Russian State Social University
Moscow, Russia

Russian State Social University is a public university located in Moscow, Russian Federation. Wikipedia.

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Kislyakov P.A.,Russian State Social University
Human Ecology | Year: 2017

In the article actualized the problem of human ecology in modern conditions. The main study approaches of environmental psychology “man-environment” relationship have been generalized. Educational environment as a set of spatially-objective, social, information, psychological and pedagogical influences and conditions of personality formation serves as an object of the analysis. The risk factors that negatively affect the development and health of students have been generalized. Functions of educational environment: adaptive, formative, educational have been discovered. The approaches to education environment monitoring: expertise and diagnostics have been described. The results of empirical study of the ecology of the university educational environment, conducted via questionnaires have been presented. The study revealed the risks of the educational environment of the university, as well as its comfort degree. Ecopsychological models (segments) which conceptualizes the relationship of the subjects of education and educational environment: health-saving environment, tolerant environment, psychologically safe environment, safe information-virtual environment, constructive communicative (verbal) space, creative environment, ecological environment have been described. The eco-psychological designing of educational environment will allow to minimize social risk factors, negative psychophysical impact and provide students with adequate conditions for development, safety, identity, self-actualization. © 2017, Kislyakov P. A.

Chistiakov D.A.,Moscow State University | Chekhonin V.P.,Russian State Social University
European Journal of Pharmacology | Year: 2012

Glioblastomas, particularly high grade brain tumors such as glioblastoma multiforme, are characterized by increased anaplasy, malignancy, proliferation, and invasion. These tumors exhibit high resistance to radiation therapy and treatment with anti-cancer drugs. The radio- and chemoresistance of gliomas is attributed to cancer stem cells (CSCs) that are considered as major contributors for maintenance and propagation of tumor cell mass, cancer malignancy and invasiveness, and tumor cell survival after courses of radiotherapy and medical interventions. MicroRNAs (miRNAs), key post-transcriptional gene regulators, have altered expression profiles in gliomas. Some of miRNAs whose expression is markedly up-regulated in brain tumors are likely to have a pro-oncogenic role through supporting growth, proliferation, migration, and survival of cancer stem and non-stem cells. In contrast, a population of miRNA possessing anti-tumor effects is suppressed in gliomas. In this review, we will consider miRNAs and their influence on radio- and chemoresistance of gliomas. These miRNAs harbor a great therapeutic significance as potent agents in future targeted anti-cancer therapy to sensitize glioma tumor cells and CSCs to cytotoxic effects of radiation exposure and treatment with anti-cancer drugs. © 2012 Elsevier B.V. All rights reserved.

Yu Z.S.,Russian State Social University
Annual Research and Review in Biology | Year: 2017

Newborn calves still often suffer from iron deficiency. This state damages their growth and development - to some extent, due to the development of pathological changes in hemostasis. Thereby, both veterinary science and cattle physiology give great scientific and practical significance to the search of approaches to effective correction of new-born calves’ hemostasis pathology connected with iron deficiency. It seemed to be perspective to evaluate the influence degree of ferroglukin, traditionally applied at iron deficiency, in combination with metabolism stimulators (fosprenil and hamavit) on new-born calves’ indices of hemostasis system. During our study it was established that new-born calves with iron deficiency were also characterized by decreased plasma antioxidant protect-ability, intensity of lipids’ peroxidation processes, increase of platelets’ hemostatic activity and blood coagulation system along with the decrease of vascular wall’s ability to bind it. In our study we found that combination of ferroglukin, fosprenil and hamavit given to newborn calves with iron deficiency showed improved plasma antioxidant and lipid peroxidation activity. Normalization of platelet activity, positive dynamics of hemostasis vascular and plasma components were also observed. Iron deficiency of new-born calves can be considered as the model of hemostasis abnormality. With its help we could try different means and their combinations to cure the pathology of hemostasis. The obtained results allowed us to consider the usage of fosprenil and hamavit combination on the background of ferroglukin to be sufficient for reducing the pathology of hemostasis in newborn calves with iron deficiency. © 2017 Yu.

Medvedev I.N.,Russian State Social University
Annual Research and Review in Biology | Year: 2017

Platelets, as one of the main elements of a body’s homeostasis, support it on the whole and especially blood system. Through the modulation of their activity in response to different impacts they can influence the microcirculation and the level of tissue metabolism. The aim of our research is to determine platelet aggregative activity of healthy people of the first mature age which have long regular physical training in the section of hand-to-hand fighting. We took 112 healthy people of the first mature age, who had trained since childhood in hand-to-hand fighting section, into our experimental group. The control group was composed of 97 healthy people of the first mature age who had avoided any exercises during their lifetime. We applied biochemical, hematological and statistical methods of investigation. Physically trained people during the first mature age had stable low lipids’ peroxidation in platelets. This experimental group also had stable low platelet aggregation. The constancy of platelet aggregative response to strong and weak inductors of handto- hand fighters was provided by stable low activity of platelet receptors and intraplatelet mechanisms of their aggregation. Basing on the mentioned information, we could state that regular physical training in hand-to-hand fighting section since childhood provided the fighters of the first mature age with stable low platelet activity. It also helped to create better conditions for microcirculation and hemostasis. In people, who had avoided exercises, there was increase of platelet aggregation at the first mature age though they could have no complaints on their health. © 2017 Medvedev.

