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Al-Amer R.,University of Western Sydney | Ramjan L.,University of Western Sydney | Glew P.,University of Western Sydney | Darwish M.,Jordanian Royal Medical Services | Salamonson Y.,University of Western Sydney
Journal of Clinical Nursing | Year: 2015

Aims and objectives: To illuminate translation practice in cross-language interview in health care research and its impact on the construction of the data. Background: Globalisation and changing patterns of migration have created changes to the world's demography; this has presented challenges for overarching social domains, specifically, in the health sector. Providing ethno-cultural health services is a timely and central facet in an ever-increasingly diverse world. Nursing and other health sectors employ cross-language research to provide knowledge and understanding of the needs of minority groups, which underpins cultural-sensitive care services. However, when cultural and linguistic differences exist, they pose unique complexities for cross-cultural health care research; particularly in qualitative research where narrative data are central for communication as most participants prefer to tell their story in their native language. Consequently, translation is often unavoidable in order to make a respondent's narrative vivid and comprehensible, yet, there is no consensus about how researchers should address this vital issue. Design: An integrative literature review. Methods: PubMed and CINAHL databases were searched for relevant studies published before January 2014, and hand searched reference lists of studies were selected. Results: This review of cross-language health care studies highlighted three major themes, which identify factors often reported to affect the translation and production of data in cross-language research: (1) translation style; (2) translators; and (3) trustworthiness of the data. Conclusion: A plan detailing the translation process and analysis of health care data must be determined from the study outset to ensure credibility is maintained. A transparent and systematic approach in reporting the translation process not only enhances the integrity of the findings but also provides overall rigour and auditability. Relevance to clinical practice: It is important that minority groups have a voice in health care research which, if accurately translated, will enable nurses to improve culturally relevant care. © 2014 John Wiley & Sons Ltd. Source


Mohammed Aldabbas R.,Jordanian Royal Medical Services
Rawal Medical Journal | Year: 2013

Colorectal carcinomas most often metastasize to the liver and lung, whether by hematogenous or lymphatic spread. Metastasis to other sites has been reported in the literature but is extremely rare. We are reporting a case of a 65 year old male who was being treated at King Hussein Medical Center as a case of primary nasopharyngeal carcinoma for five years, only to be later discovered that he actually suffers from a primary sigmoid tumor with distant nasopharyngeal metastasis. Metastatic nasopharyngeal tumor of colonic origin is very infrequent and is even indistinguishable from a primary tumor by routine pathological studies (1). Source


Rihani F.B.,Jordanian Royal Medical Services
BMJ case reports | Year: 2013

We describe a girl presented with facial asymmetry and oral mucosal cleft and with further investigations other anomalies were found including hearing loss, Duane syndrome, Klippel-Feil anomaly, Chiari malformation and accessory bone mass in mandibular ramus leading to the clinical diagnosis of cervico-oculo-acoustic (Wildervanck) syndrome (COAS). The patient underwent surgical occipital decompression by preforming suboccipital craniectomy and C1 posterior laminectomy to relieve the cerebellar tonsillar herniation. Surgical removal of mandibular bony mass was done and the patient is now under orthodontic treatment to correct facial asymmetry and malocclusion. Source


Rihani F.B.,Jordanian Royal Medical Services
BMJ Case Reports | Year: 2013

We describe a girl presented with facial asymmetry and oral mucosal cleft and with further investigations other anomalies were found including hearing loss, Duane syndrome, Klippel-Feil anomaly, Chiari malformation and accessory bone mass in mandibular ramus leading to the clinical diagnosis of cervico-oculo-acoustic (Wildervanck) syndrome (COAS). The patient underwent surgical occipital decompression by preforming suboccipital craniectomy and C1 posterior laminectomy to relieve the cerebellar tonsillar herniation. Surgical removal of mandibular bony mass was done and the patient is now under orthodontic treatment to correct facial asymmetry and malocclusion. Source


Mhaidat N.M.,Jordan University of Science and Technology | Alshogran O.Y.,Jordan University of Science and Technology | Khabour O.F.,Jordan University of Science and Technology | Alzoubi K.H.,Jordan University of Science and Technology | And 4 more authors.
Journal of Experimental and Clinical Cancer Research | Year: 2011

Background: The human multi-drug resistance gene (MDR1), which encodes the major trans-membrane transporter P-glycoprotein (P-gp), was found to be associated with susceptibility to cancer and response to chemotherapy. The C3435T Polymorphism of MDR1 gene was correlated with expression levels and functions of P-gp. Here, we studied the association between MDR1 C3435T polymorphism and susceptibility to Hodgkin lymphoma (HL) and patient's response to ABVD chemotherapy regimen. Methods. a total of 130 paraffin embedded tissue samples collected from HL patients were analyzed to identify the C3435T polymorphism. As a control group, 120 healthy subjects were enrolled in the study. The C3435T Polymorphism was genotyped by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method. Data analysis was carried out using the statistical package SPSS version 17 to compute all descriptive statistics. Chi-square and Fisher exact tests were used to evaluate the genotype distribution and allele frequencies of the studied polymorphism. Results: these studies revealed that the frequency of T allele was significantly higher in HL patients compared to the controls (P < 0.05). In addition, the frequency of CT and TT genotypes were also significantly higher in HL patients compared to the controls (P < 0.05). No association between C3435T polymorphism and response to ABVD was detected among HL patients (P > 0.05). Conclusions: these results suggest that MDR1 C3435T polymorphism might play a role in HL occurrence; however this polymorphism is not correlated with the clinical response to ABVD. © 2011 Mhaidat et al; licensee BioMed Central Ltd. Source

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