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Karpov Y.A.,Russian Cardiology Research Complex
Terapevticheskii Arkhiv | Year: 2012

This review provides an analysis of the results of Russian and foreign clinical trials that have shown a high antihypertensive efficacy and tolerability of combined medications containing fixed doses of perindopril and indapamide.

Fedorovich A.A.,Russian Cardiology Research Complex
Microvascular Research | Year: 2012

Correlation between metabolic and microhemodynamic processes in skin was assessed through acute pharmacological test with metabolically active Actovegin in 28 healthy volunteers. Laser Doppler flowmetry in combination with wavelet analysis of blood flow oscillations was used to identify functional state of arteriolar-venular areas of microvascular bed in the right forearm skin; capillary blood flow parameters were assessed through computer capillaroscopy in the nail bed of the right hand on the 4th finger. The metabolic effect (improved oxygen uptake and glucose disposal by tissues) was accompanied by significant increase in endothelial rhythm amplitude by 98% (p. <. 0.00006), neurogenic rhythm amplitude by 50% (p. <. 0.003) and myogenic rhythm amplitude by 54% (p. <. 0.03), with capillary blood flow rate increasing by 90. μm/s (p. <. 0.04), pericapillary zone reducing by 15. μm (p. <. 0.0001) and diastolic blood pressure dropping by 4. mm Hg (p. <. 0.02). These results show close correlation between metabolic and microhemodynamic processes, which suggests that the amplitude activity within the range of endothelial rhythm (0.0095-0.021. Hz) during laser Doppler flowmetry reflects not only solely vasomotor function but also metabolic function of microvascular endothelium. © 2012 Elsevier Inc.

Boytcov S.A.,State Research Center for Preventive Medicine | Urazalina S.J.,Russian Cardiology Research Complex | Kukharchuk V.V.,Cardiology Research Complex | Balakhonova T.V.,Cardiology Research Complex | Sergienko I.V.,Cardiology Research Complex
Acta Cardiologica | Year: 2015

Aim The aim of this paper is to study the degree of subclinical arterial wall damage in subjects at low and moderate risk of cardiovascular death by the SCORE scale using instrumental research methods. Methods We enrolled 600 patients (mean age 49.0 ± 7.1 years, 74% women) with a calculated SCORE ≤ 5%, who passed a carotid duplex ultrasonography with a measurement of the intima-media thickness (IMT) and carotid plaque (CP) severity. In the study a computer sphygmography was also performed on the subjects to determine ankle-brachial pulse wave velocity (abPWV) and an ankle-brachial index (ABI). Results We found 389 (64%) patients with subclinical signs of atherosclerosis. CPs were found in 359 patients (60%), thickened IMT in 28 patients (5%), increased abPWV in 227 patients (38%), and ABI of < 0.9 in 29 patients (5%). In the patients with a thickened IMT only two had no CPs. In contrast, 92% of the patients with CPs had normal IMT. Increased abPWV was determined in 87% participants with CPs, and only in 30 subjects no CPs were found. All 29 patients with an ABI of less than 0.9 had CPs. The “presence of CP” was the most sensitive parameter in the patients included in the study, in terms of atherosclerosis determination (92%). The identification of individuals with CPs significantly increased in men over 45 years of age (in 68.4% of cases, P = 0.009), and in women over 50 (in 61.8% of cases, P = 0.001). Conclusion Our data reinforces the importance of non-invasive imaging of atherosclerosis in subjects at low and moderate cardiovascular risk. The study demonstrated a high prevalence of subclinical atherosclerosis signs in patients at low to moderate risk by the SCORE scale and a high detection frequency of carotid plaques. This suggests that wider implementation of carotid ultrasound in primary care algorithms may improve risk stratification with timely initiation of preventive strategies. © Acta Cardiologica. All rights reserved.

Lankin V.Z.,Russian Cardiology Research Complex | Konovalova G.G.,Russian Cardiology Research Complex | Tikhaze A.K.,Russian Cardiology Research Complex | Shumaev K.B.,Russian Cardiology Research Complex | And 3 more authors.
Journal of Diabetes | Year: 2016

Background: The aim of the present study was to examine the effect of aldehyde modification on antioxidant enzyme activity in diabetic patients. Methods: The activity of commercially available antioxidant enzymes (catalase, glutathione peroxidase [GPx], and Cu,Zn-superoxide dismutase [SOD]) was determined in vitro prior to and after aldehyde modification. The activity of erythrocyte Cu,Zn-SOD was assayed in blood drawn from healthy donors, diabetic patients with decompensated carbohydrate metabolism, and diabetic patients after glucose-lowering therapy. Results: In vitro aldehyde modification had no effect on catalase activity, but diminished GPx and Cu,Zn-SOD activity. In diabetic patients with decompensated carbohydrate metabolism, glucose-lowering therapy significantly increased Cu,Zn-SOD activity, the effect being especially pronounced after administration of metformin. Conclusions: It is likely that metformin antagonizes the aldehyde-induced inhibition of erythrocyte Cu,Zn-SOD in diabetic patients more effectively than sulfonylurea drugs. © 2016 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.

Lankin V.Z.,Russian Cardiology Research Complex | Tikhaze A.K.,Russian Cardiology Research Complex | Kumskova E.M.,Russian Cardiology Research Complex
Molecular and Cellular Biochemistry | Year: 2012

In this study, we show that low density lipoproteins (LDL) from human blood plasma which was oxidized by animal C-15 lipoxygenase is taken up by cultivated human macrophages with the same effectiveness as with non-oxidized (native) LDL. At the same time malonyldialdehyde-modified LDL is captured by cultivated macrophages very actively. Based on differences in catabolism of LDL with various levels of primary and secondary products of free-radical oxidation, it was offered to discriminate between the oxidized LDL itself (lipohydroperoxide- rich LDL) and the LDL that was chemically modified by free-radical oxidation secondary products of aldehyde nature. In this respect, aldehyde-modified but not oxidized (lipohydroperoxide-containing) LDL is atherogenic. © 2012 Springer Science+Business Media, LLC.

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