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Tomak Y.,Recep Tayyip Erdogan University | Yalmaz A.,Recep Tayyip Erdogan University | Bostan H.,Recep Tayyip Erdogan University | Tumkaya L.,Recep Tayyip Erdogan University | And 3 more authors.
Anaesthesia | Year: 2012

We investigated the effect of rocuronium- and sugammadex-induced mast cell increase and degranulation in rat portal triads. Forty-two rats, in six groups, received either rocuronium 1 mg.kg -1; sugammadex 15 mg.kg -1; sugammadex 100 mg.kg -1; rocuronium 1 mg.kg -1 and 5 min later, sugammadex 15 mg.kg -1; rocuronium 1 mg.kg -1 and 5 min later, sugammadex 100 mg.kg -1; or isotonic saline. Total mast cell numbers were significantly higher with rocuronium only, than in all other groups (p < 0.003), although in all active groups, the number was greater than the control. Total mast cell number was significantly higher with rocuronium and low-dose sugammadex compared with low-dose sugammadex only. The number of tryptase-positive mast cells with rocuronium only was significantly higher than in all other groups (p < 0.003). Tryptase-positive mast cell numbers in both groups receiving both rocuronium and sugammadex were significantly higher compared with both groups receiving sugammadex only. Rocuronium increased mast cell numbers, and degranulation was mitigated by sugammadex. These results suggest that sugammadex may be beneficial in treatment of rocuronium-induced anaphylaxis. © Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.

Aksu D.,Rize Education and Research Hospital | Peksari Y.,Ankara University | Arica I.E.,Rize 82. Year City Hospital | Gurgey E.,Ankara University
Indian Journal of Dermatology | Year: 2010

Background: In pemphigus, autoantibodies are directed against adhesion molecules, which make the junctions between keratinocytes, and thus determining their level can reflect the disease activity. Aim: The purpose of this study is to determine the clinical significance of the autoantibody levels in pemphigus management. Materials and Methods: The clinical features of 47 pemphigus vulgaris patients were assessed and patients' sera were investigated by indirect immunofluorescence using monkey esophagus as a substrate for autoantibody levels. Results: We found a significant correlation between antibody titers and mucosal severity scores. Initial antibody titers of the patients with at least one mucosal lesion at the end of the first month of the therapy were found significantly higher than the patients who had no mucosal lesion. With the therapy, lesions resolved earlier than the antibody titers. Conclusion: In patients with pemphigus, especially in cases who were not treated before, sera antibody levels are a valuable tool in evaluating disease severity and choosing initial treatment. In patients who had been taking any systemic treatment, it is difficult to make a relationship between antibody levels and disease severity, because therapy improves disease earlier than the antibody titers. However, estimating antibody levels can be helpful for clinicians in disease management, in reducing or ceasing treatment dosage and anticipating recurrence.

Sucu Gunaydin N.,Rize Education and Research Hospital | Aydin K.,Karadeniz Technical University | Yilmaz G.,Karadeniz Technical University | Caylan R.,Ankara Ataturk Education and Research Hospital | Koksal I.,Karadeniz Technical University
Turkish Journal of Medical Sciences | Year: 2010

Aim: Crimean-Congo hemorrhagic fever (CCHF) is a disease that is known since 1944 affecting many people across the world and causing a high mortality rate. The aim of this study was to determine the epidemiological and clinical characteristics of the CCHF cases in our region. Materials and methods: The present study was conducted in patients with CCHF who were hospitalized between 2004 and 2006 at Karadeniz Technical University. Demographic, geographic, climatic, and clinical characteristics of all patients were investigated. Results: A total of 102 patients with confirmed CCHF were investigated in this study. All of the patients were from rural areas. Eighty-seven patients (85.2%) were livestock workers. None of the cases was from the region where mountain range faced the sea and all cases were from areas of Harşit, Kelkit, and Çoruh valleys situated at 1100-2265 m above sea level where the mountain ranges ceased to separate the sea and inner regions and streams reached the sea. Conclusion: CCHF case series have been reported from Turkey as well and particularly Middle Anatolia and northeastern regions have been determined as endemic areas recently. Population of those regions mostly earns their life from livestock breeding and agriculture, which increases the risk of exposure to ticks and development of CCHF. Therefore, especially in cases coming from regions categorized as endemic, it has been concluded that mortality can be reduced by carefully taken medical history and practice of rapid medical treatment and replacement therapies in consideration of CCHF prediagnosis. © TÜBİTAK.

Gucer H.,Recep Tayyip Erdogan University | Bagci P.,Recep Tayyip Erdogan University | Coskunoglu E.Z.,Rize Education and Research Hospital | Karadag C.,Unye State Hospital
Journal of the Pancreas | Year: 2011

Context Heterotopia of the pancreas can be defined as the presence of pancreatic tissue in an abnormal location without any continuity with the main body of the pancreas. Heterotopic pancreatic tissue located in the gallbladder is a rare entity. Despite being a congenital condition, it takes years for heterotopic pancreas to become symptomatic. Case report An 80-year-old male patient presented to our hospital with a two-week history of abdominal pain, nausea and vomiting aggravated after meals. Abdominal ultrasonography revealed minimal wall edema and small grain-sized gallstones in the gallbladder. The patient was hospitalized and laparoscopic cholecystectomy was performed for acute cholecystitis. Pathologic examination showed a 6 mm nodular mass of pancreatic tissue in the gallbladder wall, comprised mainly of ductal and acinic structures and a few endocrine cells. Conclusion We found this case of pancreatic heterotopia worth reporting because of its rare incidence.

Uzun H.,Recep Tayyip Erdogan University | Cicek Y.,Recep Tayyip Erdogan University | Kocaman S.A.,Rize Education and Research Hospital | Durakoglugil M.E.,Recep Tayyip Erdogan University | Zorba O.U.,Recep Tayyip Erdogan University
Scandinavian Journal of Urology | Year: 2013

Objective.Vascular risk factors frequently coexist with lower urinary tract symptoms (LUTS) in both men and women, suggesting that atherosclerosis and endothelial dysfunction may play a major role in the development of LUTS. Arterial stiffness owing to decreased arterial compliance is one of the major signs of vascular ageing, and carotid intima-media thickness (CIMT) can be used in establishing the extent and severity of vascular impairment. This study investigated the association of arterial stiffness and vascular atherosclerotic involvement with LUTS in men and overactive bladder (OAB) in women. Material and methods.This study was prospective and cross-sectional, consisting of 66 patients with LUTS (38 men with LUTS, 28 women with OAB) and 62 controls without LUTS or OAB. Carotid-femoral pulse-wave velocity (CF-PWV) was measured as an index of arterial stiffness. CIMT was measured with B-mode ultrasonography to assess vascular impairment. Results.Patients with LUTS had significantly higher CF-PWV (9.8 ± 2.6 vs 7.0 ± 1.4 m/s, p < 0.001) and CIMT (0.89 ± 0.16 and 0.56 ± 0.31 mm, p < 0.001) compared with controls. Age and glucose were also different between LUTS and control groups (p < 0.001 and p = 0.003, respectively). In the multivariate analyses, both CIMT (= 0.429, p < 0.001) and PWV (= 0.451, p < 0.001) were related to LUTS. Conclusions.Vascular impairment was found to be associated with LUTS in both men and women. Atherosclerosis-related vascular risk factors are also known to be related to LUTS and both disorders may have pathogenic interactions. © 2013 Informa Healthcare.

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