Roxbury Community College

Roxbury, MA, United States

Roxbury Community College

Roxbury, MA, United States
SEARCH FILTERS
Time filter
Source Type

News Article | October 28, 2016
Site: www.prweb.com

Leading online higher education resource provider AffordableCollegesOnline.org has released its rankings of the Best Online Colleges in Massachusetts for 2016-2017. A two- and four-year school list was created for each state, with the following receiving top honors: University of Massachusetts - Lowell, Amherst and Dartmouth campuses, Westfield State University and Lesley University for four-year schools; Bunker Hill Community College, Holyoke Community College, Middlesex Community College, Massasoit Community College and Greenfield Community College for two-year schools. "The Massachusetts Department of Education has been steadily working on initiatives to ramp up college completion numbers by 2025,” said Dan Schuessler, CEO and Founder of AffordableCollegesOnline.org. "These colleges are examples of how higher education in Massachusetts is becoming more flexible, offering affordable, top-quality online learning programs to help more students earn degrees.” To earn a spot on the Best Online Colleges in Massachusetts’s list, schools are required to meet several stringent base qualifications. Each institution must be an accredited, public or private not-for-profit college or university. Schools must also fall within specific affordability guidelines, offering in-state tuition rates below $5,000 annually at two-year schools and below $25,000 annually at four-year schools. A complete lists of colleges on the two- and four-year lists are included below. To learn more about where each specifically falls in the ranking and find more details about the data analysis and methodology used to score each state, visit the following link: The two-year schools honored as the Best Online Colleges in Massachusetts for 2016 are: Berkshire Community College Bristol Community College Bunker Hill Community College Greenfield Community College Holyoke Community College Massachusetts Bay Community College Massasoit Community College Middlesex Community College Northern Essex Community College Roxbury Community College The four-year schools honored as the Best Online Colleges in Massachusetts for 2016 are: Fitchburg State University Framingham State University Hebrew College Lesley University Massachusetts Maritime Academy National Graduate School of Quality Management Salem State University University of Massachusetts - Amherst University of Massachusetts - Boston University of Massachusetts - Dartmouth University of Massachusetts - Lowell Westfield State University AffordableCollegesOnline.org began in 2011 to provide quality data and information about pursuing an affordable higher education. Our free community resource materials and tools span topics such as financial aid and college savings, opportunities for veterans and people with disabilities, and online learning resources. We feature higher education institutions that have developed online learning environments that include highly trained faculty, new technology and resources, and online support services to help students achieve educational and career success. We have been featured by nearly 1,100 postsecondary institutions and nearly 120 government organizations.


Mahajan S.G.,Massachusetts Institute of Technology | Abrahamson J.T.,Massachusetts Institute of Technology | Abrahamson J.T.,University of Minnesota | Birkhimer S.,Massachusetts Institute of Technology | And 5 more authors.
Energy and Environmental Science | Year: 2014

Spatially propagating reaction waves are central to a variety of energy applications, such as high temperature solid phase or combustion synthesis, and thermopower waves. In this paper, we identify and study a previously unreported property of such waves, specifically that they can generate temperatures far in excess of the adiabatic limit. We show that this superadiabaticity occurs when a reaction wave in either one dimension (1D) or two dimensions (2D) impinges upon an adiabatic boundary under specific reaction and heat transfer conditions. This property is studied analytically and computationally for a series of 1D and 2D example systems, producing an estimate of the upper bound for excess temperature rise as high as 1.8 times the adiabatic limit, translating to temperatures approaching 2000 K for some practical materials. We show that superadiabaticity may enable several new types of energy conversion mechanisms, including thermophotovoltaic wave harvesting, which we analyze for efficiency and power density. © The Royal Society of Chemistry 2014.


Low M.,University of Western Sydney | Khoo C.S.,University of Western Sydney | Munch G.,University of Western Sydney | Govindaraghavan S.,Meridian | Sucher N.J.,Roxbury Community College
BMC Complementary and Alternative Medicine | Year: 2015

