Newton, KS, United States
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PubMed | Riordan Clinic
Type: | Journal: The American journal of case reports | Year: 2016

BACKGROUND In neurofibromatosis type 1 (NF1) disease, the loss of the tumor suppressor function of the neurofibromin gene leads to proliferation of neural tumors. In children, the most frequently identified tumor is the optic pathway glioma. CASE REPORT We describe the case of a 5-year-old child who was diagnosed with NF1 and optic pathway tumor onset at the age of 14 months. Because of the tumor progression, chemotherapy with carboplatin and vincristine was prescribed at this early age and continued for one year. As the progression of disease continued after chemotherapy, the child, at the age of 2.8 years, was started on high-dose intravenous vitamin C (IVC) treatment (7-15 grams per week) for 30 months. After 30 months, the results of IVC treatments demonstrated reduction and stabilization of the tumors in the optic chiasm, hypothalamus, and left optic nerve according to radiographic imaging. The right-sided optic nerve mass seen before IVC treatment disappeared by the end of the treatment. CONCLUSIONS This case highlights the positive effects of treating NF1 glioma with IVC. Additional studies are necessary to evaluate the role of high-dose IVC in glioma treatment.


PubMed | Ponce School of Medicine & Health Sciences, Riordan Clinic. and University of Puerto Rico at San Juan
Type: Journal Article | Journal: Journal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine | Year: 2015

The Chikungunya (CHIKV) fever is a viral disease produced by a single-stranded RNA Alphavirus from the Togaviridae genus. Its transmission occurs only through mosquito vectors, principally Aedes aegypti. It requires a human-mosquito-human transmission cycle. It is associated with severe arthritis/arthralgias, myalgias, high fever, headache, and maculopapular rash. Joint ache appears to be symmetrical. The virus has an incubation period of 2 to 7 days, where the high fever is typically presented. It is followed by arthralgias and myalgias, and rashes, which last for 3 to 5 days. However, the arthralgias can persist for months after the infection, which can contribute to severe arthritis. As of now, no vaccine exists for the virus and no official treatment has been developed aside from standard procedures of the use of acetaminophen (paracetamol), and non-steroidal anti-inflammatory drugs. This is a case report of a 54-year old Hispanic individual that reported left shoulder pain, left knee pain and fever. The symptoms started on a Saturday in September 2014 in middle of the night. The patient was treated with high doses of intravenous vitamin C over two days. The symptoms resolved after the infusions without any side effects. Based on the positive outcome in this case, we propose that intravenous vitamin C should be studied further as a potential treatment for acute viral infections.


