Zahak A.,Rv Northland Institute |
Akhtar M.S.,Najran University |
Mohsin N.,Najran University |
Ahamd M.Z.,Najran University |
And 2 more authors.
Current Drug Therapy | Year: 2015
Chronic liver disease (such as hepatitis) is a major health problem worldwide, especially in developing countries. Despite the tremendous advancements in modern medicine, there is no effective drug available that stimulates liver function. The search of new drugs to protect hepatic injury has been of recent interest. The use of natural remedies for the treatment of liver disease has a long history and medicinal plants and their derivatives are still used all over the world. Nigella sativa is used as analgesic, antiinflammatory, anti-diarrhoeal, antimicrobial, anticancer, immunomodulator, bronchodilator, and also said to be hepatoprotective. The aim of this work is to evaluate the hepatoprotective activity of Nigella sativa in Wistar rats and to bring about scientific justification for the use of this drug in hepatitis. Healthy male Wistar rats were treated with the extract of Nigella sativa for 14 days and on day 14 hepatotoxicity was induced by the administration of D-galactosamine through Intraperitoneal (IP) route, blood was collected and analyzed for various biochemical parameters, animals were sacrificed for histopathology, and were compared with the effect of Silymarine as a standard drug. The substantially elevated levels of aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and albumin were restored significantly by the extract of Nigella sativa. The histological studies supported these findings. From the present study it can be concluded that, the extract of Nigella sativa has appreciable hepatoprotective potential. © 2015 Bentham Science Publishers.
Gupta R.,Rv Northland Institute |
Kumar M.,Rv Northland Institute |
Kumar S.,Rv Northland Institute |
Singh S.P.,Rv Northland Institute
International Journal of Pharma and Bio Sciences | Year: 2014
Liver disorder may cause liver inflammation or tissue injury and affects liver physiologic condition. Natural products that are found in the form of vegetables, fruits, plant extract, herbs, and animals, have been traditionally and clinically used for treating liver disorders. They are specific chemical compounds that usually have biological activities for use in drug evaluation and design. Many herbal products have been clinically available as potent anti-hepatotoxic agents against commonly occurring liver disorders. This review summarizes the current progress in the basic, clinical, and traditional research on herbal products in treatment of various liver disorders. Also, we will rivet on the discovery and biological evaluation of the herbal products, which shows potential as a new anti-hepatotoxic agent of liver disorders.
PubMed | P.A. College and RV Northland Institute
Type: Journal Article | Journal: Acta poloniae pharmaceutica | Year: 2014
Tamarindus indica and Cassia fistula are traditionally important medicinal plants. Stem barks of these plants have not been much explored for their potential hypoglycemic and oxidative stress conditions. The main aim of present study was to evaluate antidiabetic activity along with renal complications and antioxidant potential of alcoholic extracts of stem barks of these plants. Alcoholic extracts of stem barks of Tamarindus indica and Cassia fistula were evaluated for anti-hyperglycemic effect in alloxan-induced diabetic rats. Biochemical parameters including blood glucose, serum cholesterol, triglycerides, serum albumin, total protein and creatinine were studied. Antioxidant potential in DPPH, nitric oxide and hydroxyl radical induced in vitro assay methods were evaluated. Acute toxicity studies were carried out to establish the safety of the drugs according to OECD guidelines. There was a significant decrease in blood glucose level in diabetic rats treated with the alcoholic extracts of both plants. Serum cholesterol, serum triglyceride, serum creatinine, serum albumin, total proteins and body weight were recovered to normal levels at the end of the studies. Alcoholic extract of stem bark of both plants showed significant antioxidant activity in DPPH, nitric oxide and hydroxyl radical induced in vitro assay methods. Acute toxicity studies with the extracts of both plants showed no signs of toxicity up to a dose level of 2000 mg/p.o. It can be concluded from the study that Tamarindus indica and Cassia fistula stem barks possess blood glucose lowering effect along with antioxidant effect and protective effect on renal complications associated with hyperglycemia.