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Taratukhin E.O.,rogov Russian National Medical University
Cardiovascular Therapy and Prevention (Russian Federation) | Year: 2012

The paper considers arterial hypertension and coronary heart disease as pathologies which share multiple pathogenetic mechanisms. The role of angiotensin Il receptor antagonists (ARA) in the effective treatment of these diseases and in prevention of their complications is discussed. The modern views on ARA and their indications are presented. Source


Shayduk O.Y.,rogov Russian National Medical University | Taratukhin E.O.,rogov Russian National Medical University
Cardiovascular Therapy and Prevention (Russian Federation) | Year: 2012

The paper discusses key aspects of the chronic heart failure (CHF) pathogenesis, which justify the use of ß-adrenoblockers (ß-AB) in the treatment of CHF. The authors present the clinical and experimental evidence confirming the effectiveness of these agents in CHF patients. Dose titration and the use of ß-AB in various clinical groups are also discussed. Source


Vorobyeva N.M.,Russian Cardiology Clinical and Scientific Complex | Panchenko E.P.,Russian Cardiology Clinical and Scientific Complex | Dobrovolskyi A.B.,Russian Cardiology Clinical and Scientific Complex | Titaeva E.V.,Russian Cardiology Clinical and Scientific Complex | And 5 more authors.
Russian Journal of Cardiology | Year: 2012

Aim. To study the factors associated with elevated D‑dimer levels in patients with acute venous thromboembolic events (VTEE). Material and methods. The study included 111 patients (76 men and 35 women aged 18–76 years) with a first or repeat episode of deep vein thrombosis (DVT) and/or pulmonary embolism (PE) in the last 2 months. The majority of the patients (n=80) received unfractionated heparin (UFH) for at least 5 days, followed by warfarin (international normalized ratio (INR) control at least once a month; target INR 2,0–3,0). Some patients (n=31) received therapeutic doses of enoxaparin (1 mg/kg subcutaneously, every 12 hours) for at least 30 days, followed by warfarin treatment. D‑dimer levels (norm <0,5 mkg/ml) were measured by the latex agglutination method, with the use of “STA LIATEST® D‑DI” reagents (Diagnostica Stago). Results. D‑dimer levels varied from 0,02 to 9,96 mkg/ml (median 1,05 mkg/ml, interquartile range 0,49–1,99 mkg/ml) and exceeded the upper norm limit in 74% of the patients. There was a positive association between D‑dimer levels and thrombus “size” (r=0,304; p<0,001), and a negative association between D‑dimer levels and thrombus “age” (r=-0,418; p<0,001). Predictors of D‑dimer elevation were identified among 150 demographic, anthropometric, anamnestic, clinical, laboratory, genetic, or ultrasound parameters and VTEE risk factors. The results of the multivariate stepwise regression analysis demonstrated that female gender, chronic heart failure (CHF), VTEE symptom duration <28 days, and thrombus “size” >6 points were independent predictors of D‑dimer elevation in the acute period of DVT/PE. Conclusion. D‑dimer levels, measured 32 (23–44) days after the development of DVT/PE symptoms, were elevated in 74% of the patients. D‑dimer elevation in the acute period of VTEE was associated with female gender, CHF, “age” and “size” of the thrombus. © 2012, Silicea-Poligraf, All Rights Reserved. Source


Dugieva M.Z.,rogov Russian National Medical University | Kotenko K.V.,rogov Russian National Medical University | Morozova K.V.,rogov Russian National Medical University
Antibiotiki i Khimioterapiya | Year: 2012

The aim of the study was to estimate the use of hypoxen (antihypoxant) during the early postoperative course in gynecologic patients. The patients were divided into two groups according to the treatment scheme. 339 patients of the control group were under the routine therapy after the Iaparatomic gynecologic operations. 52 patients were additionally treated with hypoxen (antioxidant) (the main group). The impact of hypoxen on the antioxidant system and lipid peroxidation and its preventive effect on prolongation of the postoperative pain syndrom were estimated. The results of the study showed that hypoxen inhibited lipid peroxidation and activated the antioxidant system in the postoperative patients vs. the control group. It was also observed that among the patients additionally treated with hypoxen the percentage of those with prolonged postoperative pains was statistically lower (p<0.05, x2 test). It was concluded that hypoxen normalized lipid peroxidation and antioxidant system after abdominal gynecologic operations. The additional use of hypoxen in the routine therapy of the gynecologic patients prevented prolongation of the postoperative pain syndrom. Source


Delger A.B.,rogov Russian National Medical University | Avakyan G.N.,rogov Russian National Medical University | Oleinikova O.M.,rogov Russian National Medical University | Bogomazova M.A.,rogov Russian National Medical University | And 2 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2012

The efficiency and safety of tenoten for anxiety and depression disorders in epileptics has been demonstrated. The drug does not change the incidence and severity of epileptic episodes, does not deteriorate the course of the underlying disease, and can be well combined with anticonvulsants. The results indicate the efficiency of tenoten used to arrest the anxio-depressive disorders in epilepsy. © 2012 Springer Science+Business Media New York. Source

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