Jabalpur, India
Jabalpur, India

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Likhitkar S.,Robertson College, Jabalpur | Bajpai A.K.,Robertson College, Jabalpur
Carbohydrate Polymers | Year: 2012

The present study involves a novel strategy for the preparation of superparamagnetic nanoparticles of crosslinked starch impregnated with homogeneously dispersed nanosized iron oxide. The nanoparticles were loaded with an anticancer drug 'cisplatin' and the drug release kinetics was investigated spectrophotometrically at physiological pH (7.4). The nanoparticles were characterized by Fourier transform infra red (FTIR) spectroscopy, transmission electron microscopy (TEM), X-ray diffraction and magnetization studies. The particle size of magnetic starch nanoparticles was found to lie in the range of 20-90 nm. The influence of factors like chemical composition of nanoparticles, pH and temperature of the release media and applied magnetic field was investigated on the release profiles of the drug. The prepared nanoparticles could provide a possible pathway for targeted and controlled delivery of anticancer drugs minimizing side effects and achieving higher efficacy. © 2011 Elsevier Ltd. All Rights Reserved.

Bajpai A.K.,Robertson College, Jabalpur | Gupta R.,Robertson College, Jabalpur
Polymer Composites | Year: 2010

The aim of this investigation was to design iron oxide containing nanocomposites which could display superparamagnetic behavior and thus find application in biomedical and allied fields. To achieve the proposed objectives methyl methacrylate was polymerized by a redox system comprising of metabisulphite and persulphate in the immediate presence of a crosslinker, N,N0- methylene bis acrylamide and a preformed polymer, i.e., polyvinyl alcohol. Into the prepared polymer matrix nanosized magnetite (Fe3O4) particles were evenly dispersed by in situ precipitation of Fe 2+/Fe3+ ions. The nanocomposite materials were characterized by techniques like FTIR, SEM, TEM, XRD, and DSC. The magnetic behavior of nanocomposites and bulk magnetite particles was studied under varying applied magnetic fields and their superparamagnetic property was examined. The iron-oxide polymer nanocomposites were also studied for microhardness. POLYM. COMPOS., 31:245255, 2010. Copyright © 2009 Society of Plastics Engineers.

Bajpai A.K.,Robertson College, Jabalpur | Bajpai J.,Robertson College, Jabalpur | Saini R.,Robertson College, Jabalpur | Gupta R.,Robertson College, Jabalpur
Polymer Reviews | Year: 2011

Modern synthetic polymer chemistry has revolutionized the world of polymer materials. Among macromolecular systems of various chemical and architectural profiles the polymers exhibiting property of responsiveness to external signals have emerged as one of the most promising kind of materials in advanced materials science and owe versatile applications in biology and technology. The internal structural designs of these materials enable them to undergo a large and measurable transition in their physicochemical characteristics upon responding to a minor change in the external environment including experimental conditions. The present article reviews the state-of-the-art of the applications of various stimuli responsive polymers and describes their structure-property relationships. The article provides an account of different aspects of stimuli responsive macromolecular systems that include types of systems responsive to various stimuli such as pH, temperature, electric and magnetic fields, different biomolecules, etc. This review article also presents insights into synthetic strategies of these polymer systems and their major applications in areas such as controlled drug delivery, chromatography, sensors, biotechnology, etc. A brief mention of various challenges ahead and the future scope of this field has also been made. Copyright © Taylor & Francis Group, LLC.

Chouhan R.,Robertson College, Jabalpur | Bajpai A.K.,Robertson College, Jabalpur
Nanomedicine: Nanotechnology, Biology, and Medicine | Year: 2010