Glagoleva T.I.,All Russian Research Institute of Physiology | Zavalishina S.Y.,Russian State Social University
Annual Research and Review in Biology | Year: 2017

Estimation of ontogenetic peculiarities of aggregation of regular blood elements and vascular control over it, including calves in the middle of early ontogenesis-in the phase of milk-vegetable nutrition, is of great scientific and practical interest. Clarification of their physiological balance is really significant for receiving the possibility of regulation of hemostasis activity and metabolism intensity in tissues. To estimate aggregative activity of regular blood elements and disaggregating vessels’ control over them in calves during the phase of milk vegetable nutrition. We formed a group of calves of black-many-colored breed which were examined 5 times at the age between the 31st and the 90th days of life with the application of biochemical, hematological and statistical methods of investigation. Farm “Kolos” of Fatezh district, Kursk region, Russia, spring 2014. The work was conducted with the help of 41 calves of black many-colored breed taken into investigation on the 31st day of life. Examination was conducted on the 31st, 45th, 60th, 75th and 90th days of calves’ lives. We estimated the intensity of lipids’ peroxidation in plasma, aggregation of erythrocytes, platelets and neutrophils in plasma received without application of a cuff on a vessel and with its usage. The calves of 45 days of life were noted to have short-period increase of summary erythrocytes’ quantity in aggregate (on 15.9%) and aggregates’ quantity (on 13.4%) at decrease of free erythrocytes (on 9.7%). Given indices returned in calves to the initial level by the 90th day of life. In plasma after temporary venous occlusion in calves by the 45th day of life summary erythrocytes’ quantity in aggregates (on 21.7%) and aggregates’ number (on 16.3%) had a shortterm increase at decrease of free erythrocytes on 13.9%. By the 45th day of life their time of platelets’ aggregation development with collagen shortened to 22.5±0.12s returning by the end of investigation to the initial level. In plasma after temporary venous occlusion we found peak acceleration of platelets’ aggregation by the 45th day of life. The calves of 45days of life were noted to have strengthening of neutrophils’ aggregation with lectin on 10.1%, concanavalin A-on 9,4%, phytohemagglutinin-on 19.1% eliminated by the 90th day of life. Found in calves of 45 days of life short-period strengthening of formular blood elements’ aggregation was combined with brief weakening of their deaggregating vascular activity. © 2017 Glagoleva and Zavalishina.

Yu Z.S.,Russian State Social University
Annual Research and Review in Biology | Year: 2017

In modern biology we still have the actual demand of further investigation of aging aspects of mammals and human beings. Great attention in this investigation is devoted to different aspects of blood rheological peculiarities and its regular elements, i.e. in aging aspect, in normal state and in some pathology conditions and, also, on the background of many variants of correctional impacts on an organism. The purpose is to establish the age dynamics of microrheological particular properties of aging rats’ red blood cells. The study involved 95 healthy Wistar male rats that included 32 rats of 18 months of age, 29 rats of 24 months and 34 rats of 30 months of age. We used biochemical, hematological and statistical methods. The control group was represented by 27 healthy Wistar male rats. Examined animals on the background of aging were noted to have activity increase of freely radical lipids’ oxidation in the liquid part of blood at the decrease of AOA from 30.70±0.32% at 18 months to 24.40±0.29% at 30 months. Analogical values in the control group were 1.440±0.007 D233/1 ml, 3.460±0.016 umol/l and 34.8±0.010%, correspondingly. Similar picture of POL dynamics of examined animals was also found in erythrocytes: Levels of AHP and MDA in them gradually increased – from 18 months of life to 30 months of life on 27.2% and 26.1%, correspondingly. At the same time experimental rats between 18 and 30 months of life were noted to have increase of erythrocytes’ aggregation activity with the rise of their summary inclusion into aggregates and quantity of aggregates at the lowering of free erythrocytes’ number (228.70±0.31), in comparison with control rats. Found increase of their aggregation is mostly provided by appearing changes in the charge of erythrocyte membranes due to degradation of some negatively charged glycoproteins on them under the influence of increasing with age lipid peroxidation. Aggregation also increases due to inhibition of adenylate cyclase in erythrocytes what leads to the amount decrease of cyclical adenosine phosphate in them and to the stimulation of Ca2+ inflow into them. Development of oxidative damage in plasma globular protein “bridges” between erythrocytes, providing their aggregation, increases erythrocytes’ disaggregation threshold due to the increase of their connection in aggregates. Age increasing erythrocytes’ aggregation in rats negatively influences microcirculation and contributes significantly to marked with aging morbid aggravation due to strengthening a body’s sensitivity to negative impacts of environmental factors which promote the realization of hereditary predisposition to various diseases. © 2017 Yu.

