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Mhaidat N.M.,Jordan University of Science and Technology | Alshogran O.Y.,Jordan University of Science and Technology | Khabour O.F.,Jordan University of Science and Technology | Alzoubi K.H.,Jordan University of Science and Technology | And 4 more authors.
Journal of Experimental and Clinical Cancer Research | Year: 2011

Background: The human multi-drug resistance gene (MDR1), which encodes the major trans-membrane transporter P-glycoprotein (P-gp), was found to be associated with susceptibility to cancer and response to chemotherapy. The C3435T Polymorphism of MDR1 gene was correlated with expression levels and functions of P-gp. Here, we studied the association between MDR1 C3435T polymorphism and susceptibility to Hodgkin lymphoma (HL) and patient's response to ABVD chemotherapy regimen. Methods. a total of 130 paraffin embedded tissue samples collected from HL patients were analyzed to identify the C3435T polymorphism. As a control group, 120 healthy subjects were enrolled in the study. The C3435T Polymorphism was genotyped by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method. Data analysis was carried out using the statistical package SPSS version 17 to compute all descriptive statistics. Chi-square and Fisher exact tests were used to evaluate the genotype distribution and allele frequencies of the studied polymorphism. Results: these studies revealed that the frequency of T allele was significantly higher in HL patients compared to the controls (P < 0.05). In addition, the frequency of CT and TT genotypes were also significantly higher in HL patients compared to the controls (P < 0.05). No association between C3435T polymorphism and response to ABVD was detected among HL patients (P > 0.05). Conclusions: these results suggest that MDR1 C3435T polymorphism might play a role in HL occurrence; however this polymorphism is not correlated with the clinical response to ABVD. © 2011 Mhaidat et al; licensee BioMed Central Ltd.


Rihani F.B.,Jordanian Royal Medical Services
BMJ case reports | Year: 2013

Oral granuloma gravidarum (OGG) is a distinct clinical entity used to describe pyogenic granuloma developing mainly on the gingiva of pregnant women, possibly propagated by gingival high levels of active progesterone and poor oral hygiene. We report herein a 41-year-old woman presented 7 months after childbirth with two painless masses of OGG in mandibular gingiva that developed at the end of first trimester and increased gradually in size even after delivery. Surgical excisional biopsy was performed under general anaesthesia with extraction of periodontally involved mandibular anterior teeth. Proper oral hygiene in pregnant women is mandatory to prevent such oral condition.


Rihani F.B.,Jordanian Royal Medical Services | Ersheidat A.A.,Jordanian Royal Medical Services | Alsmadi H.F.,Jordanian Royal Medical Services | Al-Nahar L.A.,Jordanian Royal Medical Services
BMJ Case Reports | Year: 2013

Oral granuloma gravidarum (OGG) is a distinct clinical entity used to describe pyogenic granuloma developing mainly on the gingiva of pregnant women, possibly propagated by gingival high levels of active progesterone and poor oral hygiene. We report herein a 41-year-old woman presented 7 months after childbirth with two painless masses of OGG in mandibular gingiva that developed at the end of first trimester and increased gradually in size even after delivery. Surgical excisional biopsy was performed under general anaesthesia with extraction of periodontally involved mandibular anterior teeth. Proper oral hygiene in pregnant women is mandatory to prevent such oral condition. Copyright 2013 BMJ Publishing Group. All rights reserved.


Rihani F.B.,Jordanian Royal Medical Services
BMJ case reports | Year: 2013

We describe a girl presented with facial asymmetry and oral mucosal cleft and with further investigations other anomalies were found including hearing loss, Duane syndrome, Klippel-Feil anomaly, Chiari malformation and accessory bone mass in mandibular ramus leading to the clinical diagnosis of cervico-oculo-acoustic (Wildervanck) syndrome (COAS). The patient underwent surgical occipital decompression by preforming suboccipital craniectomy and C1 posterior laminectomy to relieve the cerebellar tonsillar herniation. Surgical removal of mandibular bony mass was done and the patient is now under orthodontic treatment to correct facial asymmetry and malocclusion.


Rihani F.B.,Jordanian Royal Medical Services
BMJ Case Reports | Year: 2013

We describe a girl presented with facial asymmetry and oral mucosal cleft and with further investigations other anomalies were found including hearing loss, Duane syndrome, Klippel-Feil anomaly, Chiari malformation and accessory bone mass in mandibular ramus leading to the clinical diagnosis of cervico-oculo-acoustic (Wildervanck) syndrome (COAS). The patient underwent surgical occipital decompression by preforming suboccipital craniectomy and C1 posterior laminectomy to relieve the cerebellar tonsillar herniation. Surgical removal of mandibular bony mass was done and the patient is now under orthodontic treatment to correct facial asymmetry and malocclusion.