Background: The anti-inflammatory activity of Andrographis paniculata (Acanthaceae), a traditional medicine widely used in Asia, is commonly attributed to andrographolide, its main secondary metabolite. Commercial A. paniculata extracts are standardised to andrographolide content. We undertook the present study to investigate 1) how selective enrichment of andrographolide in commercial A. paniculata extracts affects the variability of non-standardised phytochemical components and 2) if variability in the non-standardised components of the extract affects the pharmacological activity of andrographolide itself. Methods: We characterized 12 commercial, standardised (≥30% andrographolide) batches of A. paniculata extracts from India by HPLC profiling. We determined the antioxidant capacity of the extracts using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, oxygen radical antioxidant capacity (ORAC) and a Folin-Ciocalteu (FC) antioxidant assays. Their anti-inflammatory activity was assessed by assaying their inhibitory effect on the release of tumor necrosis factor alpha (TNF-α) in the human monocytic cell line THP-1. Results: The andrographolide content in the samples was close to the claimed value (32.2±2.1%, range 27.5 to 35.9%). Twenty-one non-standardised constituents exhibited more than 2-fold variation in HPLC peak intensities in the tested batches. The chlorogenic acid content of the batches varied more than 30-fold. The DPPH free radical scavenging activity varied ~3-fold, the ORAC and FC antioxidant capacity varied ~1.5 fold among batches. In contrast, the TNF-α inhibitory activity of the extracts exhibited little variation and comparison with pure andrographolide indicated that it was mostly due to their andrographolide content. Conclusions: Standardised A. paniculata extracts contained the claimed amount of andrographolide but exhibited considerable phytochemical background variation. DPPH radical scavenging activity of the extracts was mostly due to the flavonoid/phenlycarboxylic acid compounds in the extracts. The inhibitory effect of andrographolide on the release of TNF-α was little affected by the quantitative variation of the non-standardised constituents. © 2015 Low et al.


Shen B.,University of Western Sydney | Truong J.,University of Western Sydney | Helliwell R.,University of Western Sydney | Govindaraghavan S.,Lipa Pharmaceuticals | And 3 more authors.
BMC Complementary and Alternative Medicine | Year: 2013

Background: Age is the leading risk factor for acute and chronic neurodegenerative diseases. The Shen Nong Ben Cao Jing, the oldest known compendium of Chinese materia media, lists herbal medicines that were believed to exert neither fast acting pharmacological effects nor discernible toxicity, but to promote general health and longevity. In modern terms, these herbal medicines could be considered as complementary health care products for prevention rather than treatment of diseases. In the present study, we examined whether a selection of 13 such herbal medicines exhibited neuroprotective activity.Methods: The antioxidant capacity of the herbal extracts was determined using three non-cellular assays measuring the total phenol content (FCR assay), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity and oxygen radical absorbance capacity (ORAC). Cytotoxic effects of the herbal extracts were assayed in cultured mouse cortical neurons and their neuroprotective activities were studied using staurosporine-induced apoptosis of the cultured neurons.Results: Most of the herbal extracts showed negligible toxic effects at 100 μg/ml. However, Polygonum multiflorum and Rhodiola rosea exhibited some neurotoxicity at this concentration. Extracts of Ganoderma lucidum, Glycyrrhiza glabra, Schizandra chinensis, and Polygonum cuspidatum inhibited staurosporine-induced apoptosis by 30 - 50% in a dose-dependent manner. The neuroprotective effects of Polygonum cuspidatum were predominantly due to its major ingredient, resveratrol. The effective herbal extracts showed various levels of reactive oxygen species (ROS) scavenging capacity, which was significantly correlated with their neuro- protective activity. However, P. multiflorum and R. rosea extracts proved to be the exception as they exhibited a high level of antioxidant capacity, but did not exhibit neuroprotective effects in cell-based assay.Conclusions: This in vitro study provides evidence for neuroprotective activity of some Chinese herbal medicines traditionally used to promote healthy ageing and longevity. Our results provide a justification for further study of these herbal extracts in neurodegenerative animal models to assess their safety and effectiveness as a basis for subsequent clinical trials. These herbal medicines might potentially offer a novel preemptive neuroprotective approach in neurodegenerative diseases and might be developed for use in persons at risk. © 2013 Shen et al.; licensee BioMed Central Ltd.