Chistiakov D.A.,Moscow State University | Chekhonin V.P.,Russian State Social University
Journal of Applied Genetics | Year: 2012

Human aggression/impulsivity-related traits have a complex background that is greatly influenced by genetic and non-genetic factors. The relationship between aggression and anxiety is regulated by highly conserved brain regions including amygdala, which controls neural circuits triggering defensive, aggressive, or avoidant behavioral models. The dysfunction of neural circuits responsible for emotional control was shown to represent an etiological factor of violent behavior. In addition to the amygdala, these circuits also involve the anterior cingulated cortex and regions of the prefrontal cortex. Excessive reactivity in the amygdala coupled with inadequate prefrontal regulation serves to increase the likelihood of aggressive behavior. Developmental alterations in prefrontal-subcortical circuitry as well as neuromodulatory and hormonal abnormality appear to play a role. Imbalance in testosterone/serotonin and testosterone/cortisol ratios (e. g., increased testosterone levels and reduced cortisol levels) increases the propensity toward aggression because of reduced activation of the neural circuitry of impulse control and self-regulation. Serotonin facilitates prefrontal inhibition, and thus insufficient serotonergic activity can enhance aggression. Genetic predisposition to aggression appears to be deeply affected by the polymorphic genetic variants of the serotoninergic system that influences serotonin levels in the central and peripheral nervous system, biological effects of this hormone, and rate of serotonin production, synaptic release and degradation. Among these variants, functional polymorphisms in the monoamine oxidase A (MAOA) and serotonin transporter (5-HTT) may be of particular importance due to the relationship between these polymorphic variants and anatomical changes in the limbic system of aggressive people. Furthermore, functional variants of MAOA and 5-HTT are capable of mediating the influence of environmental factors on aggression-related traits. In this review, we consider genetic determinants of human aggression, with special emphasis on genes involved in serotonin and dopamine metabolism and function. © 2011 Institute of Plant Genetics, Polish Academy of Sciences, Poznan.

Shcherbakova A.I.,Russian State Social University
Life Science Journal | Year: 2014

The article tells about the philosophical analysis of music as artistic and aesthetic phenomenon that reveals difficult questions of life to the comprehending person. Music education is regarded as a tool to promote the penetration in the music space. This work investigates the music complexity and diversity as an art form, many approaches are presented that help the person to freely navigate the world of music. The author focuses on the problem of the interaction of music and music education as the two inextricably linked systems, their harmonious unity is a source of constant development and improvement of musical space, as well as artistic and aesthetic space of culture in general.

Chistiakov D.A.,Moscow State University | Chekhonin V.P.,Russian State Social University
Tumor Biology | Year: 2014

Extracellular vesicles (EVs) are commonly used by normal and tumor cells for communication at long distances to exchange by complex molecular messages and deliver a variety of essential biomolecules. EVs (exosomes and microvesicles) released in large numbers by glioma cells represent a key mechanism of intercellular signaling. Tumor-derived EVs are produced to regulate all vital functions of tumor cells including growth, proliferation, migration, survival, malignancy, invasion, and resistance to host anti-tumor immunity and anti-cancer drugs. Glioma EVs were shown to carry a variety of biomolecules such as oncogenic growth factors, receptors, enzymes, transcription factors, signaling and immunomodulatory molecules, DNA of mutated and nonmutated oncogenes, RNA transcripts, and noncoding RNA including retrotransposons, vault RNA, and microRNAs. Glioma-derived EVs can be useful as a source of potential tumor-associated biomarkers essential for development and validation of new diagnostic and prognostic tools for glioma and glioblastoma. Tumor EVs are enriched with glioma antigens that could be helpful, for example, for development of new advanced anti-tumor immune vaccines based on autologous dendritic cells stimulated by tumor-specific antigens. © 2014, International Society of Oncology and BioMarkers (ISOBM).

Sokolenko E.V.,Russian State Social University
Inorganic Materials | Year: 2014

IR absorption spectra of diamond nanoclusters are calculated by a semiempirical method (with PM3 parameterization), and the effects of cluster size, impurities, and native defects on the position and strength of absorption bands are examined. © 2014 Pleiades Publishing, Ltd.

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