Rv Northland Institute

Dādri, India

Rv Northland Institute

Dādri, India
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Agnihotri A.,RV Northland Institute | Singh V.,P.A. College
Acta Poloniae Pharmaceutica - Drug Research | Year: 2013

Tamarindus indica and Cassia fistula are traditionally important medicinal plants. Stem barks of these plants have not been much explored for their potential hypoglycemic and oxidative stress conditions. The main aim of present study was to evaluate antidiabetic activity along with renal complications and antioxidant potential of alcoholic extracts of stem barks of these plants. Alcoholic extracts of stem barks of Tamarindus indica and Cassia fistula were evaluated for anti-hyperglycemic effect in alloxan-induced diabetic rats. Biochemical parameters including blood glucose, serum cholesterol, triglycerides, serum albumin, total protein and creatinine were studied. Antioxidant potential in DPPH, nitric oxide and hydroxyl radical induced in vitro assay methods were evaluated. Acute toxicity studies were carried out to establish the safety of the drugs according to OECD guidelines. There was a significant decrease in blood glucose level in diabetic rats treated with the alcoholic extracts of both plants. Serum cholesterol, serum triglyceride, serum creatinine, serum albumin, total proteins and body weight were recovered to normal levels at the end of the studies. Alcoholic extract of stem bark of both plants showed significant antioxidant activity in DPPH, nitric oxide and hydroxyl radical induced in vitro assay methods. Acute toxicity studies with the extracts of both plants showed no signs of toxicity up to a dose level of 2000 mg/p.o. It can be concluded from the study that Tamarindus indica and Cassia fistula stem barks possess blood glucose lowering effect along with antioxidant effect and protective effect on renal complications associated with hyperglycemia.


Bhardwaj V.,Singhania University | Harit G.,Wockhardt Research Center | Kumar S.,Rv Northland Institute
International Journal of Drug Development and Research | Year: 2012

Controlled release drug delivery System (CRDDS) is the major aspect of research in twentieth century into which Interpenetrating polymer network (IPN) based drug delivery system paying the important role in delivering the drug at predetermined rate. IPN is considered as one of the most useful novel biomaterial. Its biocompatible and biodegradable properties made this biomaterial as a novel excipient in the pharmaceutical industry. These systems are also used for tissue engineering such as cartilage scaffolds, bone substitutes etc. The excellent physiochemical attributes such as providing stability to the formulations, improves solubility of hydrophobic drugs, excellent swelling capacity and its biodegradability, impart bioavailability, drug targeting in a specific tissue and very weak antigenecity, made IPN the primary resource in both pharmaceutical and medical applications. IPN offers novel ways to formulator to formulate multiparticulate drug delivery system, tablets or transdermal delivery systems. IPN is highly effective for controlling the drug release of Biopharmaceutics Classification System (BCS) class I drugs. © 2012 IJDDR.


Gupta G.,Rv Northland Institute | Singh A.,Rv Northland Institute
International Journal of PharmTech Research | Year: 2012

Technological attempts have been made in the research and development of rate-controlled oral drug delivery systems to overcome physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Conventional oral dosage forms pose low bioavailability problems due to their rapid gastric transition from stomach, especially in case of drugs which are less soluble at alkaline pH of intestine. Similarly, drugs which produce their local action in stomach get rapidly emptied and do not get enough residence time in stomach. So, frequency of dose administration in such cases is increased. To avoid this problem, various efforts have been made to prolong the retention time of drug delivery system. In this review, we will discuss about the various approaches to produce gastro retention of drug delivery system, with current & recent developments of Stomach Specific floating drug delivery system.


Sultana S.,Rv Northland Institute | Khan M.R.,Rv Northland Institute | Kumar M.,Rv Northland Institute | Kumar S.,Rv Northland Institute | Ali M.,Jamia Hamdard University
Journal of Drug Targeting | Year: 2013

Cancer has become the leading cause of death among different populations of the world. The treatment is limited to chemotherapy, radiation, and surgery. Selective targeting to the tumor cells is possible by nanoparticles-based drug delivery system. It maximizes the drug concentration at the desired target and protects the surrounding healthy tissues at the same time. To improve the targeting potential of the anticancer drugs, nanoparticles were optimized for the size and surface characteristics to enhance their circulation time and targeting efficiency. Passive targeting involves surface modification with polyethylene glycol to avoid its elimination by natural body defense mechanism. Active targeting involves chemical interaction with certain antigen, receptors, and genes which are over expressed during progression of disease. In addition, the article highlights recent developments in "smart"-stimulus- responsive-drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug. Enhanced targeting potential, imaging, and controlled release of drugs or therapeutic molecules could be possible through multi-functional nanocarrier. Such multi-faceted, versatile nanocarriers and drug delivery systems promise a substantial increase in the efficacy of diagnostic and therapeutic applications in pharmaceutical sciences. © 2013 Informa UK, Ltd.


