Time filter

Source Type

Arakelyan M.S.,L A Vorokhobov City Clinical Hospital No 67 | Poteshkina N.G.,rogov Russian Research Medical University | Mogutova P.A.,rogov Russian Research Medical University
Russian Journal of Cardiology | Year: 2012

Aim. To identify the most important risk factors of recurrent atrial fibrillation (AF) and their prognostic value in patients with arterial hypertension (AH). Material and methods. In total, the study included 60 patients with Stage 1–3 AH (Grade I–III, cardiovascular risk 2–4): 20 with the first episode of AF (33%) and 40 with recurrent AF (67%). In all patients, sinus rhythm was restored with pharmacological or electric impulse therapy. At baseline and 6 months after restoring sinus rhythm, the assessment of medical history, antihypertensive and antiarrhythmic therapy, echocardiography, and Doppler ultrasound were performed. To identify silent cardiac arrhythmias and conductivity disorders, Holter electrocardiography monitoring was performed; coronary heart disease was verified with the bicycle stress test. Statistical analyses were performed using the Statistica 6.0 software. Results. The early recurrence of AF was associated with Stage 3 AH, AF in anamnesis, and left atrium dilatation. Conclusion. The combination of Stage 3 AH, AF in anamnesis, and left atrium dilatation was associated with a higher risk of recurrent AF, compared to each of these factors in isolation. © 2012, Silicea-Poligraf. All rights reserved.


Mikhal'chik E.V.,Federal Medical and Biological Agency of the Russian Federation | Suprun M.V.,Federal Medical and Biological Agency of the Russian Federation | Fedorkova M.V.,Federal Medical and Biological Agency of the Russian Federation | Ibragimova G.A.,Federal Medical and Biological Agency of the Russian Federation | And 3 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2014

The content of ATP in scalp hair bulbs in humans was measured in the hair roots from 15 healthy volunteers. Light and electron microscopy confirmed the presence of outer and an inner root sheaths in the root of pulled out anagen hair. Incubation of samples in buffer solution led to extraction of ATP, which was measured by the chemiluminescent method. Mechanic disintegration of hair bulbs and their freezing-defrosting did not increase ATP output. The results of microscopy indicated that ATP extraction procedure was associated with separation of the outer radical sheath from the inner one without impairing the structure of the inner sheath. The mean content of ATP was 12±2 pmol per bulb. The use of pulled out hair bulbs for ATP measurements simplified the procedure as involved no surgical removal of follicles. © 2014 Springer Science+Business Media.


Ussov W.Y.,Research Institute of Cardiology | Belyanin M.L.,Research Institute of Cardiology | Bezlepkin A.I.,Research Institute of Cardiology | Borodin O.Y.,Research Institute of Cardiology | And 2 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2016

Experimental study of a new paramagnetic complex Mn-DCTA is carried out. The complex (0.5 M manganese(II) solution with trans-1,2-diamine cyclohexane-N,N,N’,N’-tetraacetic acid; Cyclomang) was used for contrast magnetic resonance imaging visualization of CNS involvement in dogs with severe forms of Babesia canis infection. CNS injuries were visualized in all cases, with highly intense contrasting at the expense of Mn-DCTA accumulation at the periphery of the damaged zone. Quantitative evaluation of the paramagnetic accumulation in the focus showed that the amplification index wa s 1.19±0.11 for the central areas and 1.47±0.17 for the peripheral ones. The pituitary (1.18±0.05) and vascular plexuses of the lateral ventricles (1.12±0.09) were also contrasted. Injection of the paramagnetic to dogs was not associated with any kinds of pathological or physiological reactions. Mn-DCTA complex allowed contrast visualization of the focal injuries to the CNS and could be regarded as a paramagnetic contrast agent for magnetic resonance imaging of brain injuries in dogs. © 2016 Springer Science+Business Media New York


Bart B.Y.,rogov Russian Research Medical University | Dergunova E.N.,rogov Russian Research Medical University | Vartanyan E.A.,rogov Russian Research Medical University | Kulbachinskaya O.M.,rogov Russian Research Medical University
Russian Journal of Cardiology | Year: 2012

