise and length of flight service. In the remaining cases, none of the factor criteria was the only cause of the pathology under consideration. The proportion of causative factors in the formation of health disorders varies in both the type of a non-auditory pathology and periods of flight service; there are also consistent patterns of the time of incipient hearing loss. The flight personnel from group 2 with the low noise sensitivity and sustained deafness were diagnosed to have a broader variety of extra-aural pathologies than the subjects from group 1 with incipient hearing disorders. ANOVA without repetition is applicable to evaluation of the impact of unfavorable flight factors on the formation of different types of somatic pathologies. © 2011 Pleiades Publishing, Ltd.


Lobzin V.Y.,Kirov Military Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2015

Objective — to study cognitive function, CSF biochemical markers of amyloidosis and neurodegeneration, cerebral metabolism using PET, cerebral volumetric changes and metabolic content of the cingular gyrus using magnetic resonance spectroscopy (MRS) in patients with amnesic and neurodynamic variants of mild cognitive impairment (MCI). Material and methods. Authors examined 369 patients with cognitive impairment of different severity. All patients underwent neuropsychological examination. To determine the levels of β-amyloid and tau-protein,a lumbar puncture was performed in 125 patients and 20 controls. 18-Fluorine deoxyglucose positron emission tomography (FCSRT) was performed in 77 patients. Assessment of metabolite levels by MRS and volumetric parameters by magnetic resonance morphometry was done in 92 patients. Results and conclusion. The «free and cued selective reminding test» and «trail making test» showed the best diagnostic value in the early differential diagnosis of amnesic and neurodynamic variants of MCI. A decrease in beta-amyloid-42 protein and an increase in tau-protein in CSF are early markers of neurodegenerative dementia as well as of the additional involvement of the neurodegeneration in cerebrovascular disease. Specific areas of glucose hypometabolism on preclinical stages of dementia were identified using FCSRT. Spectroscopy and morphometry based on magnetic resonance can predict neurodegeneration in the cingular cortex, frontal and temporal brain. © 2015, Media Sphera. All Rights Reserved.


PubMed | Kirov Military Medical Academy
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2016

To study cognitive function, CSF biochemical markers of amyloidosis and neurodegeneration, cerebral metabolism using PET, cerebral volumetric changes and metabolic content of the cingular gyrus using magnetic resonance spectroscopy (MRS) in patients with amnesic and neurodynamic variants of mild cognitive impairment (MCI).Authors examined 369 patients with cognitive impairment of different severity. All patients underwent neuropsychological examination. To deter-mine the levels of -amyloid and tau-protein,a lumbar puncture was performed in 125 patients and 20 controls. 18-Fluorine deoxyglucose positron emission tomography (FCSRT) was performed in 77 patients. Assessment of metabolite levels by MRS and volumetric parameters by magnetic resonance morphometry was done in 92 patients.The free and cued selective reminding test and trail making test showed the best diagnostic value in the early differential diagnosis of amnesic and neurodynamic variants of MCI. A decrease in beta-amyloid-42 protein and an increase in tau-protein in CSF are early markers of neurodegenerative dementia as well as of the additional involvement of the neurodegeneration in cerebrovascular disease. Specific areas of glucose hypometabolism on preclinical stages of dementia were identified using FCSRT. Spectroscopy and morphometry based on magnetic resonance can predict neurodegeneration in the cingular cortex, frontal and temporal brain.


PubMed | Kirov Military Medical Academy
Type: Journal Article | Journal: Journal of glaucoma | Year: 2016

To investigate latent conjunctival Chlamydia trachomatis (CT) and Bacteroides fragilis (BF) infections as potential risk factors for posttrabeculectomy bleb failure.This retrospective observational study included 50 primary open-angle glaucoma eyes of 50 patients who were submitted to trabeculectomy without cytostatics from September 2010 to June 2011 and were followed up for at least a year. Preoperatively, conjunctival scrapings were taken and their specimens subjected to polymerase chain reaction, direct fluorescent assay and cell culture testing for CT, and culture for BF on blood agar medium. Serum CT-specific IgG and IgA and tear interleukin (IL)-1 and IL-8 concentrations were measured with enzyme-linked immunosorbent assay. We defined bleb failure as intraocular pressure >21 mm Hg with antiglaucoma medications, resulting from reduced bleb filtration capacity due to bleb fibrosis, fistula obstruction, flattened bleb, or encapsulated bleb, and no earlier than 2 weeks after surgery. At the time of the reintervention, a scleroconjunctival biopsy was obtained for histopathology (including direct fluorescent assay testing for CT). Eyes were divided into a failure group and a nonfailure group, depending on whether they developed bleb failure (required reintervention) or not within a follow-up year.In the failure group (n=18), the frequencies of detection of CT and BF in conjunctival specimens were 27.8% and 66.7%, respectively, versus 0% and 9.4% in the nonfailure group (n=32). CT and BF were detected in 11.1% and 11.1%, respectively, of scleroconjunctival biopsies. IgG and IgA seropositivity to CT was found in 66.7% and 33.3%, respectively, of the failure group patients, versus 9.4% and 0% of the nonfailure group patients. Tear IL-1 and IL-8 levels were markedly elevated in the failure group (468.8380.43 and 107.8915.11 pg/mL, respectively) versus the nonfailure group (22.345.43 and 9.342.83 pg/mL, respectively).Being a contributor to low-grade conjunctival inflammation, latent conjunctival CT, and BF infections in primary open-angle glaucoma patients represent risk factors for posttrabeculectomy bleb failure.

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