News Article | November 15, 2016
Site: www.prweb.com

After undergoing failed chemotherapy treatments and the debilitating side effects that go along with them, things are finally looking up for 6 year-old cancer patient, Hoyt Lee. Since starting high-dose intravenous vitamin C therapy at the Riordan Clinic in Wichita, Kansas two and a half years ago, Hoyt’s condition stabilized and is now improving; something his oncologists said would likely never happen. At just three months of age, doctors diagnosed Hoyt Lee with Neurofibromatosis 1 (NF-1). At 16 months old, he started chemotherapy for a brain tumor. After completing a grueling year of drug cocktails that wracked his young body, Hoyt’s mother, Shawna Overbey, received the news that she’d feared the most. Hoyt’s tumors were not responding to the chemo. They were growing. Magnetic Resonance Imaging (MRI) showed accelerated tumor growth in his optic nerve chiasm. The optic chiasm is an X-shaped structure formed by the crossing of the optic nerves in the brain. The tumor was affecting his right and left eyes, his pituitary gland, and his hypothalamus. The only available treatment alternatives were radiation or a different chemotherapy cocktail that can cause nerve damage and affect motor skills like walking and hand movement. That’s when Shawna knew there had to be another way. Countless hours of research lead Shawna and Hoyt to Dr. Ron Hunninghake at the Riordan Clinic, a non-profit organization in Wichita, Kansas that specializes in alternative cancer therapies. The Riordan Clinic was founded in 1975 by Dr. Hugh Riordan and benefactor Olive W. Garvey. It has been providing IV therapy to patients like Hoyt for the past 40 years. The late Dr. Riordan and his son, Neil H. Riordan, PhD, were pioneers in the use of vitamin C to treat cancer. Far ahead of their time, they invented patents (6,448,287, 6,436,411, 6,284,786) on treating cancer with vitamin C that date back prior to the turn of this century. For the past 20 years, Nina Mikirova, PhD has carried on their cancer research at the clinic. Since undergoing IV high-dose vitamin C therapy, Hoyt Lee’s progress has been miraculous. According to his mother, MRIs have shown tumor stability or shrinkage over the past two and a half years. The tumor is no longer affecting his right eye, pituitary gland or hypothalamus. As of February 2016, there is almost no sign of a tumor in Hoyt’s optic nerve chiasm. Hoyt is doing so well that he won’t have to return to the hospital for another year. “We are delighted with Hoyt’s progress and equally proud that through generous charitable contributions, we’ve been able to do it without the crushing costs that can be associated with conventional treatments like chemotherapy,” commented Donna Kramme, CEO of Riordan Clinic. “It can cost as much as $15,000 per year to treat a child like Hoyt. We ask that everyone who is passionate about helping children like Hoyt please contact the Riordan Clinic to donate today. Without your help we cannot continue vital research that will make Hugh Riordan’s dream four decades ago, a reality today and into the future,” she concluded. “As Schopenhauer said, ‘All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident.’,” said Dr. Riordan. “As far as high-dose vitamin C goes, I think that, fortunately, we are finally entering the third stage,’ he added. No longer working at the Riordan Clinic in Wichita, Dr. Riordan is now a renowned applied stem cell therapy researcher whose clinic in Panama, Stem Cell Institute, specializes in treating inflammatory and autoimmune related conditions with human *umbilical cord tissue–derived mesenchymal stem cells. Dr. Riordan has also teamed up with board-certified orthopedic surgeon, Wade McKenna, DO to bring stem cell therapy for orthopedic conditions to Southlake, Texas at the Riordan-McKenna Institute (RMI). RMI uses a proprietary mixture of the patient’s own bone marrow stem cells with *amniotic tissue products. Patients can receive intravenous high-dose vitamin C and other intravenous nutritional supplements at Riordan Wellness, which occupies space at the RMI building in Southlake. Riordan Clinic is a not-for-profit 501(c)(3), nutrition-based health facility in Wichita, Kansas. We have integrated lifestyle and nutrition to help you find the underlying causes of your illness. Since our inception in 1975, our mission has been clear and unwavering. Our functional medicine providers “stimulate an epidemic of health.” People turn to the Riordan Clinic to restore, improve, and maintain health. Our integrative health practitioners listen to the needs of patients. Then we test and measure to map out a research-based, nutrition-fueled path to well being. Together, our professionals move beyond simply treating symptoms to address illness at its cause. Your Way to Well communicates a positive, hope-filled message. It stresses our individualized approach and achieves the best possible outcomes. RMI specializes in non-surgical treatment of acute and chronic orthopedic conditions using *amniotic tissue allograft and bone marrow aspirate concentrate (BMAC) that is harvested using the patented BioMAC bone marrow aspiration cannula. Common conditions treated include meniscal tears, ACL injuries, rotator cuff injuries, runner’s knee, tennis elbow, and joint pain due to degenerative conditions like osteoarthritis. Additionally, RMI augments orthopedic surgeries with BMAC and amniotic tissue allograft to promote better post-surgical outcomes and uses amniotic membranes as part of a complete wound care treatment regimen. BMAC contains a patient’s own mesenchymal stem cells (MSC,) hematopoietic stem cells (CD34+), growth factors and other progenitor cells. Amniotic tissue allograft is composed of collagens and other structural proteins, which provide a biologic matrix that supports angiogenesis, tissue growth and new collagen during tissue regeneration and repair. Founded in 2007 on the principles of providing unbiased, scientifically sound treatment options; the Stem Cell Institute (SCI) has matured into the world’s leading adult stem cell therapy and research center. In close collaboration with universities and physicians world-wide, our comprehensive stem cell treatment protocols employ well-targeted combinations of autologous bone marrow stem cells, autologous adipose stem cells, and donor human umbilical cord stem cells to treat: autism, cerebral palsy, multiple sclerosis, spinal cord injury, osteoarthritis, rheumatoid arthritis, heart disease, and autoimmune diseases. In partnership with Translational Biosciences, a subsidiary of Medistem Panama, SCI provides clinical services for ongoing clinical trials that are assessing safety and signs of efficacy for autism, multiple sclerosis, osteoarthritis, rheumatoid arthritis, and spinal cord injury using allogeneic umbilical cord tissue-derived mesenchymal stem cells (hUC-MSC) and hU-MSC-derived mesenchymal trophic factors (MTF). In 2017, Translation Biosciences plans to expand its clinical trial portfolio to include heart disease and cerebral palsy. For more information on stem cell therapy:


