O'Connor S.K.,University of North Carolina at Chapel Hill |
O'Connor S.K.,Kerr Drug Inc. |
Ferreri S.P.,University of North Carolina at Chapel Hill |
Ferreri S.P.,Kerr Drug Inc. |
And 7 more authors.
Pharmacogenomics | Year: 2012
Aim: To describe the exploratory planning and implementation of a pilot pharmacogenetic program in a community pharmacy. An institutional review board-approved protocol for a clopidogrel pharmacogenetic program in a community pharmacy was developed to address feasibility and evaluate the pilot program. Study concept: Subjects taking clopidogrel are asked to participate at the point of medication dispensing. A pharmacist schedules an appointment with subjects to discuss the study and collects a buccal swab sample for CYP2C19 testing. When the results are available, the pharmacist consults with the subject's prescriber regarding test result interpretation and associated recommendations, and schedules a second appointment with the participant to discuss results and review any physician-approved therapeutic changes. The intervention-associated consultation is then billed to the subject's insurance. Results: Subject enrollment has begun. Conclusion: Community pharmacists may be valuable partners in pharmacogenetics. © 2012 Future Medicine Ltd.
Sardi C.,Neuroscience Institute |
Sardi C.,Humanitas Clinical and Research Center |
Zambusi L.,Neuroscience Institute |
Zambusi L.,University of Milan |
And 14 more authors.
Journal of Neuroimmunology | Year: 2014
Calcitonin Gene-Related Peptide (CGRP) inhibits microglia inflammatory activation in vitro. We here analyzed the involvement of CGRP and Receptor Component Protein (RCP) in experimental autoimmune encephalomyelitis (EAE).Alpha-CGRP deficiency increased EAE scores which followed the scale alpha-CGRP null. >. heterozygote. >. wild type. In wild type mice, CGRP delivery into the cerebrospinal fluid (CSF) 1) reduced chronic EAE (C-EAE) signs, 2) inhibited microglia activation (revealed by quantitative shape analysis), and 3) did not alter GFAP expression, cell density, lymphocyte infiltration, and peripheral lymphocyte production of IFN-gamma, TNF-alpha, IL-17, IL-2, and IL-4.RCP (probe for receptor involvement) was expressed in white matter microglia, astrocytes, oligodendrocytes, and vascular-endothelial cells: in EAE, also in infiltrating lymphocytes. In relapsing-remitting EAE (R-EAE) RCP increased during relapse, without correlation with lymphocyte density. RCP nuclear localization (stimulated by CGRP in vitro) was I) increased in microglia and decreased in astrocytes (R-EAE), and II) increased in microglia by CGRP CSF delivery (C-EAE). Calcitonin like receptor was rarely localized in nuclei of control and relapse mice. CGRP increased in motoneurons.In conclusion, CGRP can inhibit microglia activation in vivo in EAE. CGRP and its receptor may represent novel protective factors in EAE, apparently acting through the differential cell-specific intracellular translocation of RCP. © 2014 Elsevier B.V.
Critical Control & Safety (SIL-3) Applications System Architecture Unlike other systems,theRTP3000was designed tomeet the stringent requirements of IEC61508 2010 without later additions or modifications. The product requirements contained two other major items, thefunctionality of a DCSand the speed of a PLC ...
Reduced Capital Costs 40% Less than conventional DCS Systems Site License on Comprehensive Software Suite Reduced Operating Costs Free Software Updates Free Technical Support Improved ROI Advanced diagnostics on the RTP 3000 assure that every decision is correct before a decision is implemented. Triplicate I/O communications travel over redundant 100 Mbit networks with multiple embedded CRC error checking routines to Chassis Processors in each chassis where output voting occurs Chassis Processors communicate duplicate output messages to the output module where they are compared before being acted upon Data Acquisition and Control Since 1968 RTP Corp ...
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