Rostov-na-Donu, Russia
Rostov-na-Donu, Russia

Rostov State Medical University is a Russia Government University of higher professional education and ministry on health and social medicine. Rostov State Medical University also known as Rostov State Medical Institute; RostSMU; RostGMU; Rostov State Government Medical University. Wikipedia.


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Ermakova L.A.,Rostov Scientific Research Institute of Microbiology and Parasitology | Nagorny S.A.,Rostov Scientific Research Institute of Microbiology and Parasitology | Krivorotova E.Y.,Rostov Scientific Research Institute of Microbiology and Parasitology | Pshenichnaya N.Y.,Rostov State Medical University
International Journal of Infectious Diseases | Year: 2014

Background: Dirofilariasis is an emerging zoonotic infection in which the human serves as an accidental host. Russia has been one of the most important endemic regions worldwide for Dirofilaria repens, the most prevalent Dirofilaria species in Europe. Methods: Based on a cohort of patients at the Rostov Medical University, we provide an epidemiological description of 236 human cases, reporting common clinical symptoms and treatment options for D. repens infections in humans. The performance of a non-commercial immunoassay was validated in a diagnostic sub-study (diagnostic accuracy 83%). Data from mosquito surveys and cross-sectional surveys of dogs, the main reservoir of D. repens, are also presented. Results: Results showed important variations in prevalence depending on sex, geographic location, and the use of dogs (professional service dogs or pets). Conclusions: The particularly high prevalence of Dirofilaria infection in professional dogs used in the police force and armed forces poses a particular problem, since these dogs may serve as epidemiologically important amplifiers within the region of the former Soviet Union. © 2014 The Authors.


Pshenichnaya N.Y.,Rostov State Medical University | Sydenko I.S.,Central District Hospital of Salsk District of the Rostov Region | Klinovaya E.P.,Central District Hospital of Salsk District of the Rostov Region | Romanova E.B.,Rostov State Medical University | Zhuravlev A.S.,First Moscow Medical University Im Sechenov
International Journal of Infectious Diseases | Year: 2016

Three cases of family transmission of laboratory-confirmed Crimean-Congo hemorrhagic fever (CCHF) among spouses are reported. These spouses had sexual contact at the end of the incubation period or during the early stage of the mild form of CCHF, without any hemorrhagic symptoms in the first infected spouse. This report demonstrates that sexual contact may represent a real risk of CCHF transmission, even if the patient only experiences mild symptoms. © 2016 The Authors.


Kogan M.I.,Rostov State Medical University | Zachoval R.,Charles University | Ozyurt C.,Ege University | Schafer T.,Ipsos Healthcare | Christensen N.,Ipsos Healthcare
Current Medical Research and Opinion | Year: 2014

Objective: To estimate the prevalence of urinary incontinence (UI), overactive bladder (OAB), and other lower urinary tract symptoms (LUTS) in the Czech Republic, Russia, and Turkey. Methods: Stage one of this population-based survey consisted of computer-assisted telephone interviews to obtain prevalence estimates of storage, voiding, and post-micturition LUTS. Stage two face-to-face interviews evaluated subjects with mixed urinary incontinence (MUI), stress urinary incontinence (SUI) or OAB (case group) and a control group (subjects with other incontinence or LUTS complaints, or no symptoms). Outcome measure: Prevalence of LUTS categories were determined for each country based on International Continence Society (ICS) criteria. Results and limitations: A total of 3130 individuals agreed to participate in the survey, which found high rates of LUTS (men 80%; women 84%) and OAB (men 18%; women 28%). Duration of urinary symptoms was relatively brief (approximately 60% 3 years) and was associated with relatively modest effects on quality of life and work performance in the majority of individuals. Forty percent had consulted with a healthcare provider about their urinary symptoms, of whom 37% had consulted with a physician and 34% with an urologist, and 12% had been treated with a prescription medication. Drug therapy, while uncommon, was associated with a high degree of self-reported improvement (96%). Because of between-country population differences, aggregate results may not always be representative of results for each of the three countries individually. Study limitations include reliance on patient self-report, and potential bias introduced by patients who declined to participate in the survey. Conclusions: The results of this epidemiologic survey found high rates of LUTS and OAB, but low levels of medical consultation and very low use of medication treatment, despite high levels of improvement when medications were used. © 2014 Informa UK Ltd.