Mikirova N.,Riordan Clinic | Casciari J.,Riordan Clinic | Rogers A.,Riordan Clinic | Taylor P.,Riordan Clinic
Journal of Translational Medicine | Year: 2012

Background: An inflammatory component is present in the microenvironment of most neoplastic tissues. Inflammation and elevated C-reactive protein (CRP) are associated with poor prognosis and decreased survival in many types of cancer.Vitamin C has been suggested as having both a preventative and therapeutic role in a number of pathologies when administered at much higher-than-recommended dietary allowance levels.Since in vitro studies demonstrated inhibition of pro-inflammatory pathways by millimolar concentrations of vitamin C, we decided to analyze the effects of high dose IVC therapy in suppression of inflammation in cancer patients.Methods: 45 patients with prostate cancer, breast cancer, bladder cancer, pancreatic cancer, lung cancer, thyroid cancer, skin cancer and B-cell lymphoma were treated at the Riordan Clinic by high doses of vitamin C (7.5 g -50 g) after standard treatments by conventional methods.CRP and tumor markers were measured in serum or heparin-plasma as a routine analysis. In addition, serum samples were collected before and after the IVCs for the cytokine kit tests.Results: According to our data positive response to treatment, which was demonstrated by measurements of C- reactive protein, was found in 75% of patients and progression of the inflammation in 25% of patients. IVC treatments on all aggressive stage cancer patients showed the poor response of treatment.There was correlation between tumor markers (PSA, CEA, CA27.29 and CA15-3) and changes in the levels of C-reactive protein.Our test of the effect of IVC on pro-inflammatory cytokines demonstrated that inflammation cytokines IL-1α, IL-2, IL-8, TNF-α, chemokine eotaxin and CRP were reduced significantly after treatments.Conclusions: The high dose intravenous ascorbic acid therapy affects C-reactive protein levels and pro-inflammation cytokines in cancer patients. In our study, we found that modulation of inflammation by IVC correlated with decreases in tumor marker levels.In summary, our data support the hypothesis that high dose intravenous ascorbate treatments may reduce inflammation in cancer patients. Our results suggest that further investigations into the use of IVC to reduce inflammation in diseases where inflammation is relevant are warranted. © 2012 Mikirova et al.; licensee BioMed Central Ltd.


Mikirova N.A.,Riordan Clinic | Casciari J.J.,Riordan Clinic | Hunninghake R.E.,Riordan Clinic
Journal of Orthomolecular Medicine | Year: 2013

Background: Attention deficit hyperactivity disorder (ADHD) is characterized by atypically severe inattentiveness, hyperactivity, and impulsiveness. While its cause is unknown, biological and environmental influences are likely. Objectives: To identify the metabolic imbalances in fatty acid, amino acid, mineral, and pyrrole levels in ADHD patients, and to examine the effectiveness of the nutritional approach in the correction of these imbalances in an outpatient clinic. Design: Medical records of 116 patients with ADHD treated with nutritional approaches were retrospectively reviewed. Demographics were limited to ensure confidentiality. Blood levels of fatty acids, amino acids, vitamins and minerals, hair analysis of heavy metals and urine pyrrole levels were done on all patients. Comparisons with control (i.e., normal values) were made. Improvements following nutritional interventions were measured and compared to controls. Setting: The Riordan Clinic (Wichita, KS), an outpatient complementary and alternative medical clinic. Intervention: Various nutritional interventions (i.e., minerals, vitamins, omega-3 and omega-6 essential fatty acids, flavonoids, probiotics, dietary modifications and chelation of toxic metals by natural substances) were prescribed based on laboratory results. Main Outcome Measures: Serum fatty acid composition, measurements of minerals (normal and toxic) in hair and, in some cases, in red blood cells (RBC), and assessments of vitamins in serum and pyrroles in urine. Results: There was a predominance of below-normal docosahexaenoic acid, eicosapentaenoic acid, and gamma-linolenic acid levels; a high incidence of unfavorable arachidonic acid-to-eicosapentaenoic acid and omega-6-to-omega-3 ratios; deficiencies in zinc, magnesium, and selenium levels; and the presence of toxic metals in above-normal amounts. Conclusions: Our data suggests that at least two of the factors that were the most abnormal, omega-6-to-omega-3 ratios and pyrrole levels, and can in fact improve in subjects undergoing a regimen with nutrient supplementation. While nutritional manipulation did result in improved metabolic profiles in our sample, these results warrant a study of a larger sample, with an attempt to document whether these changes have an effect on improving behavior and cognition in the form of a prospective, controlled clinical study.


