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Haifa, Israel

The Russell Berrie Nanotechnology Institute was established in January 2005 as a joint endeavour of the Russell Berrie Foundation, the government of Israel and the Technion, Israel Institute of Technology. It is one of the largest academic programs in Israel and is among the largest nanotechnology centers in Europe and the US.Prof. Yeshayahu Talmon of the Technion Faculty of Chemical Engineering is the Director of RBNI since 2010, when he took over from Prof. Uri Sivan. RBNI has over 110 faculty members and approximately 300 graduate students and postdoctoral fellows under its auspices at Technion. Its multidisciplinary activities span 14 different faculties. Wikipedia.

Lifshitz E.,Russell Berrie Nanotechnology Institute
Journal of Physical Chemistry Letters | Year: 2015

The Perspective focuses on the investigation of an unresolved conflict in semiconductor colloidal quantum dots (CQDs) research, concerning the influence of the immediate surrounding on the optical properties of the materials. Today's advanced synthetic colloidal procedures offer formation of a high-quality inorganic crystallite, capped with various organic/inorganic molecular ligands. The Perspective aims to clarify whether exciton recombination processes in CQDs are influenced by the type of crystallite-ligand bonding and, moreover, whether these excitonic processes experience direct coupling to the ligands' vibrational modes. Most ligands used have redox characteristics whose functional groups are added on to the CQDs' surface via coordination, covalent or ionic bonding. The surface-ligand bonding introduces electronic states either above or below the intraband/interband energy gap, resulting in electronic passivation or in creation of trapping states that affect intraband and interband relaxation processes. Furthermore, crystalline electronic states may have a direct coupling to molecular vibrational states via direct overlap of electronic wave functions or through a long-range energy-transfer process. Also, photoejected carriers resulting from an Auger process or ionization processes may diffuse temporarily onto a ligand site. These scenarios are discussed in the current publication with supporting theoretical and experimental observations. © 2015 American Chemical Society. Source

Tisch U.,Technion - Israel Institute of Technology | Haick H.,Russell Berrie Nanotechnology Institute
MRS Bulletin | Year: 2010

Arrays of cross-reactive sensors for the detection of multi-component chemical and biological agents have been actively developed during the past two decades. The rapid progress in this field has been driven by the need for fast online detection of a wide range of chemical and biological compounds and mixtures in different branches of Industry and in medicine. Nanomaterials are ideal base materials for such sensor arrays because they are chemically versatile, can easily be fabricated, and can be integrated Into existing sensing platforms to increase the sensitivity to the target agents. We present a concise though non-exhaustive didactic review of the main concepts and approaches related to the use of nanomaterials in cross-reactive sensor arrays. We focus on electronic transducers Incorporating the most important classes of nanomaterials: molecularly modified metal nanoparticles, metal oxide nanoparticles, carbon nanotubes, and semiconducting nanowires. Selected examples of their integration into sensors and sensor arrays are given. We conclude with a brief discussion of the possibilities that the Integration of the different types of nanomaterials into sensor arrays offer and the expected limitations. Source

Paz Y.,Russell Berrie Nanotechnology Institute
Applied Catalysis B: Environmental | Year: 2010

A review of patents on the application of titanium dioxide photocatalysis for air treatment is presented. A comparison between water treatment and air treatment reveals that the number of scientific publications dedicated to photocatalytic air treatment is significantly lower than the number of scientific manuscripts dedicated to photocatalytic water treatment, yet the situation is reversed upon comparing relevant patents. This indicates a growing interest in the implementation of photocatalysis for air treatment purposes, which surpasses that of water treatment. This manuscript analyzes the various patents in the area of air treatment, while differentiating between indoor air treatment and outdoor air treatment. Specific efforts were made to characterize the main challenges and achievements en-route for successful implementation, which were categorized according to mass transport, adsorption of contaminants, quantum efficiency, deactivation, and, no less important, the adherence and the long term stability of the photocatalyst. © 2010 Elsevier B.V. Source

Danino D.,Russell Berrie Nanotechnology Institute
Current Opinion in Colloid and Interface Science | Year: 2012

Cryo-transmission electron microscopy (cryo-TEM) is a powerful method for uncovering the structure of soft nanostructured materials. The method is based on ultra-fast cooling and conversion of a liquid sample to a vitrified (glassy) specimen that can be examined in the TEM. Direct-imaging cryo-TEM discloses both the global supramolecular structure and local aggregate-specific details, at the hydrated state, and at a nanometer resolution. This placed the method as a central characterization tool in colloid, material, bio- and nano-related technologies in academia and industry. The advancement of cryo-TEM to new fields of research has been motivated also by significant improvements in instrumentation and software. In this review, we summarize the primary principles of cryo-TEM and highlight the recent contribution of this method to understanding soft-matter self-assembly. Detailed example address the origin of the viscosity peak in micellar solutions, and the nature of exotic assemblies as branched micelles, and micellar discs and ribbons. We further emphasize the strategic application of direct-imaging cryo-TEM to study fundamental biological processes and structure-function relations using the example of membrane-remodeling proteins involved in fission and fusion. © 2012 Elsevier Ltd. Source

Under water-rich conditions, small amphiphilic and hydrophobic drug molecules self-assemble into supramolecular nanostructures. Thus, substantial modifications in their interaction with cellular structures and the ability to reach intracellular targets could happen. Additionally, drug aggregates could be more toxic than the non-aggregated counterparts, or vice versa. Moreover, since self-aggregation reduces the number of effective "monomeric" molecules that interact with the target, the drug potency could be underestimated. In other cases, the activity could be ascribed to the non-aggregated molecule while it stems from its aggregates. Thus, drug self-assembly could mislead from drug throughput screening assays to advanced preclinical and clinical trials. Finally, aggregates could serve as crystallization nuclei. The impact that this phenomenon has on the biological performance of active compounds, the inconsistent and often controversial nature of the published data and the need for recommendations/guidelines as preamble of more harmonized research protocols to characterize drug self-aggregation were main motivations for this review. First, the key molecular and environmental parameters governing drug self-aggregation, the main drug families for which this phenomenon and the methods used for its characterization are described. Then, promising nanotechnology platforms investigated to prevent/control it towards a more efficient drug development process are briefly discussed. © 2016 Elsevier Ltd. All rights reserved. Source

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