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Patel R.,University College London | Kumar H.,LRI | More B.,QMC | Patricolo M.,RMCH
BMJ Case Reports | Year: 2013

We present a case of recurrent painful blisters of middle phalanx of the left ring finger of a 15-month-old previously healthy and immunocompetent female child. These lesions initially were confused with infective bacterial whitlow, treated with incision and drainage, and later with cigarette burns which led to referral to child protection team. Paediatric dermatologist finally diagnosed after scrapping and virology culture. The patient had recovery following full treatment with topical and systemic acyclovir. She presented again at the age of 4 with recurrence which required topical and systemic acyclovir therapy with good recovery. It is important to be aware of the danger of incorrect diagnosis, raising child protection concerns and management leading to danger of cross infection and serious illness especially in the immunocompromised patients. Copyright 2013 BMJ Publishing Group. All rights reserved. Source

Kumar A.,Hospital and Research Center | Verma S.K.,RMCH | Bhargava V.,Gsvm Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2012

Background: Air pollution is one of the major problem faced in developing countries like India. Chronic exposure to air pollutants can leads to hampered day today activity and increased visit to clinics. The pollutant PM10 (particulate matter size less than 10 μ) especially a risk factor associated with decreased lung functions. The effect of chronic exposure of different concentration of air pollution level on pulmonary function test is still lacking in India especially in Kanpur, a highly polluted city of U.P., India. Aims & Objective: The present study was conducted to evaluate the impact of chronic exposure of air pollution on lung functions in two differently polluted areas. Materials and methods: One hundred twenty male subjects, in age group of 18 to 30 years from two polluted area of Kanpur, India were participated in the study. Anthropometric data were taken. Pulmonary function test was conducted in standing position. Pollution data of study period was taken from Central pollution control board and compared with the National ambient air quality standard. All data presented as mean ± SD and analysed by independent sample t test by using SPSS version 15. Results: The anthropometric data were statistically not significant in two areas. Forced vital capacity and Forced expiatory flow 25-75% were statistically significantly different (p<0.05) and Peak expiratory flow and Vital capacity were also significantly different in two areas. Conclusion: The long term exposure of pollutant PM10 could reduce the forced vital capacity, Forced expiatory flow 25-75%, Vital capacity and peak expiratory flow. Thus every attempt should be made towards lowering air pollution like alternate fuels such as CNG or hybrid technology. Source

Patel R.V.,University College London | Kumar H.,BCH | Sinha C.K.,NNUH | Patricolo M.,RMCH
BMJ Case Reports | Year: 2013

A case of a prolapsed patent vitellointestinal duct (PVID) in a 10-day-old neonate who presented with vomiting and poor weight gain with partial intestinal obstruction and a flower like pink, prolapsing lesion at his umbilicus has been reported. A limited contrast study through the tubular structure confirmed it to be a PVID. He underwent transumbilical exploration and resection and anastomosis uneventfully. Persistence of the vitellointestinal duct as a whole or part of it leads to a wide variety of anomalies-Meckel's diverticulum is the commonest lesion and a PVID is the rarest. Umbilical cord clamping flush with the abdominal wall may convert a Meckel's diverticulum prolapsing in the base of umbilical ring into a PVID. Careful assessment should be made for associated anomalies. Transumbilical exploration gives the best cosmetic and functional results. © 2013 BMJ Publishing Group. All rights reserved. Source

Asghar A.,RMCH | Naaz H.,RMCH | Agrawa D.,LLRMC | Sharma P.K.,KGMU
Journal of Clinical and Diagnostic Research | Year: 2011

Introduction: A prospective study was done on 126 patients (72 male and 54 female) whose abdominal CT scan was found normal and no disorder was diagnosed which alters the size of spleen to estimate normal linear dimensions of spleen in North Indian adult population. Material & Methods: Collected CT scan were evaluated with the help of Able 3-D doctor software. Body habitus of patients were determined. All linear dimension of spleen - length, width and thickness were calculated and they were analysed with body habitus - Age, height, weight, BSA (body surface area) and BMI (body mass index) was calculated by linear and non-linear regression model to know exact pattern of correlation. Result: The mean length, width and thickness of spleen were 10.67±1.62 cm, 6.26±1.66 cm and 4.86±1.22 cm respectively. Conclusion: All linear splenic dimensions have significant positive correlation with height of patients and normative data can be produced with the help of regression formula developed with the help of statistics which can be used as research tool where objective determination of splenomegaly is required. Source

Asghar A.,RMCH | Yunus S.M.,JNMC | Faruqi N.A.,JNMC
Journal of the Anatomical Society of India | Year: 2012

Twenty-eight healthy fetuses between 11-40 weeks were selected to study the histological and morphological growth of Hassall's corpuscles. We were found that Hassall's corpuscle appreciated earliest at 14th weeks and seen as two to three cells nest in area having degenerated tissues. Later, as the age of fetus advanced the size and shape of Hassall's corpuscles rapidly increasing by additions of more apoptotic cells and aggregation of reticulo-epithelial cells. Near 28th week these corpuscles showed spurt of growth and initially corpuscles were distant from each other, they started to come together e.g. reducing inter-corpuscular distance. In late stage (near term) these corpuscles fused together giving variable shapes and sizes. © 2012 Anatomical Society of India. Source

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