Background: Psychiatrists started using urine pyrroles (hydroxyhemopyrrolin-2-one, HPL) to diagnose psychiatric disorders many years ago. The biological origins of HPL are not known, nor are the causes of elevated urinary pyrrole excretion well understood. Methods: In the present study we analyzed the level of pyrroles in 148 patients with schizophrenia, 135 patients with bipolar disorder, 97 patients with depression, 119 patients with attention deficit hyperactivity disorder, and compared these data with the results of pyrrole tests for patients with non-psychiatric conditions and healthy volunteers. Results: According to our data, urinary pyrrole concentrations tended to be high in patients with psychiatric disorders, but elevated level of pyrroles was not specific for only these patients. We found evidence of an allergy related component in the fact that elevated pyrrole levels were significantly more prevalent in subjects with elevated histamine values. A role of intestinal bacteria, or imbalances in intestinal bacterial metabolism, was also suggested based on the found relationship between elevated pyrrole levels and elevations in indicans and urobilinogens. In addition, our data demonstrated that subjects with severely elevated pyrrole levels were deficient in nutrients such as zinc, Vitamin B3, and Vitamin C. Conclusion: Thus, pyrrole excretion seems to be a component of illness in general and not strictly psychiatric disorders.


Mikirova N.,Riordan Clinic | Casciari J.,Riordan Clinic | Hunninghake R.,Riordan Clinic
Alternative Therapies in Health and Medicine | Year: 2012

Context: Chronic fatigue syndrome (CFS) is a debilitating fatigue illness that has unknown etiology and lacks an objective diagnostic marker. Objective: To examine the metabolic component of CFS to determine if practitioners can use serum NAD(P)H concentration measurements to monitor metabolism and fatigue status in patients with CFS. Design: The research team conducted a case-control study, comparing a group of patients who were diagnosed with CFS with a control group of healthy subjects. The team obtained venous blood samples from fasting patients to examine the serum NAD(P)H concentrations. Setting: The study occurred at the Riordan Clinic in Witchita, Kansas. Participants: The study included 44 CFS patients at the Riordan Clinic and 30 healthy control participants. The CFS patients presented a spectrum of symptoms that had existed for at least 6 months: new, unexplained, persistent, or relapsing chronic fatigue that bed rest did not resolve and that was severe enough to reduce daily activity significantly-by 50%-in conjunction with headache, muscle pain, pain in multiple joints, and unrefreshing sleep. In the control group, the research team enrolled subjects without diagnosis of disease or injury. Outcome Measures: The research team determined levels of serum reduced nicotinamide adenine dinucleotides (NADH and NAD[P]H) by measuring serum fluorescence emission at 450 nm. The team then conducted sensitivity and specificity analyses. Results: NAD(P)H concentrations in serum of CFS participants averaged 8.0 ± 1.4 (standard deviation [SD]) nmol/mL, while those in the healthy controls averaged 10.8 ± 0.8 (SD) nmol/mL, a statistically significant difference. Using a cut-off concentration of 9.5 nmol/mL, the research team attained a sensitivity of 0.73 and a specificity of 1.0. An analysis of receiver- operator characteristics yielded an area under the curve of 0.9. The research team compared serum NAD(P)H to several endocrine and metabolic lab parameters. Serum NAD(P)H was directly correlated with serum CoQ10 levels and inversely correlated with urine hydroxyhemopyrrolin-2-one levels. Conclusions: Based on these findings, the research team proposed using serum NAD(P)H, measured as an intrinsic serumfluorescence emission, to monitor metabolism and fatigue status in patients with CFS. Following patients' NAD(P)H levels over time may aid in selecting therapeutic strategies and monitoring treatment outcomes.