Aim. To study right ventricular (RV) structure and function, as well as cardiac and pulmonary hemodynamic parameters, in patients with chronic obstructive pulmonary disease (COPD) of moderate severity. Material and methods. The study included 37 COPD patients and 20 healthy controls. All participants underwent echocardiography (EchoCG) and the assessment of lung function (LF). Results. COPD patients demonstrated an early increase in anterior RV wall thickness and RV chamber volume, already at the stage of moderate elevation in pulmonary artery systolic pressure. Pre-capillary hemodynamic variant of pulmonary hypertension was characterised by a significant increase in pulmonary vascular resistance (р<0,001) and normokinetic hemodynamic type in patients with a longer COPD duration. Conclusion. Disturbed relaxation of RV longitudinal fibres is the initial pathological change, followed by global RV dysfunction and disturbed transverse RV contractility. These markers, which precede RV ejection fraction reduction, could be regarded as early criteria of latent systolic dysfunction in patients with a longer duration of moderately severe COPD.


Alimova E.E.,rogov Russian Research Medical University | Leonova M.V.,rogov Russian Research Medical University | Belousov Y.,rogov Russian Research Medical University
Russian Journal of Cardiology | Year: 2012

Aim. To investigate the effects of various antihypertensive combinations on metabolic parameters in patients with arterial hypertension (AH). Material and methods. The study included 144 AH patients and 7 groups of combination therapy: Group 1 (n=30) – trandolapril/verapamil SR; Group 2 (n=19) – perindopril/indapamide; Group 3 (n=15) – felodipine/metoprolol; Group 4 (n=20) – amlodipine/atenolol; Group 5 (n=20) – ACE inhibitor/hydrochlorothiazide (HCT); Group 6 (n=22) – telmisartan/lacidipine; and Group 7 (n=18) – metoprolol/HCT. In all participants, the parameters of lipid, carbohydrate, and purine metabolism were assessed. The effects of antihypertensive combinations on the risk of metabolic disturbances were studied using the factor regression analysis of quantitative and qualitative parameters (factors) as weighted ordered functions. Results. The negative effects on the levels of cholesterol (CH), triglycerides (TG), and glucose were most pronounced for the combination of metoprolol and HCT, while the combination of amlodipine and atenolol demonstrated the weakest negative effects on CH and glucose levels. The levels of CH, TG, and uric acid were affected to the least extent by the combination therapy with ACE inhibitor and HCT, which was also associated with a reduction in glucose levels. The combination of trandolapril and verapamil SR had the largest positive effect on the levels of CH, TG, and uric acid, together with a beneficial effect on glucose levels. The combination therapy with perindopril and indapamide was the most beneficial for the levels of CH and TG, while the felodipine/metoprolol combination had the most pronounced positive effects on TC and glucose levels. The combination of lacidipine and telmisartan was the most beneficial for glucose levels, but negatively affected the levels of uric acid. The perindopril/indapamide combination demonstrated negative effects on glucose levels. The full doses of diuretics and β-blockers negatively affected the levels of TC and glucose, while the full doses of ACE inhibitors benefited these metabolic parameters. Conclusion. The combination of a β-blocker and HCT was the least desirable, in terms of metabolic safety, for the treatment of AH patients. Including ACE inhibitors in the combination therapy demonstrated beneficial metabolic effects. To minimise the pre-existing metabolic disturbances and prevent the negative metabolic effects of diuretics, full doses of ACE inhibitors are required. © 2012, Silicea-Poligraf. All rights reserved.


Poteshkina N.G.,rogov Russian Research Medical University
Russian Journal of Cardiology | Year: 2012

The review discusses the clinical impact of salt consumption on the cardiovascular system status. The therapeutic potential of reduced salt intake, in order to facilitate regression of cardiovascular disturbances, is also discussed. Daily consumption of standard or increased amounts of salt results in the complex multilevel changes of cardiac chambers, arterial and venous vessels, and microcirculation in individuals with normal and elevated blood pressure (BP). The underlying mechanisms, both hemodynamic and non-hemodynamic, are present even in normotensive people. Reduced salt consumption is associated with the regression of structural cardiovascular disturbances. © 2012, Silicea-Poligraf. All rights reserved.


