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Kit O.I.,Rostov Research Institute of Oncology of the Ministry of Healthcare of the Russian Federation | Vodolazhsky D.I.,Rostov Research Institute of Oncology of the Ministry of Healthcare of the Russian Federation
Molecular Biology | Year: 2015

The review summarizes current data on the molecular genetic mechanisms underlying the pathogenesis of colorectal cancer (CRC) and addresses the connections between these mechanisms and biomarkers used for predictive diagnosis, risk stratification, prognosis, and predicting response to chemotherapy and tar-geted therapy. Evidence of microRNA involvement in the regulation of major signaling pathways affected by CRC pathogenesis is discussed, and signaling pathways that can be used as targets in the therapy of colorectal cancer are examined. © 2015, Pleiades Publishing, Inc. Source


Kit O.I.,Rostov Research Institute of Oncology of the Ministry of Healthcare of the Russian Federation | Vodolazhsky D.I.,Rostov Research Institute of Oncology of the Ministry of Healthcare of the Russian Federation | Kutilin D.S.,Rostov Research Institute of Oncology of the Ministry of Healthcare of the Russian Federation | Gudueva E.N.,Rostov Research Institute of Oncology of the Ministry of Healthcare of the Russian Federation
Molecular Biology | Year: 2015

It is assumed that changes in the number of copies that belong to the basic mechanisms that control the expression of genes are important for malignization. Therefore, the characterization of these genes and the precise assessment of the number of copies are important for understanding the molecular basis of tumor emergence and progression in the human organism, as well as for the identification of predictive markers of malignization. In the present study, the relative number of copies of 19 loci (BAX, GSTP1, CASP3, CASP8, HIF1A, OCT4, C-MYC, SOX2, BCL2, CASP8/FADD, NANOG, P53, CASP9, IL-10, NFKB1, HV2, and ACTB) in cancerous and conventionally healthy tissues from 25 residents of southern Russia with a histologically confirmed diagnosis of adenocarcinoma (stages G1–G2 and G3) or signet cell gastric cancer were determined by quantitative real-time PCR. Changes in the number of copies of the gene were shown to be specific to particular histological types of cancer, as well as to depend on the stage of tumor cell differentiation. The data suggest that the number of copies of changes in the BAX, CASP3, CASP8, OCT4, C-MYC, SOX2, BCL2, NANOG, CASP9, NFKB1, HV2, ACTB, MKI67, IL-10, GSTP1, and P53 genes play an important role in the malignization of gastric tissue. © 2015, Pleiades Publishing, Inc. Source

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