Mohammed Aldabbas R.,Jordanian Royal Medical Services
Rawal Medical Journal | Year: 2013

Colorectal carcinomas most often metastasize to the liver and lung, whether by hematogenous or lymphatic spread. Metastasis to other sites has been reported in the literature but is extremely rare. We are reporting a case of a 65 year old male who was being treated at King Hussein Medical Center as a case of primary nasopharyngeal carcinoma for five years, only to be later discovered that he actually suffers from a primary sigmoid tumor with distant nasopharyngeal metastasis. Metastatic nasopharyngeal tumor of colonic origin is very infrequent and is even indistinguishable from a primary tumor by routine pathological studies (1).


Dajaa M.,Jordanian Royal Medical Services | Alibrahim A.,Jordanian Royal Medical Services | Khasawneh G.,Jordanian Royal Medical Services | Gora A.A.,Jordanian Royal Medical Services | Al-Mefleh W.,Jordanian Royal Medical Services
Rawal Medical Journal | Year: 2016

Objective: To report our success rate, complications and cosmetic results with distal penile hypospadias treated by tabularized incised plate urethroplasty. Methodology: This retrospective study was done at Prince Rashid bin Alhassan Hospital from June 2011 to April 12013 and included 83 patients with distal penile hypospadias who underwent tabularized incised plate urethroplasy for the first time. All patients were followed for up 24 months after surgery. Results: Patients age ranged from 2-8 years; mean age was 4 years. 69 (83%) patients had excellent functional and cosmetic results without any complications. Complications were seen in 14 patients. Urethrocatanous fistula was seen in 8 (10%) patients, meatal stenosis in 2 (2.4%), complete disruption of the glans in 1 (1.2%) and penile rotation was seen in 3 (3.6%) patients. Conclusion: Tabularized incised plate urethroplasty for distal penile hypospadias repair resulted in excellent functional neourethra, excellent glans and meatus shape and low complications rate. © 2016, Pakistan Medical Association. All rights reserved.


Almaaita T.J.,Jordanian Royal Medical Services | Abdallat S.A.,Jordanian Royal Medical Services
Rawal Medical Journal | Year: 2012

Objective To study the prevalence of common skin conditions in Jordanian children who presented to the Dermatology and Pediatrics clinics at King Hussein Medical Centre (KHMC, Amman, Jordan) and Prince Ali bin Alhussein Hospital (Alkarak, Jordan). Methods This prospective study included all children aged 1 day to 14 years who presented with skin diseases. A good history and thorough physical examination were done with every patient. In some cases, we did scraping, woods light examination, swab culture, baseline blood tests, skin biopsy and other investigations, as needed. Results A total of 1836 patients, with age range of 1 day to14 years (mean age of 7.5 years) were included in the study. Male to female ratio was 1:1.2. The total number of dermatoses found was 2779, as 769 patients presented with more than one dermatosis. Infectious dermatoses were encountered in 46.85% of the cases, and noninfectious dermatoses in 53.15%. Pityriasis alba was the most commonly found condition (27.1%) followed by viral warts (22.4%). Conclusion Noninfectious dermatoses, mainly pitryriasis alba, were the most common skin presentation, followed by infectious dermatoses, mainly viral warts. Parents and patient education about skin care, good hygiene and preventive measures can decrease the prevalence of skin diseases in children.


PubMed | Ibn Alhaytham Hospital, University of Jordan, Jordan University of Science and Technology and Jordanian Royal Medical Services
Type: | Journal: Scoliosis and spinal disorders | Year: 2017

This was a prospective study to evaluate the effect of multilevel vertebral augmentation in addition to conventional therapy in multiple myeloma patients.We treated 27 patients, whom were recently diagnosed to have multiple myeloma by two ways of treatment. Thirteen patients (group I) were treated with conventional therapy and 14 patients (group II) with adding vertebroplasty and kyphoplasty. Patients were evaluated pre-treatment and at half, one, two and 3-years post-treatment by using Oswestry Disability Index (ODI), the Stanford Score (SS) and the Spinal Instability Neoplastic Score (SINS).Mean values of ODI, SS and SINS were 31.9 (63.8%), 4.3 and 13.8 for group I and 33.2 (66.4%), 4.6 and 12.8 for group II before starting treatment. Group II showed improvement better than group I at all follow-up intervals with best results at first 6months. Adding vertebral augmentation to conventional therapy improves multiple myeloma patients quality of life, but didnt affect the mortality rate.


PubMed | Jordanian Royal Medical Services
Type: | Journal: BMJ case reports | Year: 2013

We describe a girl presented with facial asymmetry and oral mucosal cleft and with further investigations other anomalies were found including hearing loss, Duane syndrome, Klippel-Feil anomaly, Chiari malformation and accessory bone mass in mandibular ramus leading to the clinical diagnosis of cervico-oculo-acoustic (Wildervanck) syndrome (COAS). The patient underwent surgical occipital decompression by preforming suboccipital craniectomy and C1 posterior laminectomy to relieve the cerebellar tonsillar herniation. Surgical removal of mandibular bony mass was done and the patient is now under orthodontic treatment to correct facial asymmetry and malocclusion.

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