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Monza, Italy

Cicero A.F.G.,University of Bologna | Benvenuti C.,Rottapharm Madaus SpA
Mediterranean Journal of Nutrition and Metabolism | Year: 2010

To verify the efficacy of a patented proprietary combination of nutraceuticals containing natural hypocholesterolemic and antioxidant agents as red yeast rice extract, policosanols, coenzyme Q10, astaxanthin, and folic acid in the following subgroups of hyperlipidemic subjects: fertile (F) versus menopause (M) women, adults versus elderly (>65 years), lunch versus dinner administration time. A randomised, multicenter study in 411 Italians units compared Armolipid-Rottapharm|Madaus (ARM) one tablet/day plus diet versus diet alone (D) for 16 weeks in hyperlipidemic patients [serum total cholesterol (tot-C) >200 mg/dL or LDL-cholesterol (LDL-C) >150 mg/dL at admission]. Efficacy parameters were measured at baseline and every 4 weeks. In 2,408 eligible subjects, 1,665 adults and 743 elderly, total and LDL-cholesterol were likewise reduced by ARM + D in both age classes and significantly versus D. In 1,246 cases, 302 F and 946 M, tot-C gradually and significantly decreased up to 18.7 and 16.8% in F and M treated groups versus 9% in D group. Similar reduction was observed in LDL-C. In 907 cases, the time of administration of ARM was detailed: 733 received ARM + D at dinner and 174 at lunch. Cholesterolemia improved equally in the two groups. The association of ARM with an appropriate diet is more effective than diet alone in reducing abnormal cholesterolemia, independently from age classes and administration time during the day, supporting its positive use for controlling hypercholesterolemia with a positive impact on CHD prevention in all categories of subjects. © 2010 Springer-Verlag. Source


Cassano N.,University of Bari | Mantegazza R.,Rottapharm Madaus SpA | Battaglini S.,University of Bari | Apruzzi D.,University of Bari | And 2 more authors.
Giornale Italiano di Dermatologia e Venereologia | Year: 2010

Emollients are considered important adjunctive tools for the therapeutic management of psoriasis patients. In spite of the widespread use, the actual impact of emollients on psoriasis is far to be completely elucidated. The objective of this study was to evaluate the effect of a new emollient cream containing milk proteins and Glycyrrhiza glabra extracts in patients with palmar and/or plantar psoriasis treated with topical corticotherapy. This pilot open parallel-group trial was carried out in 40 patients with palmar and/or plantar psoriasis. Patients were randomized to receive monotherapy with mometasone furoate ointment, applied once daily to the palmoplantar lesions until remission and for a maximum of 4 weeks (N=20), or the same topical corticotherapy in combination with the emollient cream (N=20). The emollient was applied twice a day for 4 weeks. Clinical assessments were performed at baseline and 2 and 4 weeks after the start of treatment. All patients completed the study and showed a progressive improvement of their palmo-plantar psoriasis over the treatment period, achieving at week 4 a statistical significant reduction in the severity of all clinical signs (erythema, desquamation and infiltration) and in the surface area affected. The comparison between the two groups showed no differences in the mean average duration of corticosteroid therapy, whereas a significantly greater improvement of desquamation, surface area affected, and subjective symptoms was observed at week 4 in the group treated with the corticotherapy combined with the emollient as compared to patients who received the corticotherapy alone. This pilot experience suggests the importance of the adjuvant role of particular emollients in the management of psoriasis. Source


Murina F.,V. Buzzi Hospital | Murina F.,Rottapharm Madaus SpA | Benvenuti C.,V. Buzzi Hospital | Benvenuti C.,Rottapharm Madaus SpA
Asian Pacific Journal of Reproduction | Year: 2013

Objective: Vulvar dermatoses are characterized by dehydration leading to symptoms as itching and burning. Topical corticosteroids and lanolin cream are the standard therapy. A new non-irritant cleanser based on soft natural surfactants (Saugella idraSerum, a product by Rottapharm Madaus) (SiS) exhibited interesting clinical properties. Purpose of the study was to compare the activity of SiS in vulvar dermatoses versus a common reference cleanser (Aveeno intimo) (Ref). Methods: In a controlled randomized clinical study 32 patients with vulvar dermatosis received Mometasone 2 applications weekly and lanolin cream 1 application daily for 7 days followed by 1 application as needed. To one half of the patients SiS and to half of patients Ref were recommended as daily cleanser bid for 1 month. Any onset of symptoms was checked before and after treatment. Results: Burning improved after SiS treatment vs Ref in a significantly higher rate (respectively 80% vs 25%, P<0.05). Dryness improvement was superior with SiS (81.1% vs 50.0%, P=0.10) though the Ref group applied a significantly higher number of doses of emollient cream as needed. Conclusion: This new-generation intimate cleanser was effective in reducing burning and the concomitant emollient treatment in vulvar dermatoses. © 2013 Hainan Medical College. Source


Pavan M.V.,University of Trieste | Lassiani L.,University of Trieste | Berti F.,University of Trieste | Stefancich G.,University of Trieste | And 9 more authors.
Journal of Medicinal Chemistry | Year: 2011

The anthranilic acid diamides represent the most recent class of nonpeptide CCK 1 receptor (CCK 1-R) antagonists. Herein we describe the second phase of the anthranilic acid C-terminal optimization using nonproteinogenic amino acids containing a phenyl ring in their side chain. The Homo-Phe derivative 2 (VL-0797) enhanced 12-fold the affinity for the rat CCK 1-R affinity and 15-fold for the human CCK 1-R relative to the reference compound 12 (VL-0395). The eutomer of 2 (6) exhibited a nanomolar range affinity toward the human CCK 1-R and was at least 400-fold selective for the CCK 1-R over the CCK 2-R. Molecular docking in the modeled CCK 1-R and its validation by site-directed mutagenesis experiments showed that the 6 binding site overlaps that occupied by the C-terminal bioactive region of the natural agonist CCK. Owing to their interesting properties, new compounds provided by this study represent a solid basis for further advances aimed at synthesis of clinically valuable CCK 1-R antagonists. © 2011 American Chemical Society. Source

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