Swellable polymeric nanosystems have emerged as promising materials in drug release technologies. Such systems have shown potential in releasing antibiotic drugs and to do so controllably. In the present investigation poly(2-hydroxyethyl methacrylate) nanoparticles were synthesized by suspension polymerization of 2-hydroxyethyl methacrylate and characterized by various techniques such as Fourier transform-infrared spectrometry, scanning electron microscopy, particle size analysis, and surface charge measurements. The synthesized nanoparticles were swellable in water and showed promise to function as a swelling controlled-release system. The release kinetics of drug-loaded particles was studied in phosphate-buffered saline (PBS) using ciprofloxacin as a model antibacterial drug. The chemical stability of the pure and released drug was also assessed in PBS (pH 7.4), acidic (pH 1.8), and alkaline (pH 8.6) solutions. The in vitro blood compatibility of nanoparticles was also investigated in terms of hemolysis tests. The drug-loaded nanoparticles were also examined for their antibacterial and blood-compatible behaviors. From the Clinical Editor: Swellable polymeric nanosystems have emerged as promising materials in drug release technologies. In this paper, the release kinetics, antimicrobial properties and in vitro "blood compatibility" is reported for a specific swellable polymeric nanosystem. © 2010 Elsevier Inc. All rights reserved.

Bajpai A.K.,Robertson College, Jabalpur | Gupta R.,Robertson College, Jabalpur
Journal of Materials Science: Materials in Medicine | Year: 2011

Polymer nanocomposites exhibiting superparamagnetic behavior have been recognized as a promising tool to achieve targeted drug delivery using external magnetic field for treating complex diseases like cancers and tumors. The present investigation attempts to design a superparamagnetic nanocomposite which could desirably deliver ciprofloxacin drug by application of varying magnetic field. In order to achieve the proposed objectives, a polymer matrix of polyvinyl alcohol-g-polymethyl methacrylate was prepared by free radical polymerization and iron oxide particles were impregnated by in situ precipitation method. The prepared nanocomposites were characterized by techniques like FTIR, electron microscopy (SEM and TEM) and XRD and magnetization studies were performed to ensure superparamagnetic behavior. The antibiotic drug ciprofloxacin was loaded onto the magnetic nanocomposites and the influence of various factors such as percent loading, chemical composition of the nanocomposite, applied magnetic field, pH of the release medium were investigated on the release profiles of the drug. The chemical integrity of the drug and its antibacterial potential were also studied. The dynamics of the release process was also examined mechanistically. © 2010 Springer Science+Business Media, LLC.

Gupta R.,Robertson College, Jabalpur | Bajpai A.K.,Robertson College, Jabalpur
Journal of Biomaterials Science, Polymer Edition | Year: 2011

Tailored with superparamagnetic properties the magnetic nanocomposites have been thoroughly investigated in recent past because of their potential applications in the fields of biomedicine and bioengineering such as protein detection, magnetic targeted drug carriers, bioseparation, magnetic resonance imaging contrast agents and hyperthermia. Magnetic drug targeting has come up as a safe and effective drug-delivery technology, i.e., with the least amount of magnetic particles a maximum of drug may be easily administered and transported to the site of choice. In the present work novel magnetic drug-targeting carriers consisting of magnetic nanoparticles encapsulated within a smart polymer matrix with potential of controlled drug release is described. To make such magnetic polymeric drug-delivery systems, both the magnetic nanoparticles and antibiotic drug (ciprofloxacin) were incorporated into the hydrogel. The controlled release process and release profiles were investigated as a function of experimental protocols such as percent loading of drug, chemical composition of the nanocomposite, pH of release media and strength of magnetic field on the release profiles. The structure, morphology and compositions of magnetic hydrogel nanocomposites were characterized by FT-IR, TEM, XRD and VSM techniques. It was found that magnetic nanocomposites were biocompatible and superparamagnetic in nature and could be used as a smart drug carrier for controlled and targeted drug delivery. © 2011 Koninklijke Brill NV, Leiden.

Jain S.,Robertson College, Jabalpur | Bajpai A.K.,Robertson College, Jabalpur
Designed Monomers and Polymers | Year: 2013

Polyethylene glycol (PEG)-based semi-IPNs have been widely used as hydrogel matrices in tissue engineering applications because of their inherent hydrophilicity and biocompatibility. Today, synthetic scaffolds are being widely used in tissue engineering and allied applications because they offer the ability to precisely control the mechanical properties, morphology, and blood compatibility of the materials. In this regard, an attempt has been made to develop scaffolds membranes by judiciously combining PEG, polyvinyl alcohol, and polymethyl methacrylate. The so prepared hydrogel membranes were undertaken for structural, morphological, and thermal characterization using FTIR, scanning electron microscope (SEM), and DSC techniques, respectively. The hydrogel films were investigated for water sorption capacity under various experimental conditions such as changing chemical composition of the membrane, different pH, and temperature of the swelling media and varying simulated biological fluids. The hydrogel membranes were also studied for their catholicity and in vitro blood compatibility property by following several tests such as blood clot formation, percent haemolysis, and protein adsorption. © 2012 Taylor & Francis.