Demyanenko S.V.,Southern Federal University | Uzdensky A.B.,Southern Federal University | Sharifulina S.A.,Southern Federal University | Lapteva T.O.,Regional Consulting and Diagnostic Center | Polyakova L.P.,Rostov State Medical University
Biochimica et Biophysica Acta - General Subjects | Year: 2014

Background Photodynamic therapy (PDT) is used for cancer treatment including brain tumors. But the role of epigenetic processes in photodynamic injury of normal brain tissue is unknown. Methods 5-Aminolevulinic acid (ALA), a precursor of protoporphyrin IX (PpIX), was used to photosensitize mouse cerebral cortex. PpIX accumulation in cortical tissue was measured spectrofluorometrically. Hematoxylin/eosin, gallocyanin-chromalum and immunohistochemical staining were used to study morphological changes in PDT-treated cerebral cortex. Proteomic antibody microarrays were used to evaluate expression of 112 proteins involved in epigenetic regulation. Results ALA administration induced 2.5-fold increase in the PpIX accumulation in the mouse brain cortex compared to untreated mice. Histological study demonstrated PDT-induced injury of some neurons and cortical vessels. ALA-PDT induced dimethylation of histone H3, upregulation of histone deacetylases HDAC-1 and HDAC-11, and DNA methylation-dependent protein Kaiso that suppressed transcriptional activity. Upregulation of HDAC-1 and H3K9me2 was confirmed immunohistochemically. Down-regulation of transcription factor FOXC2, PABP, and hBrm/hsnf2a negatively regulated transcription. Overexpression of phosphorylated histone H2AX indicated activation of DNA repair, but down-regulation of MTA1/MTA1L1 and PML - impairment of DNA repair. Overexpression of arginine methyltransferase PRMT5 correlated with up-regulation of transcription factor E2F4 and importin α5/7. Conclusion ALA-PDT injures and kills some but not all neurons and caused limited microvascular alterations in the mouse cerebral cortex. It alters expression of some proteins involved in epigenetic regulation of transcription, histone modification, DNA repair, nuclear protein import, and proliferation. General significance These data indicate epigenetic markers of photo-oxidative injury of normal brain tissue. © 2013 Elsevier B.V.


Makarenko E.S.,Rostov State Medical University
Kardiologiya | Year: 2013

Reflected high-intensity signals of left ventricular motion can be used for assessment of diastolic function of left ventricle. There are many correlations between reflected high-intensity signals, transmitral flow, and tissue Doppler imaging parameters. Diagnostic criteria of LV diastolic dysfunction based on measurement of LV motion are suggested.


Chaplygina Y.V.,Rostov State Medical University
Morfologii{combining double inverted breve}a (Saint Petersburg, Russia) | Year: 2013

The purpose of this study was to establish the regularities of the anatomical structure of the thyroid gland (TG) in healthy people aged 17-30 years of various somatic types, living in the Rostov region. The complex study of TG was carried out in 306 healthy subjects (150 male and 156 female) with ultrasonography performed according to C. L. Brown (1981). Somatotyping was done using the technique of R. N. Dorokhov and V. G. Petrukhina (1989). Sexual dimorphism of the linear dimensions, right and left lobe volumes and of TG total volume was demonstrated. In men,TG total volume was significantly greater (P<0.05), than that in women (11.7 +/- 0.43 and 9.37 +/- 0.28 cm3, respectively). Regional and constitutional features of the thyroid gland in healthy subjects living in the Rostov region were established. Linear dimensions, total TG volume and the volumes of TG lobes were found to be lower in the residents of the Rostov region as compared to these parameters in people living in the northern regions of Russia.


Soldatkin V.A.,Rostov State Medical University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

An open non-randomized controlled prospective study was conducted to investigate the efficacy and safety of valdoxan in the treatment of depression as monotherapy and in the combination with other drugs. Based on the clinical and psychometric measures, author confirmed the high efficacy of valdoxan. The drug can be combined with other antidepressants, no adverse effects are observed in these cases. Positive changes in sleep patterns during the treatment with valdoxan were found. The high tolerability and minimal risk of serious adverse effects were observed. Preliminary data revealed that the age of the patient and scores on some HAMD items were predictors of treatment efficacy. The authors developed a computer program for expressassessment of probability of remission and response to treatment.


