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São Paulo, Brazil

Bellei N.,Rua Pedro de Toledo | Bellei N.,Federal University of Sao Paulo
Jornal Brasileiro de Patologia e Medicina Laboratorial | Year: 2011

The swine origin influenza virus A/CALIFORNIA/04/2009 (H1N1) was first detected in Mexico and determined the 2009 influenza pandemic. In August 2010, World Health Organization (WHO) declared the beginning of the post-pandemic period. This last pandemic was distinctly different from previous ones. The virus emerged from genetic rearrangement in non-human mammalian host. Moreover, its inter-species transmission is fully reported. However, it affected human population differently from previous pandemic viruses (1918, 1957, 1968), with increased morbidity and mortality among children and young adults. Currently, the virus has a seasonal pattern in the same way as influenza A H3N2 and influenza B, maintaining the same pathogenicity profile, clinical spectrum and sensitivity to antiviral agents. The strain was included in the annual trivalent seasonal vaccine formulation, mainly for risk groups, which are more vulnerable to complications caused by different influenza strains. Source


Cortez A.P.B.,Rua Pedro de Toledo | De Morais M.B.,Rua Pedro de Toledo | Speridiao P.D.G.L.,Adolescent Health | Da Motta Mattar R.H.G.,Rua Pedro de Toledo | And 2 more authors.
Journal of Clinical Gastroenterology | Year: 2010

OBJECTIVE: To evaluate the food intake, anthropometry, body composition, and sexual maturity of children and adolescents with autoimmune hepatitis. METHODS: Thirty-seven children and adolescents with autoimmune hepatitis were studied. A questionnaire was given to evaluate food intake over a 24-hour period. Weight, height, and skin-fold thickness were measured. Electric impedance and skin-fold using Slaughter formula were used to evaluate body composition. Sexual maturity was evaluated using the Tanner stage method. Cumulative intake of corticosteroids was determined based on medical records. Results: Most of the subjects were females (83.3%). Food intake did not meet recommended dietary intakes for energy, calcium, and vitamin A for 43.2%, 94.6%, and 59.4% of the patients, respectively. All subjects were in their respective pubertal developmental stage. A lower Z score for height-for-age (<-2.0 standard deviation) was found in 3/37 (10.5%) of the patients. Body fat over 30% was found in female patients by bioimpedance (41.9%) and skin-fold (45.2%) evaluation. There was a positive correlation between the 2 methods of measuring body fat (r=+0.800; P<0.001). A larger reduction (P<0.005) in Z score for height-for-age was observed in patients that received a cumulative dose of corticosteroids of more than 10.0g. Conclusions: Food intake in children and adolescents with autoimmune hepatitis is below recommended standards especially for energy, calcium, and vitamin A. Cumulative dose of corticoids was associated with reduction of Z score for height-for-age. © 2010 by Lippincott Williams & Wilkins. Source

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