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Yeh C.-H.,National Cheng Kung University | Hung C.-W.,National Cheng Kung University | Wu C.-H.,RITEK Corporation | Lin Y.-C.,National Cheng Kung University
Journal of Micromechanics and Microengineering | Year: 2014

This paper presents a cross-flow filtration chip for separating blood cells (white blood cells, red blood cells, and platelets) and obtaining blood plasma from human blood. Our strategy is to flow the sample solution in parallel to the membrane, which can generate a parallel shear stress to remove the clogging microparticles on the membrane, so the pure sample solution is obtained in the reservoir. The cross-flow filtration chip includes a cross-flow layer, a Ni-Pd alloy micro-porous membrane, and a reservoir layer. The three layers are packaged in a polymethylmethacrylate (PMMA) frame to create the cross-flow filtration chip. Various dilutions of the blood sample (original, 2 × , 3 × , 5 × , and 10×), pore sizes with different diameters (1 μm, 2 μm, 4 μm, 7 μm, and 10 μm), and different flow rates (1 mL/min, 3 mL/min, 5 mL/min, 7 mL/min, and 10 mL/min) are tested to determine their effects on filtration percentage. The best filtration percentage is 96.2% when the dilution of the blood sample is 10 × , the diameter of pore size of a Ni-Pd alloy micro-porous membrane is 2 μm, and the flow rate is 10 mL/min. Finally, for the clinical tests of the immunoglobulin E (IgE) concentration, the cross-flow filtration chip is used to filter the blood of the allergy patients to obtain the blood plasma. This filtered blood plasma is compared with that obtained using the conventional centrifugation based on the enzyme-linked immunosorbent assay. The results reveal that these two blood separation methods have similar detection trends. The proposed filtration chip has the advantages of low cost, short filtration time, and easy operation and thus can be applied to the separation of microparticles, cells, bacteria, and blood. © 2014 IOP Publishing Ltd.


Patent
Ritek Corporation | Date: 2011-09-09

Disclosed herein is a recording material for an optical recording medium. The recording material has a composition represented by a general formula of Bi


Patent
Ritek Corporation | Date: 2010-12-21

Disclosed herein is a nano-fabrication method, which includes the step of: (a) forming an inorganic resist layer on a substrate; (b) forming an organic photoresist layer on the inorganic resist layer; (c) irradiating both the organic photoresist layer and the inorganic resist layer with a laser beam to form a first exposed region of the inorganic resist layer and a second exposed region of the organic photoresist layer; (d) removing the inorganic resist layer of the first exposed region and the organic photoresist layer of the second exposed region to form a patterned inorganic resist layer and a patterned organic photoresist layer; and (e) removing the patterned organic photoresist layer from the patterned inorganic resist layer.


Trademark
Ritek Corporation | Date: 2009-09-01

Blank recordable compact discs; blank rewritable compact discs; blank digital versatile recordable discs; blank digital versatile rewritable discs; blank digital versatile discs with random access memory; blank mini digital versatile discs; blank high definition digital video discs; blank optical and magneto-optical discs; flash memory cards; flash memory card readers; flash memory card adapters; USB drives; computer storage devices, namely, flash drives and hard disk drives; MP3 players; MP4 players; digital audio-video receivers; apparatus for converting electronic radiation to electrical energy, namely, poly-crystalline solar modules and mono-crystalline solar modules; photovoltaic solar modules, which is a packaged interconnected assembly of photovoltaic solar cells; solar cells; fuel cells; photovoltaic solar power charger for batteries; photovoltaic solar power system, namely, power system composed of photovoltaic solar modules, batteries, controllers and inverters. Mobile lighting fixtures powered by wind or solar energy; fixed lighting fixtures powered by wind or solar energy; energy saving lamps; LED (light-emitting diode) lighting fixtures; high intensive discharge lighting fixtures.


Patent
Ritek Corporation | Date: 2011-01-14

Disclosed herein is a method for manufacturing a master plate of an optical disc. The method comprises the step of: (a) forming an inorganic resist layer on a substrate; (b) forming an organic photoresist layer on and in contact with the inorganic resist layer; (c) irradiating both the organic photoresist layer and the inorganic resist layer with a laser beam to form a first exposed region of the inorganic resist layer and a second exposed region of the organic photoresist layer; (d) removing the inorganic resist layer of the first exposed region and the organic photoresist layer of the second exposed region; (e) removing the patterned organic photoresist layer from the patterned inorganic resist layer; (f) conformally forming a release layer to cover the patterned inorganic resist layer; (g) plating a metal layer on the release layer; and (h) separating the metal layer and the release layer.

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