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Sidorenko Y.S.,Russian Academy of Sciences | Bbalyazin-Parfyonov I.V.,Rostov on Don Scientific Research Oncological Institute | Frantsiyants E.M.,Rostov on Don Scientific Research Oncological Institute | Komarova E.F.,Rostov on Don Scientific Research Oncological Institute | And 2 more authors.
Sovremennye Tehnologii v Medicine | Year: 2011

The aim of the investigation is to study the dynamics of some activity indexes of lipid peroxidation in the tissue of primary cerebral tumours and brain metastases tumours for the purpose of treatment optimization. Materials and Methods. There have been studied tumour tissue samples (anaplastic gliomas and benign astrocytomas) and their perifocal areas taken from the patients during the oncotomy operations and the surgeries on brain metastases tissues excision (breast cancer, lung cancer, renal cell carcinoma, skin melanoma). Results. Primary malignancies and brain cancer metastases of various localization have been stated to have common biochemical mechanisms. There has been noticed the more aggressive "metabolic" nature of brain cancer metastases of various localization compared to malignant gliomas. The metastases near hypothalamus as well as multiple metastases have been revealed to be of more aggressive nature. Source


Kit O.I.,Rostov on Don Scientific Research Oncological Institute | Sidorenko Y.S.,Rostov on Don Scientific Research Oncological Institute | Balyazin-Parfyonov I.V.,Rostov on Don Scientific Research Oncological Institute | Frantsiyants E.M.,Rostov on Don Scientific Research Oncological Institute | And 4 more authors.
Sovremennye Tehnologii v Medicine | Year: 2011

The objective of the investigation is to study the survival rate of patients with malignant gliomas using adjuvant chemotherapy on autologous media using melatonin. Materials and methods. There has been studied a number of clinical factors in 291 patients with malignant cerebral gliomas who underwent complex therapy. The patients of the main group were divided into three subgroups according to treatment type: an operation and autohemochemotherapy, an operation and autohemochemotherapy with melatonin (Melaxen), and intraarterial chemotherapy with Melaxen. Results. The analysis of general and uneventful survival rate according to Kaplan-Mayer over the more than 5 years' period in all the patients under study has showed that general survival rate was higher in patients with adjuvant chemotherapy on automedia supported by Melaxen. Source

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