Kulkarni A.,University of Massachusetts Boston | Quang P.,Roxbury Community College | Curry V.,Roxbury Community College | Keyes R.,Roxbury Community College | And 5 more authors.
Chemical Biology and Drug Design | Year: 2014

Phospholipase D enzymes cleave lipid substrates to produce phosphatidic acid, an important precursor for many essential cellular molecules. Phospholipase D is a target to modulate cancer-cell invasiveness. This study reports synthesis of a new class of phospholipase D inhibitors based on 1,3-disubstituted-4-amino-pyrazolopyrimidine core structure. These molecules were synthesized and used to perform initial screening for the inhibition of purified bacterial phospholipase D, which is highly homologous to the human PLD1. Initially tested with the bacterial phospholipase D enzyme, then confirmed with the recombinant human PLD1 and PLD2 enzymes, the molecules presented here exhibited inhibition of phospholipase D activity (IC50) in the low-nanomolar to low-micromolar range with both monomeric substrate diC4PC and phospholipid vesicles and micelles. The data strongly indicate that these inhibitory molecules directly block enzyme/vesicle substrate binding. Preliminary activity studies using recombinant human phospholipase Ds in in vivo cell assays measuring both transphosphatidylation and head-group cleavage indicate inhibition in the mid- to low-nanomolar range for these potent inhibitory novel molecules in a physiological environment. This study reports synthesis of a new class of PLD inhibitors based on 1,3-disubstituted-4-amino-pyrazolopyrimidine core structure. These molecules exhibited inhibition of human recombinant PLD activity (IC 50) in the low-nanomolar to low-micromolar range with monomeric substrate diC4PC and phospholipid vesicles and micelles. Preliminary activity studies using recombinant human PLDs in in vivo cell assays measuring both transphosphatidylation and head-group cleavage indicates inhibition in the mid- to low-nanomolar range for these potent inhibitory novel molecules in a physiological environment. © 2014 John Wiley & Sons A/S.


Gunawardena D.,University of Western Sydney | Karunaweera N.,University of Western Sydney | Lee S.,University of Western Sydney | Van Der Kooy F.,University of Western Sydney | And 6 more authors.
Food and Function | Year: 2015

Chronic inflammation is a contributing factor in many age-related diseases. In a previous study, we have shown that Sri Lankan cinnamon (C. zeylanicum) was one of the most potent anti-inflammatory foods out of 115 foods tested. However, knowledge about the exact nature of the anti-inflammatory compounds and their distribution in the two major cinnamon species used for human consumption is limited. The aim of this investigation was to determine the anti-inflammatory activity of C. zeylanicum and C. cassia and elucidate their main phytochemical compounds. When extracts were tested in LPS and IFN-γ activated RAW 264.7 macrophages, most of the anti-inflammatory activity, measured by down-regulation of nitric oxide and TNF-α production, was observed in the organic extracts. The most abundant compounds in these extracts were E-cinnamaldehyde and o-methoxycinnamaldehyde. The highest concentration of E-cinnamaldehyde was found in the DCM extract of C. zeylanicum or C. cassia (31 and 34 mg g-1 of cinnamon, respectively). When these and other constituents were tested for their anti-inflammatory activity in RAW 264.7 and J774A.1 macrophages, the most potent compounds were E-cinnamaldehyde and o-methoxycinnamaldehyde, which exhibited IC50 values for NO with RAW 264.7 cells of 55 ± 9 μM (7.3 ± 1.2 μg mL-1) and 35 ± 9 μM (5.7 ± 1.5 μg mL-1), respectively; and IC50 values for TNF-α of 63 ± 9 μM (8.3 ± 1.2 μg mL-1) and 78 ± 16 μM (12.6 ± 2.6 μg mL-1), respectively. If therapeutic concentrations can be achieved in target tissues, cinnamon and its components may be useful in the treatment of age-related inflammatory conditions. This journal is © The Royal Society of Chemistry 2015.


Sucher N.J.,Roxbury Community College | Sucher N.J.,Northern Essex Community College
Synergy | Year: 2014

In this paper, I examine the role of the idea of synergy in life science research using examples in the fields of pharmacology/toxicology, molecular genetics and development, biochemistry, ecology and metabolic engineering. The research shows that synergy exhibits scale invariance. Small molecules act synergistically in the activation of single receptor molecules. Proteins function synergistically in development, metabolism and signaling. Synergy was found in the interaction between communities of organisms. Synergy manifests itself quantitatively or qualitatively: synergistic effects can be smaller or larger or they can be entirely different from what was expected. There is no single mathematical model that can be used uniformly to detect and quantify synergy. Synergy provides benefits for human health, wellbeing and economy. Synergy has explanatory and heuristic value in our quest to understand the function of and in designing complex biological systems. © 2014 Elsevier GmbH.


