Robert Bosch GmbH , or Bosch, is a German multinational engineering and electronics company headquartered in Gerlingen, near Stuttgart, Germany. It is the world's largest supplier of automotive components measured by 2011 revenues. The company was founded by Robert Bosch in Stuttgart in 1886.Bosch's core products are automotive components , industrial products and building products .Bosch has more than 350 subsidiaries across over 60 countries and its products are sold in around 150 countries. Bosch employs around 306,000 people and had revenues of approximately €52.5 billion in 2012. In 2012 it invested around €4.8 billion in research and development and applied for around 4,800 patents worldwide. In 2009 Bosch was the leader in terms of numbers of patents at the German Patent and Trade Mark Office with 3,213 patents.However, Bosch continued to extend its international footprint through company acquisitions and investments in new plants, and will continue along with this path in 2013. For example, the Bosch Group is planning to set up a manufacturing site for automotive windshield-wiper systems near Belgrade, Serbia. By 2019 some 70 million euros will be invested. Construction work was set to begin in early 2012, with production due to commence at the start of 2013. Initially, some 60 associates will work in manufacturing operations with a floor area of around 22,000 square meters. By 2019 the number of associates is set to rise to some 620. Its objectives are to achieve a better increase in sales than in 2012 and to improve result significantly.Robert Bosch GmbH is privately owned, and 92% of its share capital is held by Robert Bosch Stiftung GmbH, a charitable foundation. The majority of voting rights are held by Robert Bosch Industrietreuhand KG, an industrial trust. The remaining shares are held by the Bosch family and by Robert Bosch GmbH. The Bosch logo represents a simple magneto armature and casing, one of the company's first products. Wikipedia.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-24-2015 | Award Amount: 6.35M | Year: 2016
The TrimBot2020 project will research the robotics and vision technologies to prototype the first outdoor garden trimming robot. The robot will navigate over varying terrain, approach rose bushes, hedges and boxwood topiary, to trim them to an ideal shape. The robot will be based on a modified Bosch Indego robot lawnmower, which will navigate using a user-defined garden map and 3D scene analysis, and then visually servo a novel electric plant cutter. Achieving this will require a combination of robotics and 3D computer vision research and innovation activities. Original developments will be required for 3D sensing of semi-regular surfaces with physical texture (overgrown plant surfaces), coping with outdoor lighting variations, self-localising and navigating over real terrain and around obstacles, visual servoing to align the vehicle with potentially moving target plants, visual servoing to align leaf and branch cutters to a compliant surface, and innovative engineering to deliver all this on a small battery-powered consumer-grade vehicle. Development of these capabilities aligns closely with the Robotics Strategic Research Agenda and Multi-Annual Roadmap aspirations. This project falls clearly in the consumer market domain. It will develop service robotics, advanced perceptual capabilities, mobile manipulation, and flexible and reactive autonomy. As a novel robotics application, the current TRL is 1/2, but the project aims to achieve TRL 5/6. Bosch expects to exploit the projects results to extend its current automated lawnmower product. This exciting project will extend generic robotics and computer vision technologies, explore a new robot application, has an explicit route to market exploitation by an experienced manufacturer, and has a great team with experienced plant roboticists and world-leading computer vision researchers, led by an experienced EC project coordinator.
