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Harshitha K.R.,Rl Jalappa Hospital And Research Center
Journal of Clinical and Diagnostic Research | Year: 2014

Methods: Ten patients aged 18-30 who underwent anterior segmental osteotomy were included in the study. Preoperative and postoperative records consisted of lateral cephalogram and frontal and lateral photographs. Postoperative measurements were taken six months after surgery.Results: Statistical analysis showed changes in both soft and hard tissue parameters. Changes were not uniform for all the parameters. Upper lip and upper incisor protrusion showed very large effect size whereas nasal tip inclination showed small effect and mentolabial angle showed no effect.Conclusion: Skeletal protrusion pose problem to orthodontists as they can’t be corrected by orthodontics alone. Anterior segmental osteotomy in association with orthodontia is the choice of treatment. Anterior segmental osteotomy allows for functional and aesthetical correction with good success rate and minimal complication.Objective: To determine the relationship between the changes of soft and hard tissues after anterior segmental osteotomy and to evaluate these changes using cepahalometric and photometric analyses. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved. Source


Bose D.,Sri Devaraj Urs Academy of Higher Education and Research | Krishnamurthy V.,Genotypic Technology Pvt Ltd. | Venkatesh K.S.,Rl Jalappa Hospital And Research Center | Aiyaz M.,Genotypic Technology Pvt Ltd. | And 3 more authors.
Cytogenetic and Genome Research | Year: 2015

This study describes a molecular analysis of partial trisomy 14q and partial trisomy 12p in a 5-year-old male child presenting with dysmorphic features, congenital heart disease and global developmental delay. Chromosomal analysis of the patient with GTG bands revealed a 47,XY,+der(14)t(12;14)(p13;q22)mat karyotype; the mother's karyotype was 46,XX,t(12;14)(p13;q22). Further, oligonucleotide array- CGH studies revealed an amplification of 32.3 Mb in the 14q11.1q22.1 region, substantiating partial trisomy 14q and additionally displaying an amplification of ∼1 Mb in the 12p13.3pter region for partial trisomy 12p. This is the first study to demonstrate a novel association of partial trisomies of 14q and 12p due to a 3:1 segregation of a maternal balanced translocation involving chromosomes 12 and 14. Gene ontology studies indicated 5 potential candidate genes in the amplified regions for the observed congenital anomalies. © 2015 S. Karger AG, Basel. Source


Anil Kumar S.V.,Rl Jalappa Hospital And Research Center | Vittal V.,Rl Jalappa Hospital And Research Center | Arya S.,Rl Jalappa Hospital And Research Center | Devadoss A.,Institute of Orthopaedic Research and Accident Surgery
International Journal of Pharma and Bio Sciences | Year: 2015

A retrospective study was conducted to evaluate the results of 59 knee replacements done in 38 patients. Thirty patients replaced with 48 knees were available for the follow-up. The average period of the follow up was 4.5 years. There were 12 males and 18 females with average age of 56.83 years. The diagnosis was osteoarthritis in 21 patients, and rheumatoid arthritis in 9 patients. Eighteen patients underwent bilateral knee replacements (3 RA and 15 OA patients) and 12 patients had unilateral replacement (6 RA, 6 OA).Three types of prostheses were used: Total condylar prosthesis (25 knees), Post and cam type (9 knees), Ultra-congruent deep dish type (14 knees). Type of prosthesis were selected randomly and according to financial status of the patient. Clinical and Functional assessment was done by the knee Society Score (KSS) and Radiological assessment was by Knee Society Total Knee Arthroplasty Roentgenographic Evaluation and Scoring System. We concluded that most of our patients were replaced with Total Condylar Prosthesis knees and some of them had anterior knee pain. This was main reason for low KSS score with Total Condylar Prosthesis knees compared to Ultra-congruent polyethylene and Post and Cam. Even though knees replaced with Ultra-congruent polyethylene and Post and Cam had better KSS clinical and functional scores compared to Total Condylar Prosthesis, it was not statistically significant. Our 87.5% good to excellent results are on par with the other global studies. Source


Chakraborty S.,Indian Institute of Science | Nagashri M.N.,Indian Institute of Science | Nagashri M.N.,Bangalore Institute of Oncology | Mohiyuddin S.M.A.,Rl Jalappa Hospital And Research Center | And 3 more authors.
Indian Journal of Surgical Oncology | Year: 2010

Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide. Despite progress in therapeutic and surgical treatments, its survival period at 5 years is the lowest among major cancers, and remains unchanged in the last two decades. The growing epidemiological relevance of oral cancer emphasizes the need to better understand the molecular mechanisms underlying this disease and identify predictive tumor markers and therapeutic targets. To this end, we have used the DDRT-PCR analysis to profile the oral tumor transcriptome and identify differentially regulated genes that may be used as potential biomarkers and therapeutic targets. Our DDRT-PCR analysis identified 51 differentially expressed fragments, of which 25 were revalidated by reverse Northern analysis. Northern blot analysis further corroborated these findings for a few genes. In order to ascertain the utility of some of the identified genes as molecular markers and therapeutic targets, semi-quantitative RT-PCR analysis was carried out in a panel of matched oral normal and tumor samples, that confirmed GLTP, PCNA, RBM28, C17orf75 and DIAPH1 as significantly upregulated, whereas TNKS2, PAM and TUBB2C showed significant downregulation in tumor samples. Taken together, our DDRT-PCR analysis has revealed several genes, belonging to diverse cellular pathways, that have been associated with OSCC for the first time. Thus, these genes could be investigated as biomarkers and therapeutic targets for OSCC. © 2011 Indian Association of Surgical Oncology. Source


Nagakumar J.S.,Rl Jalappa Hospital And Research Center | Arya S.,Rl Jalappa Hospital And Research Center | Manohar P.V.,Rl Jalappa Hospital And Research Center | Shaikh Nazeer B.,Rl Jalappa Hospital And Research Center
International Journal of Pharma and Bio Sciences | Year: 2014

Fractures of the femoral neck are devastating injuries that most often affects the elderly and have a tremendous impact on the health care system and society in general. Patients who have presented with fracture neck of femur over the age of 60, but have been performing from a functional point of view as a younger individual have been excellent candidates for reduction with internal fixation.Several studies have suggested that reduction and fixation of an intracapsular fracture of the hip with multiple pins or screws is associated with a lower rate of morbidity and mortality than treatment with prosthetic replacement. We evaluated the results with respect to the efficacy of internal fixation by cannulated cancellous screw in terms of survival of the implants, complications, the survival of the patients, and the function of the patients in whom the fracture had healed without the development of osteonecrosis. Source

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