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Salt Lake City, UT, United States

Merrill D.R.,Ripple, Llc
Current Opinion in Solid State and Materials Science | Year: 2014

Implantable devices for recording and stimulation of the human nervous system offer promise for the treatment of disorders including spinal cord injury, stroke, traumatic brain injury, sensory and motor deficits, chronic pain, epilepsy, Parkinson's disease and amputation. While advances in neuroengineering devices have been impressive, often the expectations and desires for a chronically implantable device remain unrealized. In the face of engineering approaches which perform well on the bench or in acute implantations is an immune response which is well-tuned to recognize foreign bodies, including the materials chosen for our innovations. Recent years have demonstrated a co-evolution of engineering solutions for neural disorders and knowledge of underlying biological hurdles. This review describes the state-of-the-art for implantable neuroengineering devices used for electrical recording and stimulation, the tissue response to these devices, and emerging technologies and materials to mitigate the tissue response. The test methods for candidate materials and paths to the commercial market are briefly described. © 2014 Elsevier Ltd.

Ripple, Llc | Date: 2014-05-19

This disclosure relates to a systems and methods for control of external devices, such as a prosthesis, using biopotential signals from electrodes in communication with existing muscles or nerves of a patient. More specifically, but not exclusively, this disclosure relates to systems that include wireless transmission of biopotential signals and a multichannel bioamplifier configured to receive biopoential signals. The system may also be configured to stimulate excitable tissue within the body.

Disclosed herein are various embodiments of electrical stimulation systems configured to stimulate tissue in a subject. The system may include a controller configured to send at least one stimulation pattern to be implemented by the electrical stimulation system. The controller may include a first digital control interface. The system may also include a stimulation module that includes a second digital control interface configured to be in electrical communication with the first digital control interface. The stimulation circuitry may be configured to implement the at least one stimulation pattern as an analog stimulation signal based on an ongoing stream of digital commands received from the controller. The system may further comprise a percutaneous connector assembly configured to be coupled to a subject through the subjects skin. The percutaneous connector may include a second connector configured to couple to the first connector and a first electrode lead.

Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 1.88M | Year: 2008

DESCRIPTION (provided by applicant): In this translational SBIR program, we will develop a totally implantable, wireless, subdural electrode grid for short-term cortical EEG monitoring (less than 30 days). This device will be based upon novel manufacturin g processes that will allow synthesis of the wireless implants with integrated electronics at low cost and prices that are competitive with existing wired grids. The availability of this fully implanted subdural grid will substantially reduce hospitalizati on costs and infection rates associated with cortical EEG monitoring procedures. PUBILC HEALTH RELEVANCE: Surgical intervention is an expensive, time intensive, underutilized technique to treat epilepsy, with less than 5% of the potentially aided patient population being treated in this way. A fully implanted wireless device will reduce infection rates and require a less stringent care environment, while cheaper devices and care methods will help to reduce health care costs and increase potential treatment populations. This will enable clinicians to use less expensive treatment options and to move epilepsy monitoring procedures out of expensive Neurology Intensive Care Units.

Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 449.73K | Year: 2011

DESCRIPTION (provided by applicant): The goal of this translational SBIR program is to create a small, implantable system for recording myoelectric signals from residual and reinnervated muscles of individuals with forearm and other amputations. The signals will be wirelessly coupled to an external receiver for controlling prostheses. Compared to conventional surface electrodes, this system will provide: 7 more channels for prosthesis control from a larger number of muscles in the residual limb, 7 improved specificity and repeatability for recording from individual muscles and muscle groups, 7 higher reliability and quality for the recorded signals under different socket conditions, 7 selective, consistent signals from deep muscles, especially in targeted reinnervation users, and 7 the ability to use gel, vacuum, and other prosthesis socket lining systems that do not easily accommodate surface electrodes. These multichannel recordings will also enable users to generate simultaneous multi-axis movementswith a more natural feel of control than existing myocontrollers that only actuate a single joint axis at a time. In Phase I, we will conduct a proof-of-concept animal study to validate the electrode and electronics design. We will compare the wireless multichannel EMG signals transmitted by an implanted prototype system to a standard percutaneous EMG wired system in canines during treadmill walking. In Phase II, we will complete the development of the implant, the external components, and the associated packaging for sterilization. At the end of the Phase II program, the system will be submitted for an IDE for a pilot clinical study in a small population of forearm amputees in Phase III. PUBLIC HEALTH RELEVANCE: The implantable myoelectric sensor produced in this program will provide fundamental improvements in the usability and reliability of prosthetic arms, wrists, and hands. The multi-channel recordings provided by the system will also enable prostheses to produce coordinated, multi-joint movements with a more intuitive, natural feel of control for the user. In the long term, this technology may also help improve outcomes for pediatric prosthesis users by enabling systems that are simpler to learn during critical neurological development periods.

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