Ott G.,Robert Bosch GmbH
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program | Year: 2013
MYC is a potent oncogene initially identified as the target of the t(8;14)(q24;q32) chromosome translocation in Burkitt lymphoma. MYC gene alterations have been identified in other mature B-cell neoplasms that are usually associated with an aggressive clinical behavior. Most of these tumors originate in cells that do not normally express MYC protein. The oncogenic events leading to MYC up-regulation seem to overcome the inhibitory effect of physiological repressors such as BCL6 or BLIMP1. Aggressive lymphomas frequently carry additional oncogenic alterations that cooperate with MYC dysregulation, likely counteracting its proapoptotic function. The development of FISH probes and new reliable antibodies have facilitated the study of MYC gene alterations and protein expression in large series of patients, providing new clinical and biological perspectives regarding MYC dysregulation in aggressive lymphomas. MYC gene alterations in large B-cell lymphomas are frequently associated with BCL2 or BCL6 translocations conferring a very aggressive behavior. Conversely, MYC protein up-regulation may occur in tumors without apparent gene alterations, and its association with BCL2 overexpression also confers a poor prognosis. In this review, we integrate all of this new information and discuss perspectives, challenges, and open questions for the diagnosis and management of patients with MYC-driven aggressive B-cell lymphomas. Source
Halliday G.M.,Robert Bosch GmbH
Seminars in cutaneous medicine and surgery | Year: 2011
Ultraviolet A (UVA) radiation is immunosuppressive and mutagenic in humans and carcinogenic in animals. UVA suppresses immunity with a bell-shaped dose response. At doses equivalent to 15-20 minutes of sun exposure at noon, UVA contributes to approximately 75% of sunlight-induced immunosuppression. A recent action spectrum, indicating that 360-380 nm but not 320-350 nm UVA suppresses immunity in humans, suggests an important role for reactive oxygen species. UVA also causes an energy crisis in cells, and normalization of adenosine triphosphate with nicotinamide prevents UVA immunosuppression. UVA activation of the alternative complement pathway and defects in memory T-cell development are also involved. Human skin cancers contain mutations in the p53 and BRM genes that are consistent with being induced by UVA. UVA is also mutagenic in human skin equivalents. The basal layer of human skin is more susceptible to UVA-induced mutations than the upper layers. Because skin cancers arise from these basal proliferating cells, this finding is likely to be important and could be attributable to low levels of the DNA repair enzyme OGG1 in basal cells. UVA is therefore likely to make a larger contribution to UVA-induced skin carcinogenesis in humans than is predicted by small animal models as the result of being immunosuppressive and mutagenic for basal keratinocytes. Copyright © 2011 Elsevier Inc. All rights reserved. Source
Christensen J.,Robert Bosch GmbH
Journal of the Electrochemical Society | Year: 2010
A mathematical model for diffusion-induced stress generation in spherical Li-ion active materials has been incorporated into Dualfoil, a Li-ion cell-sandwich model with porous electrodes. The model is used to examine differences in the electrochemomechanical response of "power" vs "energy" cells at high currents. Porous electrode effects, particularly in "energy-type" cells with thick electrodes, amplify the peak stresses encountered during lithium insertion and extraction and may result in nonuniform decrepitation or disordering through the depth of the electrode. We also elucidate the roles of fragment connectivity, volume expansion factors, nonlinear lattice expansion, and variable solid-state diffusion on diffusion-induced stress, stress-induced diffusion, and the voltage response of dual-intercalation cells with porous electrodes. In conventional electrode materials (with small volume expansion), pressure diffusion plays a limited role in determining the galvanostatic voltage response but becomes important in determining the stress response. Pressure diffusion and nonlinear lattice expansion play an important role in determining both the voltage and stress response in large-volume-expansion materials (e.g., alloys and perhaps graphite at low utilization). © 2010 The Electrochemical Society. Source
Mahrholdt H.,Robert Bosch GmbH
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance | Year: 2014
The diagnosis of myocarditis is challenging due to its varying clinical presentation. Since myocarditis can be associated with significant 5-year mortality, and postmortem data show myocarditis in almost 10% of all adults suffering sudden cardiac death, individual risk stratification for patients with suspected myocarditis is of great clinical interest. We sought to demonstrate that patients with clinically suspected myocarditis and a normal cardiovascular magnetic resonance (CMR) according to our definition have a good prognosis, independent of their clinical symptoms and other findings. Prospective clinical long-term follow-up of consecutive patients undergoing CMR for work-up of clinically suspected myocarditis at our institution in 2007-2008. Follow-up was available for n=405 patients (all-comers, 54.8% inpatients, 38% outpatient referrals from cardiologists). Median follow-up time was 1591 days. CMR diagnosis was "myocarditis" in 28.8%, "normal" in 55.6% and "other pathology" in 15.6%. Normal CMR was defined as normal left ventricular (LV) volumes and normal left ventricular ejection fraction (LV-EF) in the absence of late Gadolinium Enhancement (LGE). The overall mortality was 3.2%. There were seven cardiac deaths during follow-up, in addition one aborted SCD and two patients had appropriate internal cardioverter defibrillator (ICD) shocks - all of these occurred in patients with abnormal CMR. Kaplan-Meier analysis with log-rank test showed significant difference for major adverse cardiac events (cardiac death, sudden cardiac death (SCD), ICD discharge, aborted SCD) between patients with normal and abnormal CMR (p=0.0003). In our unselected population of consecutive patients referred for CMR work-up of clinically suspected myocarditis, patients with normal CMR have a good prognosis independent of their clinical symptoms and other findings. Source