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Aachen, Germany

RWTH Aachen University is a research university of technology located in Aachen, North Rhine-Westphalia, Germany. With over 40,000 students enrolled in 130 study programs, it is the largest technical university in Germany. The institution maintains close links to industry and accounts for the highest amount of third-party funds of all German universities in both absolute and relative terms per faculty member.In 2007, RWTH Aachen was chosen by DFG as one of nine German Universities of Excellence for its future concept RWTH 2020: Meeting Global Challenges and additionally won funding for one graduate school and three clusters of excellence. In 2012, RWTH Aachen was selected again as a University of Excellence and altogether financially endowed for one graduate school and two clusters of excellence. RWTH Aachen is one of only six German universities to retain this status from the previous funding period of 2007 - 2012.RWTH Aachen is a founding member of IDEA League, a strategic alliance of five leading universities of technology in Europe. The university is also a member of TU9, DFG and the Top Industrial Managers for Europe network. Wikipedia.

Feijs K.L.,RWTH Aachen
Nature reviews. Molecular cell biology | Year: 2013

ADP-ribosylation of proteins was first described in the early 1960's, and today the function and regulation of poly(ADP-ribosyl)ation (PARylation) is partially understood. By contrast, little is known about intracellular mono(ADP-ribosyl)ation (MARylation) by ADP-ribosyl transferase (ART) enzymes, such as ARTD10. Recent findings indicate that MARylation regulates signalling and transcription by modifying key components in these processes. Emerging evidence also suggests that specific macrodomain-containing proteins, including ARTD8, macroD1, macroD2 and C6orf130, which are distinct from those affecting PARylation, interact with MARylation on target proteins to 'read' and 'erase' this modification. Thus, studying macrodomain-containing proteins is key to understanding the function and regulation of MARylation.

The combination of the advantageous properties of molecular and solid catalysts is considered the "Holy Grail" in catalysis research. Great potential is provided by nanoporous polymers. Chemically well-defined moieties in combination with a high stability render these materials suitable as catalyst supports for liquid-phase and even aqueous-phase catalytic processes, especially regarding the transition from fossil resources to renewable resources. In this Minireview, recent developments are summarized, covering the three main approaches: solid metal-free organocatalysts, immobilized molecular catalyst species, and supported metal nanoparticles and clusters. Their potential is evaluated and the question as to whether nanoporous polymers can bridge the gap between homogeneous and heterogeneous catalysis is critically discussed. Poring over polymers: Nanoporous polymers pose great potential for the future development of catalytic processes. They unite the advantages of homogeneous and heterogeneous processing by providing solid organocatalysts, immobilized molecular metal species, and stabilized metal nanoparticles and clusters. Recent developments in these three main areas are summarized. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keim W.,RWTH Aachen
Angewandte Chemie - International Edition | Year: 2013

Luck, talent, and hard work: Currently, over a million tons of α-olefins are manufactured per annum using the Shell Higher Olefin Process (SHOP). The discovery of the process was the result of correct model conceptions and lucky coincidence. W. Keim, one of the main participants in the development of SHOP, gives a personal account of the events. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Conrath U.,RWTH Aachen
Trends in Plant Science | Year: 2011

Plants can be primed for more rapid and robust activation of defence to biotic or abiotic stress. Priming follows perception of molecular patterns of microbes or plants, recognition of pathogen-derived effectors or colonisation by beneficial microbes. However the process can also be induced by treatment with some natural or synthetic compounds and wounding. The primed mobilization of defence is often associated with development of immunity and stress tolerance. Although the phenomenon has been known for decades, the molecular basis of priming is poorly understood. Here, I summarize recent progress made in unravelling molecular aspects of defence priming that is the accumulation of dormant mitogen-activated protein kinases, chromatin modifications and alterations of primary metabolism. © 2011 Elsevier Ltd.

Walther A.,RWTH Aachen | Muller A.H.E.,Johannes Gutenberg University Mainz
Chemical Reviews | Year: 2013

Some of the advancements in the field of non-centrosymmetric Janus particles (JP) along with the synthesis, self-assembly behavior, physical properties, and applications, are discussed. Researchers focus on describing biological, biobased, and bioinspired JPs, access routes based on classical organic synthesis, along with macromolecular engineering and self-assembly of polymers, symmetry breaking at interfaces, selective growth of second compartments, and symmetry-breaking in confined volumes. The researchers also discuss related techniques using the break-up or patterning of side-by-side flown liquids, and miscellaneous techniques. They inform that significant progress has been made in diversifying synthetic strategies for the preparation of JPs over a period of time with the aim to include diverse functionalities, target inorganic or organic hybrid materials, along with finding ways toward a scale-up.

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