Donato F.,Federal University of Pampa |
Pavin N.F.,Federal University of Pampa |
Goes A.T.R.,Programa de Posgraduac ao em Bioquimica UNIPAMPA |
Goes A.T.R.,Rua Luiz Joaquim de Sa Britto |
And 6 more authors.
Pharmaceutical Biology | Year: 2015
Context: The organoselenium compounds have been described to demonstrate several biological activities, including pain management. Objective: This study investigated the antinociceptive, hyperalgesic, and toxic effects of oral administration of bis(4-methylbenzoyl) diselenide (BMD) in mice. Materials and methods: The antinociceptive and anti-hyperalgesic effects of BMD (1, 5, 10, 25, and 50 mg/kg, p.o.) were evaluated using models of nociception: formalin, capsaicin, bradykinin (BK), cinnamaldehyde, phorbol myristate acetate (PMA), 8-bromo-cAM, and glutamate-induced nociception; and mechanical hyperalgesia induced by carrageenan (Cg) or complete Freund's adjuvant (CFA). The acute toxicity was evaluated by biochemical markers for hepatic and renal damages. Results: BMD significantly inhibited the licking time of the injected paw in the early and late phases of a formalin test with ED50 values of 14.2 and 10.8 mg/kg, respectively. This compound reduced nociception produced by capsaicin (ED50 of 32.5 mg/kg), BK (ED50 of 24.6 mg/kg), glutamate (ED50 of 28.7 mg/kg), cinnamaldehyde (ED50 of 18.9 mg/kg), PMA (ED50 of 9.6 mg/kg), and 8-bromo-cAMP (ED50 of 24.8 mg/kg). In the glutamate test, the pretreatment with nitric oxide (NO) precursor, L-arginine, reversed antinociception caused by BMD or Nω-nitro-L-arginine (L-NOARG), but the effect of BMD was not abolished by naloxone. Mechanical hyperalgesia induced by Cg and CFA was attenuated by BMD, 70 ± 4% and 65 ± 4%, respectively. Furthermore, a single oral dose of BMD did not change plasma aspartate (AST) and alanine aminotransferase (ALT) activities or urea and creatinine levels. Conclusion: BMD demonstrated as a promising compound because of the antinociceptive and anti-hyperalgesic properties in mice. © 2014 Informa Healthcare USA, Inc.
Alves G.S.,Rua Luiz Joaquim de Sa Britto |
Tartaglia F.L.,Rua Luiz Joaquim de Sa Britto |
Rosa J.C.,CEULJI ULBRA |
de Lima P.C.,Rua Luiz Joaquim de Sa Britto |
And 2 more authors.
Revista Brasileira de Engenharia Agricola e Ambiental | Year: 2013
The objective of this study was to determine the periods of weed interference in sunflower cultivation, and its effects on the head diameter, oil content, oil yield and its productivity. The experimental design was in the randomized blocks with three replications. The treatments were arranged in a factorial 2 x 2 x 5, with the following factors: cultivar (Embrapa 122 and Hélio 358), modality of competition (in the presence and absence of weeds) and periods of coexistence and control of weed from the emergence until the 15, 30, 45, 60 and 110 days. The measured variables were head diameter, oil content, oil yield and productivity. Weeds interfere negatively in the head diameter, in the productivity, and in the yield of oil, but the coexistence with the weeds increases the oil content of seeds, as well as reduces in 76.83 and 92.68% the productivity of cultivars Embrapa 122 and Hélio 358, respectively. Assuming a 10% loss in productivity, the PAI, PTPI and the critical period of prevention and interference (PCPI) for the cultivar Embrapa 122 were 16, 37 and 21 days, respectively. For the hybrid Hélio 358 the period before interference (PAI), the PTPI and the PCPI were 24, 43 and 19 days, respectively.