PubMed | University of Massachusetts Boston and Roxbury Community College
Type: Journal Article | Journal: Chemical biology & drug design | Year: 2016

Phospholipase D enzymes cleave phospholipid substrates generating choline and phosphatidic acid. Phospholipase D from Streptomyces chromofuscus is a non-HKD (histidine, lysine, and aspartic acid) phospholipase D as the enzyme is more similar to members of the diverse family of metallo-phosphodiesterase/phosphatase enzymes than phospholipase D enzymes with active site HKD repeats. A highly efficient library of phospholipase D inhibitors based on 1,3-disubstituted-4-amino-pyrazolopyrimidine core structure was utilized to evaluate the inhibition of purified S. chromofuscus phospholipase D. The molecules exhibited inhibition of phospholipase D activity (IC50 ) in the nanomolar range with monomeric substrate diC4 PC and micromolar range with phospholipid micelles and vesicles. Binding studies with vesicle substrate and phospholipase D strongly indicate that these inhibitors directly block enzyme vesicle binding. Following these compelling results as a starting point, sequence searches and alignments with S. chromofuscus phospholipase D have identified potential new drug targets. Using AutoDock, inhibitors were docked into the enzymes selected from sequence searches and alignments (when 3D co-ordinates were available) and results analyzed to develop next-generation inhibitors for new targets. In vitro enzyme activity assays with several human phosphatases demonstrated that the predictive protocol was accurate. The strategy of combining sequence comparison, docking, and high-throughput screening assays has helped to identify new drug targets and provided some insight into how to make potential inhibitors more specific to desired targets.


PubMed | Meridian, Roxbury Community College and University of Western Sydney
Type: | Journal: BMC complementary and alternative medicine | Year: 2015

The anti-inflammatory activity of Andrographis paniculata (Acanthaceae), a traditional medicine widely used in Asia, is commonly attributed to andrographolide, its main secondary metabolite. Commercial A. paniculata extracts are standardised to andrographolide content. We undertook the present study to investigate 1) how selective enrichment of andrographolide in commercial A. paniculata extracts affects the variability of non-standardised phytochemical components and 2) if variability in the non-standardised components of the extract affects the pharmacological activity of andrographolide itself.We characterized 12 commercial, standardised (30% andrographolide) batches of A. paniculata extracts from India by HPLC profiling. We determined the antioxidant capacity of the extracts using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, oxygen radical antioxidant capacity (ORAC) and a Folin-Ciocalteu (FC) antioxidant assays. Their anti-inflammatory activity was assessed by assaying their inhibitory effect on the release of tumor necrosis factor alpha (TNF-) in the human monocytic cell line THP-1.The andrographolide content in the samples was close to the claimed value (32.22.1%, range 27.5 to 35.9%). Twenty-one non-standardised constituents exhibited more than 2-fold variation in HPLC peak intensities in the tested batches. The chlorogenic acid content of the batches varied more than 30-fold. The DPPH free radical scavenging activity varied ~3-fold, the ORAC and FC antioxidant capacity varied ~1.5 fold among batches. In contrast, the TNF- inhibitory activity of the extracts exhibited little variation and comparison with pure andrographolide indicated that it was mostly due to their andrographolide content.Standardised A. paniculata extracts contained the claimed amount of andrographolide but exhibited considerable phytochemical background variation. DPPH radical scavenging activity of the extracts was mostly due to the flavonoid/phenlycarboxylic acid compounds in the extracts. The inhibitory effect of andrographolide on the release of TNF- was little affected by the quantitative variation of the non-standardised constituents.


PubMed | Roxbury Community College
Type: Journal Article | Journal: Epilepsy & behavior : E&B | Year: 2015

Ingredients of commercial herbal medicines are assessed for quality primarily to ensure their safety. However, as complex mixtures of different groups of plant secondary metabolites, retention of overall phytochemical consistency of herbal medicines is pivotal to their efficacy. Authenticity and homogeneity of the herbs and strict regimes of physical processing and extract manufacturing are critical factors to maintain phytochemical consistency in commercial products. To ensure both safety and efficacy of herbal medicines, implementation of and adherence to good agricultural and collection practice (GACP), good plant authentication and identification practice (GPAIP), good manufacturing practice (GMP) before and during the manufacturing process, and good laboratory practice (GLP) in analysis are necessary. Establishment and application of harmonized multilaboratory-validated analytical methods and transparency in the supply (value) chain through vendor audits are additional requirements in quality assurance. In this article, we outline steps of a comprehensive quality assurance paradigm aimed at achieving and maintaining safety, consistent phytochemical composition, and clinical efficacy of ingredients of herbal medicines. This article is part of a Special Issue entitled Botanicals for Epilepsy.

Loading Roxbury Community College collaborators
Loading Roxbury Community College collaborators