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Wixom, MI, United States

Boman D.,Texas Tech University Health Sciences Center | Bilbao J.,Texas Tech University Health Sciences Center | Gupta A.,Rockwell Medical
Clinical Nephrology | Year: 2013

Background: Parenteral iron therapy is the mainstay of treating iron deficiency anemia in chronic kidney disease (CKD) patients. Methods: Retrospective case study of iron staining of renal tissues in 2 CKD patients who had received intravenous iron prior to the renal biopsy. Results: Following the infusion of ferumoxytol, iron staining of renal biopsy demonstrated blue curvilinear depostiion of iron in the tissue macrophages (histocytes) and interstitium of the kidney. Renal iron depostiion was not observed in a patient administered intravenous iron dextran. Conclusion: We postulate that the higher molecular weight of ferumoxytol and different carbohydrate components may lead to depostiion and trapping of the ironcarbohydrate complexes in the reticuloendothelial system of the kidney. Potential renal toxicity from iron induced oxidant stress, especially in patients with underlying chronic kidney disease, merits further investigation. Source


Ritu G.,Charak Foundation | Gupta A.,Charak Foundation | Gupta A.,Rockwell Medical
Nutrients | Year: 2014

Vitamin D deficiency prevails in epidemic proportions all over the Indian subcontinent, with a prevalence of 70%-100% in the general population. In India, widely consumed food items such as dairy products are rarely fortified with vitamin D. Indian socioreligious and cultural practices do not facilitate adequate sun exposure, thereby negating potential benefits of plentiful sunshine. Consequently, subclinical vitamin D deficiency is highly prevalent in both urban and rural settings, and across all socioeconomic and geographic strata. Vitamin D deficiency is likely to play an important role in the very high prevalence of rickets, osteoporosis, cardiovascular diseases, diabetes, cancer and infections such as tuberculosis in India. Fortification of staple foods with vitamin D is the most viable population based strategy to achieve vitamin D sufficiency. Unfortunately, even in advanced countries like USA and Canada, food fortification strategies with vitamin D have been only partially effective and have largely failed to attain vitamin D sufficiency. This article reviews the status of vitamin D nutrition in the Indian subcontinent and also the underlying causes for this epidemic. Implementation of population based educational and interventional strategies to combat this scourge require recognition of vitamin D deficiency as a public health problem by the governing bodies so that healthcare funds can be allocated appropriately. © 2014 by the authors; licensee MDPI, Basel, Switzerland. Source


Tolouian R.,Texas Tech University Health Sciences Center | Hernandez G.T.,Texas Tech University Health Sciences Center | Chiang W.-Y.,Chander Medical Associates Inc. | Gupta A.,Rockwell Medical
European Journal of Internal Medicine | Year: 2010

Background: The validity of serum parathyroid hormone (PTH) as a surrogate marker of bone turnover in chronic kidney disease (CKD) is limited by several factors such as relative resistance of bone to PTH, hyperphosphatemia, diabetes, gender, age, race and vitamin D analog action on the PTH-bone axis. Urinary collagen N-terminal telopeptide X (NTx), a bone collagen degradation product, expressed as bone collagen equivalents (BCE) per mM of creatinine (NTx/Cr ratio), is routinely used to estimate bone turnover in osteoporosis. The purpose of this study is to evaluate NTx as a marker of bone turnover in CKD. Methods: We studied the relationship between bone-specific alkaline phosphatase (BSAP), PTH and urine NTx/Cr in 37 CKD out-patients. Results: In a multivariate model, PTH had a positive correlation with BSAP (r = 0.44, P < 0.19) and U-NTx/Cr (r = 0.55, P < 0.30), after adjusting for age, gender, estimated glomerular filtration rate (GFR), serum phosphorus, corrected calcium, and race. However, the strongest correlation was found between the two direct markers of bone resorption and formation (U-NTx vs. BSAP; r = 0.80; P < 0.0001), suggesting a tight coupling of bone resorption and formation in CKD. The effect of gender on U-NTx/Cr was studied in a multivariate model after adjusting for age, race, GFR, serum calcium, phosphorus and PTH. Females had a higher U-NTx/Cr than males. Conclusion: Our findings indicate that urinary NTx, a promising marker of bone resorption in CKD patients, exhibits a strong positive correlation with other markers used to assess renal osteodystrophy i.e. PTH and BSAP. Unlike PTH and BSAP, urine NTx also measures bone loss secondary to osteoporosis. Source


Trademark
Rockwell Medical | Date: 2016-05-31

Preparations for use in clinical and medical dialysis procedures; pharmaceutical solutions used in dialysis and hemodialysis; pharmaceutical preparations, namely, preparations for treating iron deficiency, anemia, kidney disease and renal disease; pharmaceutical preparations for injection, namely, preparations for treating iron deficiency, anemia, kidney disease and renal disease; iron delivery therapy, namely, commercial iron nutritional supplements, intravenous fluids used for the delivery of iron and soluble ferric pyrophosphate, all goods containing ferric pyrophosphate citrate.


News Article | June 15, 2015
Site: www.xconomy.com

Here’s a look at news you may have missed from around Michigan’s innovation hubs: —The University of Michigan and the Michigan Economic Development Corporation (MEDC) announced last week that they’re launching a crowdfunding campaign on Patronicity to transform a vacant 3,200-square-foot building on the Detroit Community Schools campus into the Brightmoor Maker Space, a place where kids and adults can incubate ideas and try to build what they envision. The Knight Foundation awarded U-M a two-year, $100,000 matching grant for the project as part of Detroit’s Knight Arts Challenge program. The campaign has so far raised just under $6,000 out of a goal to bring in $25,000 by July 10. The MEDC will match funding through its Public Spaces Community Places initiative, which is a collaboration between the MEDC, the Michigan Municipal League, and Patronicity. —Ford announced that it has opened a one-stop 3D digital shop, where people can use advanced technology to make their own models of Ford vehicles or purchase 3D digital files from a growing library of more than 1,000 Ford vehicle images. The 3D printed models are plastic at 1/32nd scale, and available models include the Ford GT, F-150 Raptor, Focus, and Fiesta. Ford hired TurboSquid to handle order fulfillment and other logistics. —Wixom’s Rockwell Medical has hit another milestone: It has received a Q-code assignment for its Triferic product, meaning it will now be easier for dialysis centers to bill insurance for reimbursement. Triferic is the only iron product that is FDA approved for delivery via dialysate to replace iron and maintain hemoglobin to treat anemia in hemodialysis patients. The new Q-code will go into effect on July 1. Sarah Schmid is the editor of Xconomy Detroit/Ann Arbor. You can reach her at 313-570-9823 or sschmid@xconomy.com. Follow @XconomyDET_AA

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