Raleigh, NC, United States
Raleigh, NC, United States

RTI International is a nonprofit organization headquartered in the Research Triangle Park in North Carolina that provides research and technical services. It was founded in 1958 with $500,000 in funding by local businesses and the three North Carolina universities in the Research Triangle region. RTI started with departments for research in isotopes, operational science and statistics. It restructured into four departments in 1971 and later created the Office for International Projects, now called the International Development Group. RTI later split into eleven departments, including Health Research, Drug Discovery & Development, Education & Training Research, Survey Research, among others. The US Agency for International Development has come to account for 35 percent of RTI's research revenue. RTI research has covered HIV/AIDS, healthcare, education curriculum and the environment, among others. Wikipedia.


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Grant
Agency: Department of Defense | Branch: Navy | Program: STTR | Phase: Phase I | Award Amount: 79.99K | Year: 2016

High power, high voltage switching via semiconductor materials is attractive from a size, weight, and profile perspective. The Baliga figure of merit for high voltage for Ga2O3 is 3,415 (relative to Si), which suggests this material is well-suited for power device applications. Kyma Technologies proposes to design a deposition system capable of growing monoclinic beta-polytype Ga2O3, and n-type and p-type layers. The deposition rates will be > 4 um/hr; this lends itself to halide vapor phase epitaxy (HVPE), and has already been successfully accomplished elsewhere. This work will build on Kymas extensive experience designing, building and deploying HVPE for GaN and AlN.


Grant
Agency: Department of Defense | Branch: Defense Advanced Research Projects Agency | Program: STTR | Phase: Phase I | Award Amount: 100.00K | Year: 2014

There is an acute need for low-power, low-cost, portable mid-wave infrared (MWIR) thermal imaging systems. Current HgCdTe focal plane array (FPA) detectors have high fabrication cost and require low operating temperature. Recent advances in quantum dot (Q


McCall N.,Rti International | Cromwell J.,University of Massachusetts Boston
New England Journal of Medicine | Year: 2011

BACKGROUND: In the Medicare Modernization Act of 2003, Congress required the Centers for Medicare and Medicaid Services to test the commercial disease-management model in the Medicare fee-for-service program. METHODS: The Medicare Health Support Pilot Program was a large, randomized study of eight commercial programs for disease management that used nurse-based call centers. We randomly assigned patients with heart failure, diabetes, or both to the intervention or to usual care (control) and compared them with the use of a difference-indifferences method to evaluate the effects of the commercial programs on the quality of clinical care, acute care utilization, and Medicare expenditures for Medicare fee-for-service beneficiaries. RESULTS: The study included 242,417 patients (163,107 in the intervention group and 79,310 in the control group). The eight commercial disease-management programs did not reduce hospital admissions or emergency room visits, as compared with usual care. We observed only 14 significant improvements in process-of-care measures out of 40 comparisons. These modest improvements came at substantial cost to the Medicare program in fees paid to the disease-management companies ($400 million), with no demonstrable savings in Medicare expenditures. CONCLUSIONS: In this large study, commercial disease-management programs using nurse-based call centers achieved only modest improvements in quality-of-care measures, with no demonstrable reduction in the utilization of acute care or the costs of care. Copyright © 2011 Massachusetts Medical Society.


Patent
Aramco Services Company and Rti International | Date: 2014-07-17

A polymer-encapsulated mineral acid solution and a method for forming the polymer-encapsulated mineral acid solution. Introducing a strong mineral acid solution to a monomer solution occurs such that a primary emulsion that is a water-in-oil type emulsion forms. Introducing the primary emulsion to a second aqueous solution forms a secondary emulsion that is a water-in-oil-in-water type double emulsion. The monomer in the secondary emulsion is cured such a polymerized shell forms that encapsulates the strong mineral acid solution and forms the capsule. The strong mineral acid solution has up to 30 wt. % strong mineral acid. A method of stimulating a hydrocarbon-bearing formation using the polymer-encapsulated mineral acid solution includes introducing a capsule suspension into a fissure in the hydrocarbon-bearing formation to be stimulated through a face in a well bore. The capsule is maintained within the fissure until the polymer shell degrades.


