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Jabalpur, India

Gupta R.,Robertson College, Jabalpur | Bajpai A.K.,Robertson College, Jabalpur
Journal of Biomaterials Science, Polymer Edition | Year: 2011

Tailored with superparamagnetic properties the magnetic nanocomposites have been thoroughly investigated in recent past because of their potential applications in the fields of biomedicine and bioengineering such as protein detection, magnetic targeted drug carriers, bioseparation, magnetic resonance imaging contrast agents and hyperthermia. Magnetic drug targeting has come up as a safe and effective drug-delivery technology, i.e., with the least amount of magnetic particles a maximum of drug may be easily administered and transported to the site of choice. In the present work novel magnetic drug-targeting carriers consisting of magnetic nanoparticles encapsulated within a smart polymer matrix with potential of controlled drug release is described. To make such magnetic polymeric drug-delivery systems, both the magnetic nanoparticles and antibiotic drug (ciprofloxacin) were incorporated into the hydrogel. The controlled release process and release profiles were investigated as a function of experimental protocols such as percent loading of drug, chemical composition of the nanocomposite, pH of release media and strength of magnetic field on the release profiles. The structure, morphology and compositions of magnetic hydrogel nanocomposites were characterized by FT-IR, TEM, XRD and VSM techniques. It was found that magnetic nanocomposites were biocompatible and superparamagnetic in nature and could be used as a smart drug carrier for controlled and targeted drug delivery. © 2011 Koninklijke Brill NV, Leiden.

Chouhan R.,Robertson College, Jabalpur | Bajpai A.K.,Robertson College, Jabalpur
Nanomedicine: Nanotechnology, Biology, and Medicine | Year: 2010

Swellable polymeric nanosystems have emerged as promising materials in drug release technologies. Such systems have shown potential in releasing antibiotic drugs and to do so controllably. In the present investigation poly(2-hydroxyethyl methacrylate) nanoparticles were synthesized by suspension polymerization of 2-hydroxyethyl methacrylate and characterized by various techniques such as Fourier transform-infrared spectrometry, scanning electron microscopy, particle size analysis, and surface charge measurements. The synthesized nanoparticles were swellable in water and showed promise to function as a swelling controlled-release system. The release kinetics of drug-loaded particles was studied in phosphate-buffered saline (PBS) using ciprofloxacin as a model antibacterial drug. The chemical stability of the pure and released drug was also assessed in PBS (pH 7.4), acidic (pH 1.8), and alkaline (pH 8.6) solutions. The in vitro blood compatibility of nanoparticles was also investigated in terms of hemolysis tests. The drug-loaded nanoparticles were also examined for their antibacterial and blood-compatible behaviors. From the Clinical Editor: Swellable polymeric nanosystems have emerged as promising materials in drug release technologies. In this paper, the release kinetics, antimicrobial properties and in vitro "blood compatibility" is reported for a specific swellable polymeric nanosystem. © 2010 Elsevier Inc. All rights reserved.

Bajpai A.K.,Robertson College, Jabalpur | Gupta R.,Robertson College, Jabalpur
Journal of Materials Science: Materials in Medicine | Year: 2011

Polymer nanocomposites exhibiting superparamagnetic behavior have been recognized as a promising tool to achieve targeted drug delivery using external magnetic field for treating complex diseases like cancers and tumors. The present investigation attempts to design a superparamagnetic nanocomposite which could desirably deliver ciprofloxacin drug by application of varying magnetic field. In order to achieve the proposed objectives, a polymer matrix of polyvinyl alcohol-g-polymethyl methacrylate was prepared by free radical polymerization and iron oxide particles were impregnated by in situ precipitation method. The prepared nanocomposites were characterized by techniques like FTIR, electron microscopy (SEM and TEM) and XRD and magnetization studies were performed to ensure superparamagnetic behavior. The antibiotic drug ciprofloxacin was loaded onto the magnetic nanocomposites and the influence of various factors such as percent loading, chemical composition of the nanocomposite, applied magnetic field, pH of the release medium were investigated on the release profiles of the drug. The chemical integrity of the drug and its antibacterial potential were also studied. The dynamics of the release process was also examined mechanistically. © 2010 Springer Science+Business Media, LLC.

Bajpai A.K.,Robertson College, Jabalpur | Gupta R.,Robertson College, Jabalpur
Polymer Composites | Year: 2010

The aim of this investigation was to design iron oxide containing nanocomposites which could display superparamagnetic behavior and thus find application in biomedical and allied fields. To achieve the proposed objectives methyl methacrylate was polymerized by a redox system comprising of metabisulphite and persulphate in the immediate presence of a crosslinker, N,N0- methylene bis acrylamide and a preformed polymer, i.e., polyvinyl alcohol. Into the prepared polymer matrix nanosized magnetite (Fe3O4) particles were evenly dispersed by in situ precipitation of Fe 2+/Fe3+ ions. The nanocomposite materials were characterized by techniques like FTIR, SEM, TEM, XRD, and DSC. The magnetic behavior of nanocomposites and bulk magnetite particles was studied under varying applied magnetic fields and their superparamagnetic property was examined. The iron-oxide polymer nanocomposites were also studied for microhardness. POLYM. COMPOS., 31:245255, 2010. Copyright © 2009 Society of Plastics Engineers.

Jain S.,Robertson College, Jabalpur | Bajpai A.K.,Robertson College, Jabalpur
Designed Monomers and Polymers | Year: 2013

Polyethylene glycol (PEG)-based semi-IPNs have been widely used as hydrogel matrices in tissue engineering applications because of their inherent hydrophilicity and biocompatibility. Today, synthetic scaffolds are being widely used in tissue engineering and allied applications because they offer the ability to precisely control the mechanical properties, morphology, and blood compatibility of the materials. In this regard, an attempt has been made to develop scaffolds membranes by judiciously combining PEG, polyvinyl alcohol, and polymethyl methacrylate. The so prepared hydrogel membranes were undertaken for structural, morphological, and thermal characterization using FTIR, scanning electron microscope (SEM), and DSC techniques, respectively. The hydrogel films were investigated for water sorption capacity under various experimental conditions such as changing chemical composition of the membrane, different pH, and temperature of the swelling media and varying simulated biological fluids. The hydrogel membranes were also studied for their catholicity and in vitro blood compatibility property by following several tests such as blood clot formation, percent haemolysis, and protein adsorption. © 2012 Taylor & Francis.

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