Batyushin M.M.,Rostov State Medical University
Russian Journal of Cardiology | Year: 2015

Aim. To evaluate prognostic significance of TSTST in cardiovascular complications development. Material and methods. Totally 162 persons studied, of those 67 with arterial hypertension (AH) and 95 their close relatives of the 1 grade of relativity, healthy at the moment of the first examination in 1998. Second study of the group has been done in 16 years, in 2014. Totally 28 families studied. In 16 years, 101 person had arterial hypertension, and in 34 it had been developed during the observation period. Ischemic heart disease (IHD) was diagnosed in 38 patients, diabetes (DM) — in 21 (all had 2nd type). For 16 years, the brain stroke (BS) developed in 15 participants, in 6 cases it was fatal, and myocardial infarction (MI) — in 13 participants, in 10 cases fatal. Totally 15 patients died (9,3%), one — from melanoma. The participants at the baseline were studied for the TSTST by Henkin R. J. method under Konstantinov E. N. modification. For the second study in 16 years a protocol was created included the results of anthropometric and hemodynamic data, and the cases of AH, IHD, MI and BS, and the death. Results. In the group of those died comparing to the others, were higher levels of TSTST at the baseline (2,52±0,39 vs 1,38±0,16, p<0,05). During 16 years among 54 participants with high TSTST (more than 0,64) died 14 — 25,9%, and from 47 participants with normal TSTST died 1 — 2,13%. In analysis of the influence of TSTST on cardiovascular outcomes, it was shown that the risk of fatal and nonfatal cases of BS increased with TSTST, but the risk of MI did not differ significantly. In addition, the survival of the patients was significantly lower in the case of higher TSTST in BS, as in MI. In survival analysis for the influence of TSTST on nonfatal cases of MI and BS there were no such influence. Conclusion. High TSTST in AH patients increases the risk of fatal and nonfatal cases of BS, fatal MI during 16 years of study. High TSTST is followed by the increase of the risk of new onset of AH, and higher mean values of BP in AH. The decrease of general survival and 16-year survival of AH patients due to fatal cases of BS and MI is caused by higher TSTST. © 2015, Silicea-Poligraf. All rights reserved.


Lebedenko A.A.,Rostov State Medical University | Semernik O.E.,Rostov State Medical University
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2015

Background: Asthma is one of the urgent problems of modern pediatrics, but neuroregulation mechanisms underlying this disease have not been fully disclosed so far. The autonomic interactions assessment in patients with bronchial asthma is important to understand the pathogenesis and prognosis of the disease. Objective: The aim of the study was to investigate features of autonomic response in children with asthma in the period of exacerbation. Methods: The autonomic nervous system (ANS) of 82 children aged 6 to 18 years old with asthma in the period of exacerbation were investigated. The spectral analysis of the heart rate variability and the correlation rhythmography method (skaterography) were used to assess the ANS state. Investigations were carried out at rest and after clinoorthostatic test. Results: Non-respiratory (slow) waves reflecting the degree of activity of humoral and neural canals of heart rate central regulation were dominated at the spectrogram of 72 (87.80%) children experiencing asthma attack; more than half of patients (58.53%) had predominantly very low-frequency component (VLF%) in the range of fluctuation rate that indicated the influence of neurohumoral regulation. A significant increase in vagosympathetic balance coefficient (LF /HF) was recorded after clinoorthostatic test indicating the activation of the sympathetic nervous system. According to the correlation rhythmography data, a considerable scattering of scattergram points was detected in patients in the baseline state that indicated the predominant influence of parasympathetic nervous system. After the clinoorthostatic test, on the contrary, we observed the 蠐tightness蠑 of the scattergram cloud that could indicate sympathicotonia. Conclusion: The imbalance of the autonomic nervous system in the form of activation of the sympathetic and neurohumoral regulation department was found in children with asthma.


Mikashinovich Z.I.,Rostov State Medical University | Belousova E.S.,Rostov State Medical University
Bulletin of Experimental Biology and Medicine | Year: 2016

Long-term administration of simvastatin to rats, irrespective of the baseline cholesterol levels, induced biochemical changes in erythrocytes attesting to hypoxic damage (accumulation of lactate and 2,3-diphosphoglycerate), disturbances in ATP-dependent mechanisms of ion homeostasis regulation (decrease in total ATPase and Ca2+-ATPase activities), and antioxidant enzymes system imbalance. These changes can be considered as a sensitive indicator and molecular basis of cell damage during long-term administration of statins. © 2016 Springer Science+Business Media New York

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