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News Article | November 22, 2016

CHICAGO, Nov. 22, 2016 /PRNewswire/ -- New Rhein Healthcare Investors LLC ("New Rhein"), an investment firm focused on healthcare therapeutics and medical devices, today announced it has successfully concluded its investment in Chase Pharmaceuticals through the sale of this portfolio...

Gatinel D.,Rothschild | Houbrechts Y.,University of Liège
Journal of Cataract and Refractive Surgery | Year: 2013

Purpose: To assess the differences in optical performance of 9 multifocal IOLs using the same optical bench and to propose a possible comparison for surgeons. Setting: Rothschild Foundation, Paris, France. Design: Experimental study. Methods: Nine IOLs (Acrysof Restor +3.0 diopter [D] SN6AD1, Acrysof Restor +4.0 D SN60D3, Acrysof aspheric monofocal SN60WF, Acri.Lisa 366D, Finevision Micro F, Tecnis ZM900, and Rezoom, Diffractiva Diff-s, and Lentis Mplus +3.0 D) were tested using the same optical bench that complies with International Organization for Standardization standard 11979 requirements. The through-focus modulation transfer functions (MTFs) were compared, and the image of the United States Air Force (USAF) target was taken while each IOL was at far, intermediate, and near focal points. Results: The through-focus MTF of the trifocal IOL showed a peak in the intermediate range that was not present with monofocal and bifocal IOLs. The USAF target images showed similar resolution with all IOLs for far focal points. Diffractive IOLs showed better resolution for near focal points, and the only sharp image in the intermediate range was obtained using the trifocal IOL. Conclusion: There was a significant difference in the degree of near, intermediate, and distance quality of the image with the various types of multifocal IOLs in vitro. Intermediate vision was more prominent with the trifocal IOL. Financial Disclosure: Dr. Gatinel has a proprietary interest in the optical frame used (Patent WO2011092169 [A1] 2011-08-04). Dr. Houbrechts has no financial or proprietary interest in any material or method mentioned. © 2013 ASCRS and ESCRS. Published by Elsevier Inc.

Gatinel D.,Rothschild
Investigative Ophthalmology and Visual Science | Year: 2012

Purpose. To investigate the application of anterior corneal and ocular aberrations in detecting mildly ectatic corneas. Methods. This study retrospectively reviewed the data of 220 eyes separated into three groups by the NIDEK Corneal Navigator System automated corneal classification software: normal (N) (n = 123); forme fruste keratoconus (N topography with contralateral KC) (n = 34); and KC (n = 63). Anterior corneal and ocular aberrations were obtained with the optical path difference scan and compared using a Kruskal-Wallis test. Evaluation of these data to discriminate between the three groups was assessed using a Receiver-Operating Characteristic curve analysis. Results. Corneal and ocular tilt, vertical coma, and trefoil were significantly different in the FFKC as compared with the N group. The discriminant functions between the FFKC and the N group, and between the KC and the N group reached an area under the receiver operating characteristic curve of 0.98 and 0, 96, respectively. Conclusion. Indices generated from corneal and ocular wavefront can identify very mild forms of ectasia that may be undetected by Placido-based neural network programs. © 2012 The Association for Research in Vision and Ophthalmology, Inc.

Touitou Y.,Rothschild
Journal of Physiology Paris | Year: 2013

Sleep is a key element, both physiologically and psychologically, in adolescent development. The prevalence of sleep disorders in western countries is important, as with age the sleep-wake cycle of adolescents becomes irregular and delayed in relation with later sleep onset and waking time resulting in rhythm desynchronization. A large number of adolescents sleep for 7-8. h instead of 9-10. h per night, which can lead to a cumulative sleep debt with fatigue, behavioral problems and poor academic achievement. The effect of electronic media use (such as television, mobile phone, computer, and electronic gaming) on sleep has been the object of several international studies, though pubertal changes may also impact adolescent sleep. Adolescents and their parents should be educated by professionals, including physicians and nurses, on the key role of sleep in adolescent well being and quality of life. A number of basic rules are proposed to improve sleep in adolescents. The permanent social jet lag experienced by a number of adolescents should be considered as a matter of public health. © 2013 Elsevier Ltd.

