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Patent
RSR Limited | Date: 2017-04-19

A mutant thyroid stimulating hormone receptor (TSHR) or fragment thereof comprises one or more mutations, wherein the mutant TSHR has increased thermostability with respect to the equivalent wild type TSHR or fragment. The one or more mutation is preferably within the extracellular leucine-rich repeat domain (LRD) of the TSHR, or within residues 22 to 260 (TSHR260) of the TSHR, or may be in the transmembrane domain (TMD), A mutant TSHR or fragment thereof of the invention preferably consists of, or consists essentially of, the subdomain TSHR260 of the TSHR receptor. A mutant TSHR or fragment thereof according to the invention has a greater thermostability than the equivalent wild type TSHR or fragment as determined by its half-life at a given temperature, and can be purified whilst retaining activity. A mutant TSHR or fragment thereof according to the invention may also be deglycosylated whilst retaining activity. Methods, kits and uses employing the mutant TSHR or fragment thereof according to the invention are also provided.


News Article | April 27, 2017
Site: news.yahoo.com

Here's a remarkable find–a brand-new 1993 Porsche 911 Carrera RSR. Though this RSR looks pretty grimy in pictures, it's actually as close to a brand-new car as you can get, with only 10 km on its odometer. The car still wears its factory-applied cosmoline rust protection-it's that unmolested. It's headed to RM Sotheby's Villa Erba event next month, and while the auction house doesn't provide an estimated value, it'll likely command a six-figure price. This car's incredibly low mileage isn't the only thing that makes it unique. It's one of only 51 964 Carrera RSRs ever built, and this one features some rather peculiar options. The RSR was built as a track-ready beast, but in spite of that, the original customer specified it with a full red leather interior. The purple Speedline three-piece wheels and gold brake calipers confirm it: This car was ordered by someone with very eccentric tastes The 964 Carrera RSR combined the 911 Turbo's wide body with a 3.8-liter naturally aspirated flat-six that pumps out an impressive 350 horsepower. Other RSRs went on to earn class wins at Le Mans, Daytona, and Sebring while this silver example languished unused. While this example is as close to brand-new as a car from 1993 can get, it will need some work if the buyer intends on driving it. Cars aren't meant to sit this long without being driven. We're not entirely sure why someone would order such an oddly specific, wildly expensive car from Porsche and never ever drive it. Regardless, we we urge the next owner to drive this car, or at least clean it up. It deserves better. You Might Also Like


Patent
RSR Limited | Date: 2015-07-02

According to one aspect there is provided An isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on TSHR constitutive activity wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR.


A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising [antigenic molecule of first source]-[analyte auto antibody]-[antigenic molecule of second source]. The antigenic molecule of first source is immobilised to a solid phase, the second is labelled.


A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising [antigenic molecule of first source]-[analyte auto antibody]-[antigenic molecule of second source]. The antigenic molecule of first source is immobilised to a solid phase, the second is labeled.


Patent
RSR Limited | Date: 2013-07-24

According to one aspect there is provided An isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on the TSHR constitutive activity wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR.


A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising `antigenic molecule of fist source!-`analyte auto antibody!-`antigenic molecule of second source! The antigenic molecule of first source is immobilised to a solid phase, the second is labeled.


The present invention is concerned with epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto.


Patent
RSR Limited | Date: 2013-07-24

According to one aspect there is provided An isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on the TSHR constitutive activity wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR.


Patent
RSR Limited | Date: 2013-07-24

This invention relates to a crystallisable composition comprising a TSHR polypeptide, to crystals comparing a TSHR polypeptide and to TSHR-related applications.

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