Russian Academy of Sciences, DuPont Company, Ovchinnikov, Bobkova, Medvinskaya, Samokhin and Nekrasov | Date: 2017-04-19
The present invention relates to the field of genetic engineering and medicine. Proposed is a method for treating neurodegenerative diseases and Alzheimers disease that includes the intranasal administration to a subject of a therapeutically effective amount of the YB-1 protein and/or active fragment and/or derivative thereof.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: BG-10-2016 | Award Amount: 8.10M | Year: 2016
Blue-Action will provide fundamental and empirically-grounded, executable science that quantifies and explains the role of a changing Arctic in increasing predictive capability of weather and climate of the Northern Hemisphere.To achieve this Blue-Action will take a transdisciplinary approach, bridging scientific understanding within Arctic climate, weather and risk management research, with key stakeholder knowledge of the impacts of climatic weather extremes and hazardous events; leading to the co-design of better services.This bridge will build on innovative statistical and dynamical approaches to predict weather and climate extremes. In dialogue with users, Blue-Arctic will take stock in existing knowledge about cross-sectoral impacts and vulnerabilities with respect to the occurrence of these events when associated to weather and climate predictions. Modeling and prediction capabilities will be enhanced by targeting firstly, lower latitude oceanic and atmospheric drivers of regional Arctic changes and secondly, Arctic impacts on Northern Hemisphere climate and weather extremes. Coordinated multi-model experiments will be key to test new higher resolution model configurations, innovative methods to reduce forecast error, and advanced methods to improve uptake of new Earth observations assets are planned. Blue-Action thereby demonstrates how such an uptake may assist in creating better optimized observation system for various modelling applications. The improved robust and reliable forecasting can help meteorological and climate services to better deliver tailored predictions and advice, including sub-seasonal to seasonal time scales, will take Arctic climate prediction beyond seasons and to teleconnections over the Northern Hemisphere. Blue-Action will through its concerted efforts therefore contribute to the improvement of climate models to represent Arctic warming realistically and address its impact on regional and global atmospheric and oceanic circulation.
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: INFRASUPP-6-2014 | Award Amount: 1.70M | Year: 2015
This CREMLIN proposal is to foster scientific cooperation between the Russian Federation and the European Union in the development and scientific exploitation of large-scale research infrastructures. It has been triggered by the recent so-called megascience projects initiative launched by and in the Russian Federation which is now very actively seeking European integration. The proposed megascience facilities have an enormous potential for the international scientific communities and represent a unique opportunity for the EU to engage in a strong collaborative framework with the Russian Federation. The CREMLIN proposal is a first and path finding step to identify, build and enhance scientific cooperation and strong enduring networks between European research infrastructures and the corresponding megascience facilities to maximize scientific returns. The proposal follows the specific recommendations of an EC Expert Group by devising concrete coordination and support measures for each megascience facility and by developing common best practice and policies on internationalisation and opening. CREMLIN will thus effectively contribute to better connect Russian RIs to the European Research Area.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-07b-2015 | Award Amount: 7.99M | Year: 2016
The goal of GenTree is to provide the European forestry sector with better knowledge, methods and tools for optimising the management and sustainable use of forest genetic resources (FGR) in Europe in the context of climate change and continuously evolving demands for forest products and services. To reach its goal, GenTree will make scientific, technological and implementation breakthroughs in: (i) designing innovative strategies for dynamic conservation of FGR in European forests, (ii) broadening the range of FGR used by European breeding programmes, and (iii) preparing new forest management scenarios and policy frameworks fully integrating genetic conservation and breeding aspects, to adapt forests and forestry to changing environmental conditions and societal demands. GenTree focuses on economically and ecologically important tree species in Europe, growing in a wide range of habitats and covering different societal uses and values. The major outputs of GenTree will include: (i) much needed new scientific knowledge on phenotypic and genotypic diversity across environmental gradients in Europe, (ii) improved genotyping and phenotyping monitoring tools for practitioners, (iii) updated and refined data for information systems of in-situ and ex-situ FGR collections, (iv) innovative strategies for conservation, breeding and exchanging and using diversified forest reproductive material, (v) novel outreach and science-policy support tools to better integrate FGR concerns into forest management and better implement relevant international commitments in Europe. GenTree will improve the status and use of European in-situ and ex-situ FGR collections, support acquisition, conservation, characterisation, evaluation and use of relevant FGR in breeding and forestry practice and policy, will seek to harmonise, rationalise and improve management of existing collections and databases, and will strengthen the EU strategy for cooperation on FGR research and innovation.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: NFRP-12-2015 | Award Amount: 3.05M | Year: 2015
HoNESt (History of Nuclear Energy and Society) involves an interdisciplinary team with many experienced researchers and 24 high profile research institutions. HoNESts goal is to conduct a three-year interdisciplinary analysis of the experience of nuclear developments and its relationship to contemporary society with the aim of improving the understanding of the dynamics over the last 60 years. HoNESts results will assist the current debate on future energy sources and the transition to affordable, secure, and clean energy production. Civil societys interaction with nuclear developments changes over time, and it is locally, nationally and transnationally specific. HoNESt will embrace the complexity of political, technological and economic challenges; safety; risk perception and communication, public engagement, media framing, social movements, etc. Research on these interactions has thus far been mostly fragmented. We will develop a pioneering integrated interdisciplinary approach, which is conceptually informed by Large Technological Systems (LTS) and Integrated Socio-technical System (IST), based on a close and innovative collaboration of historians and social scientists in this field. HoNESt will first collect extensive historical data from over 20 countries. These data will be jointly analyzed by historians and social scientists, through the lens of an innovative integrated approach, in order to improve our understanding of the mechanisms underlying decision making and associated citizen engagement with nuclear power. Through an innovative application of backcasting techniques, HoNESt will bring novel content to the debate on nuclear sustainable engagement futures. Looking backwards to the present, HoNESt will strategize and plan how these suitable engagement futures could be achieved. HoNESt will engage key stakeholders from industry, policy makers and civil society in a structured dialogue to insert the results into the public debate on nuclear energy.