Persons who inject drugs (PWID) are at an elevated risk for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection. In many high-income countries, needle and syringe exchange programs (NSP) have been associated with reductions in blood-borne infections. However, we do not have a good understanding of the effectiveness of NSP in low/middle-income and transitional-economy countries. A systematic literature review based on PRISMA guidelines was utilized to collect primary study data on coverage of NSP programs and changes in HIV and HCV infection over time among PWID in low-and middle-income and transitional countries (LMICs). Included studies reported laboratory measures of either HIV or HCV and at least 50% coverage of the local injecting population (through direct use or through secondary exchange). We also included national reports on newly reported HIV cases for countries that had national level data for PWID in conjunction with NSP scale-up and implementation. Studies of 11 NSPs with high-coverage from Bangladesh, Brazil, China, Estonia, Iran, Lithuania, Taiwan, Thailand and Vietnam were included in the review. In five studies HIV prevalence decreased (range -3% to -15%) and in three studies HCV prevalence decreased (range -4.2% to -10.2%). In two studies HIV prevalence increased (range +5.6% to +14.8%). HCV incidence remained stable in one study. Of the four national reports of newly reported HIV cases, three reported decreases during NSP expansion, ranging from -30% to -93.3%, while one national report documented an increase in cases (+37.6%). Estimated incidence among new injectors decreased in three studies, with reductions ranging from -11/100 person years at risk to -16/100 person years at risk. While not fully consistent, the data generally support the effectiveness of NSP in reducing HIV and HCV infection in low/middle-income and transitional-economy countries. If high coverage is achieved, NSP appear to be as effective in LMICs as in high-income countries. Additional monitoring and evaluation research is needed for NSPs where reductions in HIV/HCV infection among PWID are not occurring in order to identify and correct contributing problems.

Ekmekcioglu C.,Medical University of Vienna | Touitou Y.,Rothschild
Obesity Reviews | Year: 2011

Overweight and obesity are the result of a chronic positive energy balance, and therefore the only effective therapies are a diet which, on the long term, provides lower calories than the daily expended energy and exercise. Because nearly every physiological and biochemical function of the body shows circadian variations it can be suggested that also different chronobiological aspects of food intake, like time of day, meal frequency and regularity, and also circadian desynchronizations like in shift work may affect energy metabolism and weight regulation. The aim of this review is therefore to summarize and discuss studies that have addressed these issues in the past and to also provide an overview about circadian variations of selected aspects of metabolism, gut physiology and also factors that may influence overall energy regulation. The results show that a chronic desynchronization of the circadian system like in shift work and also sleep deprivation can favour the development of obesity. Also, regarding energy balance, a higher meal frequency and regular eating pattern seem to be more advantageous than taking the meals irregularly and seldom. Additional studies are required to conclude whether time of day-dependent food intake significantly influences weight regulation in humans. © 2010 The Authors. obesity reviews © 2010 International Association for the Study of Obesity.

Devices, systems and methods for remotely entering, storing and sharing location addresses for a positional information device, e.g., a global positioning system (GPS) device, are provided. The present disclosure allows a user to easily and safely enter an address into a GPS device by giving that address to a remote communications link and to have that link automatically program the users GPS device for usage. The device, system and method of the present disclosure further allows the user to use this stored address(es) on multiple GPS devices without having to manually enter the address(es).

A digital imaging device and methods thereof that will enable the embedding and retrieving of information in digital images are provided. The digital imaging device includes a capture module for capturing an image and creating a digital image file; an input module for inputting information regarding the captured image; and a processing module for associating the inputted information to the digital image file. The device further includes a scanning module for reading a symbology associated with a printed digital image and wherein the processing module is adapted to use the symbology to retrieve the associated information of the digital image file. The device may be embodied as a digital camera, a mobile phone, personal digital assistant (PDA), etc.

A method and system for designing and affixing symbology, e.g., an identifier, into digital and printed images and using that symbology to link these images to a global computer network to allow the organization and processing of these images both while in digital form, and later when in printed form are provided. The method includes the steps of capturing an image with a digital image capture device and creating a digital image file; associating at least one identifier to the digital image file; and encoding the at least one identifier of the digital image file. The identifier includes a site location number (SLN), a customer identification number (CIN), a date the image was taken (DIT) and a picture sequence number (PSN). The identifier will be printed with the image and be used to retrieve the image at a later date and process user requests.

NEW YORK, Nov. 30, 2016 /PRNewswire/ -- Rothschild Global Advisory, part of the Rothschild & Co Group, is expanding its Debt Advisory business by appointing Michael Speller as Head of Debt Advisory, North America. Rothschild & Co's Financing Advisory business, which...

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