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Deng X.,Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine College | Liang J.,Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine College | Wu F.-S.,Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine College | Li Y.-B.,Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine College | And 2 more authors.
Chinese Journal of Integrative Medicine | Year: 2012

Objective: To observe the influence of Fuzheng Huayu Tablet (FZHYT) on mental state and social activity of patients with post-hepatitis B liver cirrhosis (LC-HB). Methods: Adopting grouped randomized double-blinded control method, 180 LC-HB patients in 3 research centers were distributed to 2 groups, the treated group and the control group, 90 in each group. Patients in the treated group were administered with FZHYT; while those in the control group treated with conventional therapy combined with placebo, the course for all patients were 6 months. Their mental state and social activity were evaluated before treatment, after 3 months' treatment and at terminal of the 6-month therapeutic course by estimating with Zung self-rating anxiety scale (SAS), self-rating depression scale (SDS) and social deficit screening scale (SDSS). Additionally, the basic demographic materials, liver function, cirrhosis index, hepatic and splenic images, blood coagulation function, etc. in the patients were tested and compared as well. Results: As compared with before treatment, the normal rate of SAS and SDS scores increased and the social deficit rate decreased in the treated group significantly after treatment, showing statistical significance (P<0.05 or P<0.01); while in the control group, change was only shown in the social deficit (P<0.01), inter-group comparisons after treatment showed significant differences in all the three indexes (P<0.05 or P<0.01). Additionally, after treatment, levels of liver function, cirrhosis, blood coagulation function and splenomegaly in the treated group were all improved significantly (P<0.05 or P<0.01), and the improvements were better than those in the control group (P<0.01) in levels of total bilirubin (TBIL), albumin (ALB), type IV collagen (IV -C), prothrombin time (PT), prothrombin activity (PTA). Conclusion: Most patients of LC-HB have mental disturbance and social activity deficit, which could definitely be improved by intervention with Chinese FZHYT. © 2012 The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg. Source

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