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Rugal V.I.,Russian Research Institute of Hematology and Transfusion of FMBA | Semenova N.Yu.,Russian Research Institute of Hematology and Transfusion of FMBA | Voloshin S.V.,Russian Research Institute of Hematology and Transfusion of FMBA | Bessmeltsev S.S.,Russian Research Institute of Hematology and Transfusion of FMBA
Genes and Cells | Year: 2014

We studed nicheforming structures in trephine biopsies and lymph node biopsies patients with CLL using histological and immunohistochemistry methods. Changes of stromal nicheforming structures indicate of their involvement in the genesis of neoplastic transformation of lymphoid precursors and can identify the realignment of the microenvironment function directed on maintenance of leukemic clone.

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