Sultana S.,Jamia Hamdard University | Talegaonkar S.,Jamia Hamdard University | Singh D.,Bundelkhand University | Ahmad R.,Rv Northland Institute | And 3 more authors.
Saudi Pharmaceutical Journal | Year: 2013

The present work deals with various attempts to prepare a gastroretentive formulation of lacidipine for treating gastroparesis. High density sucrose beads were modified by coating with certain polymers, but unfortunately sustained release could not be achieved. Granules were prepared by wet granulation technology using different combinations of polymers and a release of the drug was observed. The method failed to release the drug as per desired specifications. Polymeric coating followed by wet granulation was thought to be a better process to sustain thedissolution rate. The release rate can be modified by the incorporation of different polymeric coatings, but the mucoadhesive potential of granules was only 4.23% which might be due to its large size and the presence of other ingredients. Further, the lacidipine loaded microparticles were prepared by different methods such as compression, ionic gelation with TPP, ionic gelation with TPP and glutaraldehyde, spray drying and coacervation techniques. The formulations were evaluated for average particle size, surface morphology, entrapment efficiency, % yield and mucoadhesive potential. The microparticles prepared by compression method using HPMC K4M and SCMC as mucoadhesive polymers and BaSO4 as high density diluent showed poor bioadhesion (8.3%) and poor release characteristics (100% in 120min). Ionic gelation with tripolyphosphate yielded microspheres with poor mechanical strength. In order to improve its mechanical strength, TPP ionic gelation was combined with step-wise cross-linking with glutaraldehyde. The additional solidification step to improve mechanical strength left this procedure tedious, time consuming and cytotoxic. Spray drying method gave a very low yield with 46.67% bioadhesion. The method using CaCl2 for ionotropic gelation showed the best results with regard to physical characteristics (well formed discrete, spherical surface microcapsule), particle size (88.57±0.51), in vitro bioadhesion (67.33%), yield (85%) and loading (70%). © 2013.


Zahak A.,Rv Northland Institute | Akhtar M.S.,Najran University | Mohsin N.,Najran University | Ahamd M.Z.,Najran University | And 2 more authors.
Current Drug Therapy | Year: 2015

Chronic liver disease (such as hepatitis) is a major health problem worldwide, especially in developing countries. Despite the tremendous advancements in modern medicine, there is no effective drug available that stimulates liver function. The search of new drugs to protect hepatic injury has been of recent interest. The use of natural remedies for the treatment of liver disease has a long history and medicinal plants and their derivatives are still used all over the world. Nigella sativa is used as analgesic, antiinflammatory, anti-diarrhoeal, antimicrobial, anticancer, immunomodulator, bronchodilator, and also said to be hepatoprotective. The aim of this work is to evaluate the hepatoprotective activity of Nigella sativa in Wistar rats and to bring about scientific justification for the use of this drug in hepatitis. Healthy male Wistar rats were treated with the extract of Nigella sativa for 14 days and on day 14 hepatotoxicity was induced by the administration of D-galactosamine through Intraperitoneal (IP) route, blood was collected and analyzed for various biochemical parameters, animals were sacrificed for histopathology, and were compared with the effect of Silymarine as a standard drug. The substantially elevated levels of aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and albumin were restored significantly by the extract of Nigella sativa. The histological studies supported these findings. From the present study it can be concluded that, the extract of Nigella sativa has appreciable hepatoprotective potential. © 2015 Bentham Science Publishers.


Gupta R.,Rv Northland Institute | Kumar M.,Rv Northland Institute | Kumar S.,Rv Northland Institute | Singh S.P.,Rv Northland Institute
International Journal of Pharma and Bio Sciences | Year: 2014

Liver disorder may cause liver inflammation or tissue injury and affects liver physiologic condition. Natural products that are found in the form of vegetables, fruits, plant extract, herbs, and animals, have been traditionally and clinically used for treating liver disorders. They are specific chemical compounds that usually have biological activities for use in drug evaluation and design. Many herbal products have been clinically available as potent anti-hepatotoxic agents against commonly occurring liver disorders. This review summarizes the current progress in the basic, clinical, and traditional research on herbal products in treatment of various liver disorders. Also, we will rivet on the discovery and biological evaluation of the herbal products, which shows potential as a new anti-hepatotoxic agent of liver disorders.


PubMed | P.A. College and RV Northland Institute
Type: Journal Article | Journal: Acta poloniae pharmaceutica | Year: 2014

Tamarindus indica and Cassia fistula are traditionally important medicinal plants. Stem barks of these plants have not been much explored for their potential hypoglycemic and oxidative stress conditions. The main aim of present study was to evaluate antidiabetic activity along with renal complications and antioxidant potential of alcoholic extracts of stem barks of these plants. Alcoholic extracts of stem barks of Tamarindus indica and Cassia fistula were evaluated for anti-hyperglycemic effect in alloxan-induced diabetic rats. Biochemical parameters including blood glucose, serum cholesterol, triglycerides, serum albumin, total protein and creatinine were studied. Antioxidant potential in DPPH, nitric oxide and hydroxyl radical induced in vitro assay methods were evaluated. Acute toxicity studies were carried out to establish the safety of the drugs according to OECD guidelines. There was a significant decrease in blood glucose level in diabetic rats treated with the alcoholic extracts of both plants. Serum cholesterol, serum triglyceride, serum creatinine, serum albumin, total proteins and body weight were recovered to normal levels at the end of the studies. Alcoholic extract of stem bark of both plants showed significant antioxidant activity in DPPH, nitric oxide and hydroxyl radical induced in vitro assay methods. Acute toxicity studies with the extracts of both plants showed no signs of toxicity up to a dose level of 2000 mg/p.o. It can be concluded from the study that Tamarindus indica and Cassia fistula stem barks possess blood glucose lowering effect along with antioxidant effect and protective effect on renal complications associated with hyperglycemia.

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