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Tarragona, Spain

Rovira i Virgili University is located in the cities of Tarragona and Reus, Catalonia. Its name is in honour to Antoni Rovira i Virgili.The University is a teaching and research institution with centres in Tarragona, Reus, Vila-seca, Tortosa and El Vendrell. Wikipedia.

In recent years, a number of studies have determined the daily intake of various chemical pollutants through the diet. Although the influence of cooking on the concentrations of chemical pollutants in food should not be discarded, in most surveys concerning dietary intake of environmental contaminants, food analyses were performed on uncooked/raw products. However, a very important number of foodstuffs are consumed after being cooked. This paper presents an overview on the available scientific information on the influence of cooking processes on the concentrations of various metals and organic contaminants in foodstuffs. The scientific literature has been reviewed using the PubMed and Scopus databases. Although certain cooking processes could reduce or increase the levels of chemical contaminants in food, it seems that the influence of cooking on the levels of these contaminants depends not only on the particular cooking process, but even more on the specific food item. In general terms, cooking procedures that release or remove fat from the product should tend to reduce the total concentrations of the organic contaminants in the cooked food. © Taylor and Francis Group, LLC. Source

Guarro J.,Rovira i Virgili University
Journal of Antimicrobial Chemotherapy

Clinical experience in the management of opportunistic infections, especially those caused by less common fungi, is, due to their rarity, very scarce; therefore, the most effective treatments remain unknown. The everincreasing numbers of fungal infections due to opportunistic fungi have repeatedly proven the limitations of the antifungal armamentarium. Moreover, some of these fungi, such as Fusarium spp. or Scedosporium spp., are innately resistant to almost all the available antifungal drugs, which makes the development of new and effective therapies a high priority. Since it is difficult to conduct randomized clinical trials in these uncommon mycoses, the use of animal models is a good alternative for evaluating new therapies. This is an extensive review of the numerous studies that have used animal models for this purpose against a significant number of less common fungi. A table describing the different studies performed on the efficacy of the different drugs tested is included for each fungal species. In addition, there is a summary table showing the conclusions that can be derived from the analysis of the studies and listing the drugs that showed the best results. Considering the wide variability in the response to the antifungals that the different strains of a given species can show, the table highlights the drugs that showed positive results using at least two parameters for evaluating efficacy against at least two different strains without showing any negative results. These data can be very useful for guiding the treatment of rare infections when there is very little experience or when controversial results exist, or when treatment fails. © The Author 2011. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. Source

Serratosa F.,Rovira i Virgili University
Pattern Recognition Letters

We present a new algorithm to compute the Graph Edit Distance in a sub-optimal way. We demonstrate that the distance value is exactly the same than the one obtained by the algorithm called Bipartite but with a reduced run time. The only restriction we impose is that the edit costs have to be defined such that the Graph Edit Distance can be really defined as a distance function, that is, the cost of insertion plus deletion of nodes (or arcs) have to be lower or equal than the cost of substitution of nodes (or arcs). Empirical validation shows that higher is the order of the graphs, higher is the obtained Speed up. © 2014 Elsevier B.V. All rights reserved. Source

Guarro J.,Rovira i Virgili University
European Journal of Clinical Microbiology and Infectious Diseases

In recent years the number of opportunistic invasive fusariosis has increased significantly, the main factors involved in these infections being reviewed here. In spite of the extensive literature published the advances in the management of disseminated fusariosis have been very poor and it remains a severe infection, refractory to treatment and with a high mortality rate. There are no ideal therapies and the presence of neutropenia has a critical part to play in the outcome of the infection. At least 70 species have been involved in fusariosis. Fusarium solani species complex is responsible for nearly 60 % of the cases and F. oxysporum species complex for approximately 20 % of them. Most of the infections are caused by four species, i.e. F. petroliphilum, F. keratoplasticum and other two unnamed phylogenetic species. The efficacy of amphotericin B and voriconazole, the most used antifungal drugs, for treating invasive fusariosis are controversial but in general the percentage of patients cured in the different clinical trials is low. Infections by Fusarium verticillioides seem to have the best prognosis. The recent release of complete genome sequences of the most clinically relevant species and the emergence of fungal genomics offer excellent opportunities for examining the multifactorial processes of Fusarium pathogenicity. Using knockout mutants of genes encoding sequence-specific proteins, several virulence factors have been characterized. © 2013 Springer-Verlag Berlin Heidelberg. Source

Boutureira O.,Rovira i Virgili University | Bernardes G.J.L.,University of Cambridge | Bernardes G.J.L.,University of Lisbon
Chemical Reviews

Protein chemical modification is a problem-solving technique in research and technology. Modifications also occur in natural deteriorations. Generally these modifications are with the most reactive side chains and are predominantly oxidations, reductions, and nucleophilic and electrophilic substitutions. Deteriorations include peptide bond scissions, racemizations, β-eliminations, and formation of products by the reaction of proteins with added chemicals. Proteins are modified intentionally for structure-function relationship studies or for development of new and improved products. Although appearing quite varied, the techniques used in pharmacological, food and feed, or other industrial areas differ more operationally than from major differences in the levels of chemical sophistication that are used. Source

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