Rostov Research Oncological Institute

Rostov-na-Donu, Russia

Rostov Research Oncological Institute

Rostov-na-Donu, Russia

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Kit O.I.,Rostov Research Oncological Institute | Zlatnik E.Yu.,Rostov Research Oncological Institute | Peredreyeva L.V.,Rostov Research Oncological Institute
Bulletin of Experimental Biology and Medicine | Year: 2014

The effects of zinc and metal alloy (Cu, Zn, and Fe) nanoparticles on transplantation capacity of tumors (mouse sarcoma 37, rat sarcoma 45 and Pliss lymphosarcoma) and the levels of exogenous Zn in tumor and non-tumor tissues of mice were studied. Preincubation (30 min, 37 C) of sarcoma 37 cells with zinc nanoparticles and sarcoma 45 with alloy nanoparticles before transplantation completely prevented the tumor development in animals. Preincubation of Pliss lymphosarcoma cells with nanoparticles led to tumor growth inhibition and prolongation of the animal lifespan. The effect of metal nanoparticles was presumably explained by their local destructive effect on tumor cells. Zinc nanoparticles injected into the tumor concentrated in it after 4 days and were not detected in the adjacent normal tissue. Selective accumulation of metal nanoparticles in tumor tissue and their antiproliferative effect suggested their use as antitumor drugs. © 2014 Springer Science+Business Media New York.


Kit O.I.,Rostov Research Oncological Institute | Zlatnik E.Yu.,Rostov Research Oncological Institute | Peredreyeva L.V.,Rostov Research Oncological Institute | Chervonobrodov S.P.,Carbonlight Company
Bulletin of Experimental Biology and Medicine | Year: 2014

The effects of short single-walled carbon nanotubules functionalized by COOH- and NH2- containing groups (NT-COOH and NT-NH2), on the dynamics of transplanted Pliss lymphosarcoma growth were studied after tumor cell preincubation with nanotubules and after injection of nanotubules into the developing tumor. Tumor growth was inhibited and the lifespan of rats with tumors was prolonged by 1.7 times after transplantation of tumor preincubated with NT-NH2, while NT-COOH caused no effect of this kind. Intratumor injection of NT-NH2 inhibited tumor growth over 3 weeks and prolonged animal lifespan. © 2014 Springer Science+Business Media New York.


PubMed | Rostov Research Oncological Institute
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2014

The effects of short single-walled carbon nanotubules functionalized by COOH- and NH2- containing groups (NT-COOH and NT-NH2), on the dynamics of transplanted Pliss lymphosarcoma growth were studied after tumor cell preincubation with nanotubules and after injection of nanotubules into the developing tumor. Tumor growth was inhibited and the lifespan of rats with tumors was prolonged by 1.7 times after transplantation of tumor preincubated with NT-NH2, while NT-COOH caused no effect of this kind. Intratumor injection of NT-NH2 inhibited tumor growth over 3 weeks and prolonged animal lifespan.


PubMed | Rostov Research Oncological Institute
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2014

The effects of zinc and metal alloy (Cu, Zn, and Fe) nanoparticles on transplantation capacity of tumors (mouse sarcoma 37, rat sarcoma 45 and Pliss lymphosarcoma) and the levels of exogenous Zn in tumor and non-tumor tissues of mice were studied. Preincubation (30 min, 37C) of sarcoma 37 cells with zinc nanoparticles and sarcoma 45 with alloy nanoparticles before transplantation completely prevented the tumor development in animals. Preincubation of Pliss lymphosarcoma cells with nanoparticles led to tumor growth inhibition and prolongation of the animal lifespan. The effect of metal nanoparticles was presumably explained by their local destructive effect on tumor cells. Zinc nanoparticles injected into the tumor concentrated in it after 4 days and were not detected in the adjacent normal tissue. Selective accumulation of metal nanoparticles in tumor tissue and their antiproliferative effect suggested their use as antitumor drugs.


PubMed | Rostov Research Oncological Institute
Type: Journal Article | Journal: Biomeditsinskaia khimiia | Year: 2016

According to modern concepts cancer is a complex dynamic system having multiple relationships with both the immediate environment and with remote nonmalignant tissues and organs. Changes in the redox balance in them can result in disruption of the normal tissue control. Understanding of the biology of redox processes in a particular tumor and its surroundings, and of their functioning mechanisms is necessary for the development of new anti-cancer strategies based on the effects on the redox state of the tumor and surrounding tissue. Thus the aim of this work was to investigate activity of enzymatic systems influencing the redox state in the tumor tissue, peritumoral area and nonmalignant tissue (taken along the line of resection) for different histological types of tumors. The data obtained showed a similar level of reduced glutathione (GSH) in tumor tissues of gastric adenocarcinoma and vulvar squamous cell carcinoma, but its dynamics in the tissues surrounding the tumor was different. In contrast to the gastric adenocarcinoma the carcinoma of the vulva had a significant level of GSH and higher activity of glutathione dependent enzymes in the tumor tissue and its peritumoral area compared with the surrounding nonmalignant tissue. The results indicate that there are differences in the functioning of the redox regulatory systems in the tumor tissue and its surrounding tissues of various histological origin and localization, possibly due to different mechanisms involved in maintenance of the redox balance in the originally nonmalignant tissue.

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