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Rotov K.A.,Russian Agency for Health and Consumer Rights | Tikhonov S.N.,Russian Agency for Health and Consumer Rights | Alekseev V.V.,Russian Agency for Health and Consumer Rights | Snatenkov E.A.,Russian Agency for Health and Consumer Rights
Bulletin of Experimental Biology and Medicine | Year: 2012

We present data on pharmacokinetics of free and liposomal forms of gentamicin. Comparative study of two drug forms showed that immobilization of gentamicin in liposomes significantly increased most important pharmacokinetic parameters of the antibiotic (AUC, Cmax, MRTpo, T1/2, Kel, Vzpo) and reduced Clpo and Kel. © 2012 Springer Science+Business Media, Inc. Source


Tikhonov S.N.,Russian Agency for Health and Consumer Rights | Rotov K.A.,Russian Agency for Health and Consumer Rights | Alekseev V.V.,Russian Agency for Health and Consumer Rights | Snatenkov E.A.,Russian Agency for Health and Consumer Rights | Khrapova N.P.,Russian Agency for Health and Consumer Rights
Bulletin of Experimental Biology and Medicine | Year: 2010

A new method for obtaining the liposomal formulation of streptomycin and tetracycline is described in the present work. The physicochemical properties of this formulation were evaluated. We compared the effects of free and liposomal formulations from streptomycin and tetracycline on activity of liver enzymes in albino mice. Immobilization of antibiotics in liposomes was followed by a decrease in the inhibitory effect on protease, alkaline phosphatase, and phosphorylase. The infl uence of this preparation on ATPase was reduced by 2 times. © 2010 Springer Science+Business Media, Inc. Source

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