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Roskilde, Denmark

Roskilde University is a Danish public university founded in 1972 and located in Trekroner in the Eastern part of Roskilde. The university awards bachelor, master's degrees and Ph.D. degrees in a wide variety of subjects. Wikipedia.

Yamanaka N.,University of Minnesota | Rewitz K.F.,Roskilde University | O'Connor M.B.,University of Minnesota
Annual Review of Entomology | Year: 2013

The steroid hormone ecdysone is the central regulator of insect developmental transitions. Recent new advances in our understanding of ecdysone action have relied heavily on the application of Drosophila melanogaster molecular genetic tools to study insect metamorphosis. In this review, we focus on three major aspects of Drosophila ecdysone biology: (a) factors that regulate the timing of ecdysone release, (b) molecular basis of stage-and tissue-specific responses to ecdysone, and (c) feedback regulation and coordination of ecdysone signaling. © 2013 by Annual Reviews. All rights reserved. Source

Dyre J.C.,Roskilde University
Journal of Physical Chemistry B | Year: 2014

Recent developments show that many liquids and solids have an approximate "hidden" scale invariance that implies the existence of lines in the thermodynamic phase diagram, so-called isomorphs, along which structure and dynamics in properly reduced units are invariant to a good approximation. This means that the phase diagram becomes effectively one-dimensional with regard to several physical properties. Liquids and solids with isomorphs include most or all van der Waals bonded systems and metals, as well as weakly ionic or dipolar systems. On the other hand, systems with directional bonding (hydrogen bonds or covalent bonds) or strong Coulomb forces generally do not exhibit hidden scale invariance. The article reviews the theory behind this picture of condensed matter and the evidence for it coming from computer simulations and experiments. © 2014 American Chemical Society. Source

Christensen T.B.,Roskilde University
Journal of Cleaner Production | Year: 2011

The article explores the integration of alternative drivetrain solutions in the automotive industry. The article includes an analysis of the structure of the conventional automotive value chain and presents four examples of alternative vehicle designs. The article concludes that the component sharing across drivetrain solutions such as the battery electric, the hybrid and the fuel cell system opens a window of opportunity for modular design strategies that may make integration into the otherwise locked conventional production system possible. © 2010 Elsevier Ltd. All rights reserved. Source

Widlund A.L.,Roskilde University
Expert reviews in molecular medicine | Year: 2013

Resveratrol (RSV) is a natural polyphenol produced by plants and is proposed to have multiple beneficial effects on health. In recent years, the interest in this molecule has increased nearly exponentially following the major findings that RSV (I) is chemo-preventive in some cancer models, (II) is cardio-protective and (III) has positive effects on metabolism in mammals and increases lifespan in lower organisms. Mechanistic target of rapamycin (mTOR) is a central controller of cell growth, proliferation, metabolism and angiogenesis. As a part of the mTORC1 and mTORC2 complexes, the mTOR kinase plays a key role in several pathways involved in cancer and metabolic diseases. Recent studies suggest that modulation of the mTOR signalling pathway could play an important role in mediating the beneficial effects of RSV. Therefore, this review summarises the current findings regarding RSV and its inhibition/activation of the proteins in the mTOR pathway, and thereby propose the proteins of the mTOR cascade to be primary targets for RSV. RSV affects many different targets related to mTOR, and it is not clear which is most relevant. However, most frequently, RSV is found to inhibit the activity of the mTOR pathway proteins, and to activate AMPK and LKB1, which can suppress mTOR signalling. Thus, it appears that RSV plays a role in modulation of proteins of the mTOR pathway although more research is still needed to fully understand the interaction. Source

Dyre J.C.,Roskilde University
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | Year: 2013

The last half-century of research into the structure, dynamics, and thermodynamics of simple liquids has revealed a number of approximate universalities. This paper argues that simple liquids' reduced-coordinate constant-potential-energy hypersurfaces constitute a quasiuniversal family of compact Riemannian manifolds parametrized by a single number; from this follows the quasiuniversalities. © 2013 American Physical Society. Source

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