Shaidyuk O.Y.,rogov Russian Research Medical University
Russian Journal of Cardiology | Year: 2012

Aim. The sleep apnoea syndrome (SAS) is a widely prevalent but under-studied condition which might aggravate the clinical course of various diseases. This study aimed to assess the influence of SAS on the clinical course of coronary heart disease (CHD) and quality of life (QoL) of CHD patients. Material and methods. The study included 186 patients with various CHD forms and 24 controls with angiographically confirmed absence of CHD. The patients were divided into groups of effort angina, post-infarction cardiosclerosis without chronic heart failure (CHF), and with Functional Class (FC) II–III CHF (NYHA classification). All participants underwent cardiorespiratory monitoring and QoL assessment (WHOQOL-BREF and SAQL questionnaires). Based on the SAS severity, two subgroups with low (0–10 per hour) and high (11–30 per hour) index of apnoeahypopnoea (AHI) were defined. Results. SAS affected the clinical course and QoL to the greatest extent in patients with CHF. Among effort angina patients, this effect was weaker, while no negative impact of SAS was registered in patients with post-infarction cardiosclerosis without CHF. Conclusion. The management of CHD patients should incorporate the screening for possible SAS and target SAS, if present, as one of the factors aggravating the clinical course of the main pathology. © 2012, Silicea-Poligraf. All rights reserved.


Tverskaya M.S.,rogov Russian Research Medical University | Sukhoparova V.V.,rogov Russian Research Medical University | Karpova V.V.,rogov Russian Research Medical University | Kadyrova M.Kh.,rogov Russian Research Medical University | Klyuchikov V.Yu.,rogov Russian Research Medical University
Bulletin of Experimental Biology and Medicine | Year: 2013

Metabolism of contractile cardiomyocyte in experimental pulmonary stenosis complicated or not complicated by heart failure was studied by histochemical methods. In pulmonary stenosis not complicated by heart failure, intensification of glycolysis, more intense oxidation of free fatty acids and their metabolites, and acceleration of the citric acid cycle were found in the contractile cardiomyocytes. In pulmonary stenosis complicated by heart failure, glycogen content in the myocardium was sharply decreased. The histochemical enzyme profile of contractile cardiomyocytes is similar in pulmonary stenosis with and without heart failure. Comparative analysis of changes occurring in acute increase in afterload of the left or right ventricle suggested that in the latter case, metabolic abnormalities in the contractile cardiomyocytes are relatively unimportant in the pathogenesis of heart failure. © 2013 Springer Science+Business Media New York.


PubMed | rogov Russian Research Medical University
Type: Comparative Study | Journal: Bulletin of experimental biology and medicine | Year: 2014

The expression profiles of 10 mature microRNA (7, 10a, 17, 20a, 21, 23a, 26a, 137, 222) in biopsy specimens of gliomas of different malignancy were studied by the real time PCR with SYBR Green I fluorescent stain. The expression of microRNA-21 increased significantly, while that of microRNA-137 decreased, depending on the tumor malignancy. The expression of microRNA-9, -17, -20a, -23a, -26a was significantly higher, while that of microRNA-7 lower in the tumor vs. control tissue samples. New data on the molecular pathological mechanisms of gliomas related to their malignancy were obtained. Quantitative analysis of microRNA was suggested as a potential diagnostic marker of brain tumors.


PubMed | Research Institute of Cardiology and rogov Russian Research Medical University
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

Experimental study of a new paramagnetic complex Mn-DCTA is carried out. The complex (0.5 M manganese(II) solution with trans-1,2-diamine cyclohexane-N,N,N,N-tetraacetic acid; Cyclomang) was used for contrast magnetic resonance imaging visualization of CNS involvement in dogs with severe forms of Babesia canis infection. CNS injuries were visualized in all cases, with highly intense contrasting at the expense of Mn-DCTA accumulation at the periphery of the damaged zone. Quantitative evaluation of the paramagnetic accumulation in the focus showed that the amplification index wa s 1.190.11 for the central areas and 1.470.17 for the peripheral ones. The pituitary (1.180.05) and vascular plexuses of the lateral ventricles (1.120.09) were also contrasted. Injection of the paramagnetic to dogs was not associated with any kinds of pathological or physiological reactions. Mn-DCTA complex allowed contrast visualization of the focal injuries to the CNS and could be regarded as a paramagnetic contrast agent for magnetic resonance imaging of brain injuries in dogs.

Loading rogov Russian Research Medical University collaborators
Loading rogov Russian Research Medical University collaborators