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Maksimenko A.V.,Russian Cardiology Research and Production Complex
Russian Journal of General Chemistry | Year: 2014

The present review considers therapeutic protein conjugates (bioconjugates) in terms of the concept of drug targeting delivery in the body. © 2014 Pleiades Publishing, Ltd.

In the Russian program FORTISSIMO administration of fixed combination of perindopril arginine/indapamide (10 mg/2.5 mg) in 2120 patients with poorly controlled arterial hypertension instead of angiotensin converting enzyme inhibitors (ACEI) or β-receptor antagonists (ARB) with hydrochlorothiazide given separately or in fixed combinations resulted in significant lowering of arterial pressure (AP) and achievement of its target level in 84% of patients. Mean AP was lowered from 177/99 to 130/80 mm Hg in 3 months while substantial reduction down to 149/89 mm Hg occurred just after 2 weeks of treatment. Improvement of compliance to therapy was also noted. Fixed perindopril/ indapamide combination was well tolerated and turned out to be effective for AP control irrespective of previously conducted therapy (ACEI or ARB with diuretic).

Omboni S.,Italian Institute of Telemedicine | Posokhov I.N.,Hemodynamic Laboratory | Rogoza A.N.,Russian Cardiology Research and Production Complex
International Journal of Hypertension | Year: 2015

Objective. Central blood pressure (BP) and vascular indices estimated noninvasively over the 24 hours were compared between normotensive volunteers and hypertensive patients by a pulse wave analysis of ambulatory blood pressure recordings. Methods. Digitalized waveforms obtained during each brachial oscillometric BP measurement were stored in the device memory and analyzed by the validated Vasotens technology. Averages for the 24 hours and for the awake and asleep subperiods were computed. Results. 142 normotensives and 661 hypertensives were evaluated. 24-hour central BP, pulse wave velocity (PWV), and augmentation index (AI) were significantly higher in the hypertensive group than in the normotensive group (119.3 versus 105.6 mmHg for systolic BP, 75.6 versus 72.3 mmHg for diastolic BP, 10.3 versus 10.0 m/sec for aortic PWV,-9.7 versus-40.7% for peripheral AI, and 24.7 versus 11.0% for aortic AI), whereas reflected wave transit time (RWTT) was significantly lower in hypertensive patients (126.6 versus 139.0 ms). After adjusting for confounding factors a statistically significant between-group difference was still observed for central BP, RWTT, and peripheral AI. All estimates displayed a typical circadian rhythm. Conclusions. Noninvasive assessment of 24-hour arterial stiffness and central hemodynamics in daily life dynamic conditions may help in assessing the arterial function impairment in hypertensive patients. © 2015 Stefano Omboni et al.

Kropacheva E.S.,Russian Cardiology Research and Production Complex
Kardiologiya | Year: 2014

The article deals with renal dysfunction, methods of assessment and monitoring in patients receiving anticoagulant therapy. Due to the negative impact of renal impairment on the incidence of thromboembolic and hemorrhagic complications in patients with atrial fibrillation problem identifying renal failure and its degree is an actual problem. Set forth in Article current recommendations and practical aspects of the evaluation of renal function and selecting dosing regimen can improve the safety of anticoagulants therapy.

Chistiakov D.A.,Moscow State University | Sobenin I.A.,Russian Cardiology Research and Production Complex | Orekhov A.N.,Russian Academy of Medical Sciences | Bobryshev Y.V.,University of New South Wales
Current Pharmaceutical Design | Year: 2014

Medial artery calcification (MAC) is a characteristic feature of diabetes. MAC represents a concentric calcification that proceeds via matrix vesicle-nucleated mineralization accompanied with apatitic calcium phosphate deposits in the arterial tunica media in the absence of atheroma and neointima. Multiple factors contribute to the induction and progression of diabetic MAC including inflammation, oxidative stress, adiposity, insulin resistance, advanced glycation end-products, and hyperphosphatemia. Osteoblast-like cells form in the vessel wall from vascular smooth muscle cells and multipotent vascular mesenchymal progenitors. These mineralizing cells as well as the recruitment of undifferentiated progenitors to the osteochondrocyte lineage play a critical role in the calcification process. Important transcription factors such as Msx 2, Osterix, and RUNX2 are crucial in the programming of osteogenesis. Currently, no therapy is available to reverse vascular calcification. Available therapies can only reduce and slow the progression of vascular calcification. Targeting regulatory proteins and enzymes directly involved in osteochondrogenesis and hydroxyapatite accumulation in the vascular wall may be beneficial for generating new efficient anti-calcific drugs. © 2014 Bentham Science Publishers.

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