Alves G.S.,Federal Rural University of Pernambuco |
Tartaglia F.L.,Federal University of Santa Maria |
Ferreira M.M.,Rua Luiz Joaquim de Sa Britto |
Beutler A.N.,Rua Luiz Joaquim de Sa Britto |
Dos Santos E.C.,UFERSA
Revista Caatinga | Year: 2015
The population density is one of the factors that affect the final yield of crops, being easily ma-nipulated by man. The objective was to evaluate the growth of castor bean plants cv BRS Energia in dense pop-ulations through primary data and non-destructive analysis of growth and identify which period greater vegeta-tive growth occurs. We adopted a randomized block design with five treatments and four replications, totaling 20 experimental units. Each experimental unit contained 4 m wide and 6 m in length, representing 24 m2. Treatments involving five populations of plants 10.000; 16.666; 25.000; 50.000; 100.000 plants ha-1, with a spacing of 1 m between rows and 1; 0.6; 0.4; 0.2 and 0.1 m between plants, respectively. It was determined: stem diameter, plant height, leaf area, leaf area index and rates absolute and relative leaf growth, of stem diam-eter, of plant height and of fresh biomass epigeal. The castor bean BRS Energia has the highest rates of vegeta-tive increase between 15 and 45 days after emergence. Therefore, it is of great importance, in this period, pro-vide the plant water and nutrient conditions appropriate so that does not compromise on plant development. © 2015, Universidade Federal Rural do Semi-Arid. All rights reserved.
da Silva J.A.,EAGRO UFRR |
de Oliveira A.P.,Federal University of Paraiba |
Alves G.S.,Rua Luiz Joaquim de Sa Britto |
Cavalcante L.F.,Federal University of Paraiba |
And 2 more authors.
Revista Brasileira de Engenharia Agricola e Ambiental | Year: 2012
The objective of this study was to evaluate the yam yield, cultivar Da Costa, fertilized with bovine manure doses and biofertilizer. The experimental design was randomized blocks, in subdivided plots 6 × 2 + 1 with three repetitions. In plots six doses of cattle manure (0; 6; 12; 18; 24 and 30 t ha-1) were tested, factorially combined with the presence and absence of biofertilizer and in subplots, two forms of application of biofertilizer in the soil and by spray on the leaf and an additional treatment with conventional fertilization (animal manure and NPK). The doses of 30 t ha-1 of bovine manure and the biofertilizer which was applied in the soil and leaf produced tubers with ideal average weight for the commercialization. The bovine manure in doses of 19.2 t ha-1 and in the absence of biofertilizer provided maximum productivity of 20.3 t ha-1 of commercial tubers. Subplots in which the biofertilizer was applied to the soil and leaf, the dose of 30 t ha-1 of cattle manure was responsible, respectively, for maximum yields of 22.8 and 24 t ha-1 of commercial tubers. The organic and conventional fertilizations did not cause any significant change in the mean tuber weight, but the conventional fertilization increased the productivity of commercial tuber.
Formal trade and profile of consumers of medicinal plants and phytomedicine in itaqui municipality, rio grande do sul state, Brazil [Comércio formal e perfil de consumidores de plantas medicinais e fitoterápicos no município de itaqui - RS]
Ethur L.Z.,Rua Luiz Joaquim de Sa Britto |
Jobim J.C.,Rua Luiz Joaquim de Sa Britto |
Ritter J.G.,Rua Luiz Joaquim de Sa Britto |
Oliveira G.,Rua Luiz Joaquim de Sa Britto |
Trindade B.S.,Rua Luiz Joaquim de Sa Britto
Revista Brasileira de Plantas Medicinais | Year: 2011
Formal trade and profile of consumers of medicinal plants and phytomedicine in Itaqui Municipality, Rio Grande do Sul State, Brazil. This study aimed to make a diagnosis of consumers of medicinal plants and phytomedicine, also addressing some aspects related to trade in Itaqui Municipality, Rio Grande do Sul State, Brazil. Data collection was performed in two complementary stages focusing on consumers and stores, especially drugstores. First, the profile of medicinal plant users was diagnosed through a semi-structured questionnaire which was applied to 183 people approached in areas frequently visited by inhabitants from different villages of the municipality; in the second stage, the trade and the view of formal trade was evaluated in the eight drugstores of the municipality. The results of interviews to build the profile of medicinal plant users showed that 71% interviewees were between 21 and 60 years old and most of them had monthly income of up to three minimum wages; as to the use of plants in folk medicine, around 82% stated to have had efficiency and, in cases of health problems, 47% searched for these plants; as regards cultivation, 55% interviewees cultivated medicinal plants in their houses. The second stage, carried out in drugstores, also indicated that phytomedicines and medicinal plants were purchased mostly by women, 75% adults and 25% elderly. The most sold teas were slimming and digestive teas, and the value paid for this type of product was between R$ 1.00 and R$ 3.00. In conclusion, there is market for medicinal plants and phytomedicine and there is also the need for further information related to their cultivation form and proper botanical identification, as well as information to users, quality and efficacy of products, and their use.