Dykman L.A.,Russian Academy of Sciences |
Khlebtsov N.G.,Russian Academy of Sciences
Chemical Reviews | Year: 2014
Recent progress in understanding how size, shape, and surface properties of gold nanoparticles (GNPs) affect their uptake and intracellular fate is studied. The selective penetration of GNPs into cancer and immune cells and the interaction of GNPs with immune cell receptors is also studied. The cellular uptake of spherical GNPs is a receptor-mediated process, the effectiveness of which depends on the size of particles and on the density of ligand coating. Most experimental data accrued for colloidal gold particles confirm the existence of an optimal diameter range, whereas the specific optimal size for uptake may depend on cell type. With an increase in the particle aspect ratio, the effectiveness of GNP uptake into cells decreases; the exocytosis time may also decrease. GNP uptake into cells of the immune system activates the production of pro-inflammatory cytokines, a finding that indicates directly that GNPs are immunostimulatory.
Khlebtsov N.,Chernyshevsky Saratov State University |
Dykman L.,Russian Academy of Sciences
Chemical Society Reviews | Year: 2011
Recent advances in wet chemical synthesis and biomolecular functionalization of gold nanoparticles have led to a dramatic expansion of their potential biomedical applications, including biosensorics, bioimaging, photothermal therapy, and targeted drug delivery. As the range of gold nanoparticle types and their applications continues to increase, human safety concerns are gaining attention, which makes it necessary to better understand the potential toxicity hazards of these novel materials. Whereas about 80 reports on the in vivo biodistribution and in vitro cell toxicity of gold nanoparticles are available in the literature, there is lack of correlation between both fields and there is no clear understanding of intrinsic nanoparticle effects. At present, the major obstacle is the significant discrepancy in experimental conditions under which biodistribution and toxicity effects have been evaluated. This critical review presents a detailed analysis of data on the in vitro and in vivo biodistribution and toxicity of most popular gold nanoparticles, including atomic clusters and colloidal particles of diameters from 1 to 200 nm, gold nanoshells, nanorods, and nanowires. Emphasis is placed on the systematization of data over particle types and parameters, particle surface functionalization, animal and cell models, organs examined, doses applied, the type of particle administration and the time of examination, assays for evaluating gold particle toxicity, and methods for determining the gold concentration in organs and distribution of particles over cells. On the basis of a critical analysis of data, we arrive at some general conclusions on key nanoparticle parameters, methods of particle surface modification, and doses administered that determine the type and kinetics of biodistribution and toxicity at cellular and organismal levels (197 references). © 2011 The Royal Society of Chemistry.
Kartashov Y.V.,Russian Academy of Sciences
Optics Letters | Year: 2013
I study vector solitons involving two incoherently coupled field components in periodic parity-time (PT)-symmetric optical lattices. The specific symmetry of the lattice imposes restrictions on the symmetry of available vector soliton states. While all configurations with asymmetric intensity distributions are prohibited, such lattices support multihump solitons with an equal number of "in-phase" or "out-of-phase" spots in two components, residing on neighboring lattice channels. In the focusing medium, only the solitons containing out-of-phase spots in at least one component can be stable, while in the defocusing medium stability is achieved for structures consisting of in-phase spots. Mixed-gap vector solitons with components emerging from different gaps in the lattice spectrum also exist and can be stable in the PT-symmetric lattice. © 2013 Optical Society of America.
Trifonov A.A.,Russian Academy of Sciences
Coordination Chemistry Reviews | Year: 2010
The review summarizes advances in the chemistry of organo rare-earth complexes containing bulky guanidinate and amidopyridinate ligands. The methods of synthesis, structures, reactivities and catalytic activities of various types of alkyl and hydrido complexes and their precursors are considered. © 2010 Elsevier B.V. All rights reserved.
Dykman L.,Russian Academy of Sciences |
Khlebtsov N.,Chernyshevsky Saratov State University
Chemical Society Reviews | Year: 2012
Gold nanoparticles (GNPs) with controlled geometrical, optical, and surface chemical properties are the subject of intensive studies and applications in biology and medicine. To date, the ever increasing diversity of published examples has included genomics and biosensorics, immunoassays and clinical chemistry, photothermolysis of cancer cells and tumors, targeted delivery of drugs and antigens, and optical bioimaging of cells and tissues with state-of-the-art nanophotonic detection systems. This critical review is focused on the application of GNP conjugates to biomedical diagnostics and analytics, photothermal and photodynamic therapies, and delivery of target molecules. Distinct from other published reviews, we present a summary of the immunological properties of GNPs. For each of the above topics, the basic principles, recent advances, and current challenges are discussed. © The Royal Society of Chemistry 2012.