Chhatri A.,Robertson College, Jabalpur
Biomatter | Year: 2011

In this study, the development and characterization of novel polymer blends based on chitosan-poly (vinyl alcohol) and physically cross-linked by freeze-thaw method for possible use in a variety of biomedical application is reported. The present investigation deals with designing savlon-loaded blend hydrogels (coined as cryogels) of poly (vinyl alcohol) (PVA) and chitosan by repeated freeze-thaw method and their characterization by SEM and FTIR techniques. The FTIR spectra clearly reveal that savlon-loaded chitosan and PVA blends are bonded together through hydrogen bonding. The SEM analysis suggests that cryogels show a well-defined porous morphology. The prepared cryogels were also investigated for swelling and deswelling behaviors. The results reveal that both the swelling and deswelling behaviors greatly depend on factors like chemical composition of the cryogels, number of freeze-thaw cycles, pH and temperature of the swelling bath. The savlon-loaded blends were also investigated for their in vitro blood compatibility and antibacterial activity.

Bajpai S.K.,Robertson College, Jabalpur | Shrivastava S.,Robertson College, Jabalpur
Journal of Applied Polymer Science | Year: 2011

In this study, a new sorbent, a poly(acrylamide-co-itaconic acid) [P(AAm-co-IA)]/activated charcoal (AC) composite, was prepared by the aqueous polymerization of acrylamide and itaconic acid in the presence of AC with N,N′-methylene bisacrylamide as a crosslinker and potassium persulfate as an initiator. The P(AAm-co-IA)/AC composite sorbent showed a fair capacity to adsorb the cationic dye methylene blue. The maximum sorption capacity, as studied at 23, 37, and 50°C and determined with the Langmuir isotherm model, was found to be 909.0, 312.5, and 192.3 mg/g, respectively. For an initial concentration of 5 mg/L, the kinetic uptake data were studied with various kinetic models. The pseudo-second-order equation was found to fairly fit the uptake data with a regression value of 0.999. The dye uptake increased with the pH of the sorbate solution, and the optimum pH was found to be in the range of 7-10. Intraparticle diffusion was also observed to take place, and the coefficient of intraparticle diffusion was evaluated to be 26.51 × 10 -2 mg g-1 min-1/2. The various thermodynamic parameters were also determined to predict the nature of the uptake process. The sorption process was found to be spontaneous, as indicated by a negative standard free energy change. The negative standard enthalpy change suggested an exothermic nature for the uptake. © 2010 Wiley Periodicals, Inc.

Choubey J.,Robertson College, Jabalpur | Bajpai A.K.,Robertson College, Jabalpur
Journal of Materials Science: Materials in Medicine | Year: 2010

Gelatin (Type B) nanoparticles were prepared by a single W/O emulsion technique and characterized by infrared (IR) spectra, transmission electron micrographs (TEM), surface potential measurements and magnetization studies. Whereas the IR spectra clearly confirmed the presence of gelatin, genipin and doxorubicin in the loaded nanoparticles, the transmission electron micrographs (TEM) image depicts smooth surface, spherical shape and non-uniform size of nanoparticles (up to 100 nm). The prepared nanoparticles were loaded with doxorubicin, a well known anticancer drug, and in vitro release dynamics of entrapped drug was investigated as a function of various experimental factors such as percent loading of the drug, chemical architecture of the nanocarriers, and pH, temperature, ionic strength and nature of the release medium in presence and absence of magnetic field. The nanoparticles were also studied for their water sorption capacity. The drug release process was analyzed kinetically using Ficks power law and a correlation was established between the quantity of released drug and swelling of the nanoparticles. © Springer Science+Business Media, LLC 2010.

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