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Rostov-na-Donu, Russia

Rostov State Medical University is a Russia Government University of higher professional education and ministry on health and social medicine. Rostov State Medical University also known as Rostov State Medical Institute; RostSMU; RostGMU; Rostov State Government Medical University. Wikipedia.

Makarenko E.S.,Rostov State Medical University

Reflected high-intensity signals of left ventricular motion can be used for assessment of diastolic function of left ventricle. There are many correlations between reflected high-intensity signals, transmitral flow, and tissue Doppler imaging parameters. Diagnostic criteria of LV diastolic dysfunction based on measurement of LV motion are suggested. Source

Kogan M.I.,Rostov State Medical University | Zachoval R.,Charles University | Ozyurt C.,Ege University | Schafer T.,Ipsos Healthcare | Christensen N.,Ipsos Healthcare
Current Medical Research and Opinion

Objective: To estimate the prevalence of urinary incontinence (UI), overactive bladder (OAB), and other lower urinary tract symptoms (LUTS) in the Czech Republic, Russia, and Turkey. Methods: Stage one of this population-based survey consisted of computer-assisted telephone interviews to obtain prevalence estimates of storage, voiding, and post-micturition LUTS. Stage two face-to-face interviews evaluated subjects with mixed urinary incontinence (MUI), stress urinary incontinence (SUI) or OAB (case group) and a control group (subjects with other incontinence or LUTS complaints, or no symptoms). Outcome measure: Prevalence of LUTS categories were determined for each country based on International Continence Society (ICS) criteria. Results and limitations: A total of 3130 individuals agreed to participate in the survey, which found high rates of LUTS (men 80%; women 84%) and OAB (men 18%; women 28%). Duration of urinary symptoms was relatively brief (approximately 60% 3 years) and was associated with relatively modest effects on quality of life and work performance in the majority of individuals. Forty percent had consulted with a healthcare provider about their urinary symptoms, of whom 37% had consulted with a physician and 34% with an urologist, and 12% had been treated with a prescription medication. Drug therapy, while uncommon, was associated with a high degree of self-reported improvement (96%). Because of between-country population differences, aggregate results may not always be representative of results for each of the three countries individually. Study limitations include reliance on patient self-report, and potential bias introduced by patients who declined to participate in the survey. Conclusions: The results of this epidemiologic survey found high rates of LUTS and OAB, but low levels of medical consultation and very low use of medication treatment, despite high levels of improvement when medications were used. © 2014 Informa UK Ltd. Source

Demyanenko S.V.,Southern Federal University | Uzdensky A.B.,Southern Federal University | Sharifulina S.A.,Southern Federal University | Lapteva T.O.,Regional Consulting and Diagnostic Center | Polyakova L.P.,Rostov State Medical University
Biochimica et Biophysica Acta - General Subjects

Background Photodynamic therapy (PDT) is used for cancer treatment including brain tumors. But the role of epigenetic processes in photodynamic injury of normal brain tissue is unknown. Methods 5-Aminolevulinic acid (ALA), a precursor of protoporphyrin IX (PpIX), was used to photosensitize mouse cerebral cortex. PpIX accumulation in cortical tissue was measured spectrofluorometrically. Hematoxylin/eosin, gallocyanin-chromalum and immunohistochemical staining were used to study morphological changes in PDT-treated cerebral cortex. Proteomic antibody microarrays were used to evaluate expression of 112 proteins involved in epigenetic regulation. Results ALA administration induced 2.5-fold increase in the PpIX accumulation in the mouse brain cortex compared to untreated mice. Histological study demonstrated PDT-induced injury of some neurons and cortical vessels. ALA-PDT induced dimethylation of histone H3, upregulation of histone deacetylases HDAC-1 and HDAC-11, and DNA methylation-dependent protein Kaiso that suppressed transcriptional activity. Upregulation of HDAC-1 and H3K9me2 was confirmed immunohistochemically. Down-regulation of transcription factor FOXC2, PABP, and hBrm/hsnf2a negatively regulated transcription. Overexpression of phosphorylated histone H2AX indicated activation of DNA repair, but down-regulation of MTA1/MTA1L1 and PML - impairment of DNA repair. Overexpression of arginine methyltransferase PRMT5 correlated with up-regulation of transcription factor E2F4 and importin α5/7. Conclusion ALA-PDT injures and kills some but not all neurons and caused limited microvascular alterations in the mouse cerebral cortex. It alters expression of some proteins involved in epigenetic regulation of transcription, histone modification, DNA repair, nuclear protein import, and proliferation. General significance These data indicate epigenetic markers of photo-oxidative injury of normal brain tissue. © 2013 Elsevier B.V. Source

Chaplygina Y.V.,Rostov State Medical University
Morfologii{combining double inverted breve}a (Saint Petersburg, Russia)

The purpose of this study was to establish the regularities of the anatomical structure of the thyroid gland (TG) in healthy people aged 17-30 years of various somatic types, living in the Rostov region. The complex study of TG was carried out in 306 healthy subjects (150 male and 156 female) with ultrasonography performed according to C. L. Brown (1981). Somatotyping was done using the technique of R. N. Dorokhov and V. G. Petrukhina (1989). Sexual dimorphism of the linear dimensions, right and left lobe volumes and of TG total volume was demonstrated. In men,TG total volume was significantly greater (P<0.05), than that in women (11.7 +/- 0.43 and 9.37 +/- 0.28 cm3, respectively). Regional and constitutional features of the thyroid gland in healthy subjects living in the Rostov region were established. Linear dimensions, total TG volume and the volumes of TG lobes were found to be lower in the residents of the Rostov region as compared to these parameters in people living in the northern regions of Russia. Source

Soldatkin V.A.,Rostov State Medical University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova

An open non-randomized controlled prospective study was conducted to investigate the efficacy and safety of valdoxan in the treatment of depression as monotherapy and in the combination with other drugs. Based on the clinical and psychometric measures, author confirmed the high efficacy of valdoxan. The drug can be combined with other antidepressants, no adverse effects are observed in these cases. Positive changes in sleep patterns during the treatment with valdoxan were found. The high tolerability and minimal risk of serious adverse effects were observed. Preliminary data revealed that the age of the patient and scores on some HAMD items were predictors of treatment efficacy. The authors developed a computer program for expressassessment of probability of remission and response to treatment. Source

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