Tyl R.W.,Rti International
Seminars in Fetal and Neonatal Medicine | Year: 2014

Bisphenol A (BPA), synthesized in 1891, is produced in quantities of >2 million metric tons annually for polycarbonate plastics, epoxy resins and food contact applications. BPA can be a weak estrogen mimic, and is ubiquitous in humans (in 93% US population; in 96% US pregnant women). European/US food/drug agencies conclude that current BPA levels present no risk to the general population (some include infants/children); basic endocrine disruption (ED) researchers state that entire populations are at risk from these levels. The US Food and Drug Administration banned BPA in baby bottles in 2012 'not based on safety concerns'; the US Environmental Protection Agency and its UK counterpart concurred. Basic ED researchers report reproductive/developmental effects from perinatal BPA exposure in mice at very low doses, e.g. 2 ng/g body weight (0.002 mg/kg body weight), with non-monotonic dose-response (NMDR) curves, using few animals per group and few groups; contract research organizations, in good laboratory practice- and guideline-compliant large studies in rats and mice, report no low-dose effects or NMDR curves. The argument rages! © 2014 Elsevier Ltd.


Graber M.L.,Rti International
BMJ Quality and Safety | Year: 2013

A wide variety of research studies suggest that breakdowns in the diagnostic process result in a staggering toll of harm and patient deaths. These include autopsy studies, case reviews, surveys of patient and physicians, voluntary reporting systems, using standardised patients, second reviews, diagnostic testing audits and closed claims reviews. Although these different approaches provide important information and unique insights regarding diagnostic errors, each has limitations and none is well suited to establishing the incidence of diagnostic error in actual practice, or the aggregate rate of error and harm. We argue that being able to measure the incidence of diagnostic error is essential to enable research studies on diagnostic error, and to initiate quality improvement projects aimed at reducing the risk of error and harm. Three approaches appear most promising in this regard: (1) using 'trigger tools' to identify from electronic health records cases at high risk for diagnostic error; (2) using standardised patients (secret shoppers) to study the rate of error in practice; (3) encouraging both patients and physicians to voluntarily report errors they encounter, and facilitating this process.


Hickey A.J.,Rti International
Journal of Controlled Release | Year: 2014

There is increasing interest in the delivery of drugs to the lungs to treat a variety of diseases. The spatial and temporal influence of deposition and clearance mechanisms on the fate of inhaled materials are important factors in the control of delivery of therapeutic agents to the lungs. Balancing anatomical and physiological considerations with pharmaceutical properties dictates the therapeutic potential of any pharmacological and immunological strategy. A brief introduction of aerosol properties and inhaler technology is followed by considerations of in vitro and in vivo disposition in the context of controlled drug release for achieving anatomical, physiological and therapeutic targeting. Comprehensive assessment of drug delivery to, and disposition from, the lungs is required if controlled and targeted strategies are to be successful. © 2014 Elsevier B.V.


Patent
Rti International | Date: 2014-05-16

A method is provided of non-destructively inspecting titanium alloy articles in the as-cast condition using ultrasonic waves to detect internal flaws, comprising modification of grain structure in the as-solidified ingot structure by the addition of trace boron to various titanium alloys. The ability to ultrasonically inspect as-cast billets combined with improved hot workability provided by trace boron enhancement permits an economical method of manufacture of titanium alloy articles destined for high performance applications.


A titanium alloy may be characterized by a good oxidation resistance, high strength and creep resistance at elevated temperatures up to 750C, and good cold/hot forming ability, good superplastic forming performance, and good weldability. The alloy may contain, in weight percent, aluminum 4.5 to 7.5, tin 2.0 to 8.0, niobium 1.5 to 6.5, molybdenum 0.1 to 2.5, silicon 0.1 to 0.6, oxygen up to 0.20, carbon up to 0.10, and balance titanium with incidental impurities.


Patent
Rti International | Date: 2015-04-28

A titanium alloy, components formed thereof, and methods of use are provided. Embodiments of the alloy may be useful in the energy extraction environment. Components formed of the alloy may include subsea or land-based components associated with oil and gas production and drilling.

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