Mikirova N.,Riordan Clinic | Casciari J.,Riordan Clinic | Riordan N.,Riordan Clinic | Hunninghake R.,Riordan Clinic
Journal of Translational Medicine | Year: 2013

Background: Ascorbic acid (vitamin C, ascorbate) is a key water soluble antioxidant that, when administered in doses well above its recommended dietary allowance, may have preventative and therapeutic value against a number of pathologies. The intravenous administration of high dose ascorbate (IVC) has increased in popularity among complementary and alternative medicine practitioners: thousands of patients received IVC, at an average dose of 0.5 g/kg, without significant side effects. While IVC may have a variety of possible applications, it has generated the most interest for its potential use in treating cancer.Methods: Medical records of patients with cancer treated with IVC at the Riordan Clinic were retrospectively reviewed. Cancer patients, for whom plasma ascorbate concentration data before and after treatment were available, along with C-reactive protein (CRP) measurements, were chosen for analysis.Results: The results of the analysis can be summarized as follows. IVC produces peak plasma ascorbate concentrations on the order of ten millimolars with lower peak plasma concentrations obtained in cancer patients as compared to healthy subjects. Cancer patients who are deficient in vitamin C prior to therapy tend to achieve lower plasma levels post infusion. High inflammation or tumor burdens, as measured by CRP or tumor antigen levels, tend to lower peak plasma ascorbate levels after IVC. When compared to patients with localized tumors, patients with metastatic tumors tend to achieve lower post infusion plasma ascorbate concentrations.Conclusions: The data indicate that, while potentially therapeutic plasma ascorbate concentrations can be achieved with IVC, levels attained will vary based on tumor burden and degree of inflammation (among other factors). Evidence suggests that IVC may be able to modulate inflammation, which in turn might improve outcomes for cancer patients. IVC may serve as a safe, adjunctive therapy in clinical cancer care. © 2013 Mikirova et al.; licensee BioMed Central Ltd.


Mikirova N.,Riordan Clinic | Casciari J.,Riordan Clinic | Hunninghake R.,Riordan Clinic
Translational Biomedicine | Year: 2011

Metal toxicity represents a significant public health concern and contributes to many toxic metal-exposure related diseases. In particular, toxic metals promote the oxidative stress in stem cells and endothelial progenitor cells (EPCs). EPCs that are presented in peripheral blood function to replenish aging damaged endothelial cells and play important role in the maintenance of vasculature and neovascularization. Given the links between oxidative injury, endothelial cell dysfunction and vascular disease, we focused our investigation on the response of CD34-positive cells to chelation by DMSA. In addition, we compared the effectiveness of DMSA and EDTA in the chelation of toxic metals and the excretion of essential metals. The data were compared for 160 subjects after oral DMSA (500mg) chelation and 250 subjects after intravenous EDTA (1g-3g) chelation. Our in vitro experiments were designed to compare the intrinsic toxicity of two antidotes and their effectiveness in lead chelation. One of the important results of our study shows that the removal of toxic metals improves the number of stem/progenitor cells in circulation. After a series of five DMSA treatments, the number of CD34+ cells in circulation was increased on 50%-160% (p<0.05). Our in vitro experiments demonstrated that toxic metals (lead and mercury) inhibit mesenchymal stem cell metabolism and proliferation, and that stem cells are more sensitive to these metals than differentiated cells. In comparison with EDTA, DMSA was more effective in the extraction of lead, but treatment by this antidote resulted in a very high excretion of copper (55 folds). Clearance of essential metals during chelation by 1g-3g of EDTA was increased over twenty-fold for zinc and manganese. In summary, we suggest that chelation therapy shows promise in repairing metal toxicity damage and restoring circulating stem cells. © Under License of Creative Commons Attribution 3.0 License.


PubMed | Riordan Clinic
Type: Evaluation Studies | Journal: Alternative therapies in health and medicine | Year: 2012

Chronic fatigue syndrome (CFS) is a debilitating fatigue illness that has unknown etiology and lacks an objective diagnostic marker.To examine the metabolic component of CFS to determine if practitioners can use serum NAD(P)H concentration measurements to monitor metabolism and fatigue status in patients with CFS.The research team conducted a case-control study, comparing a group of patients who were diagnosed with CFS with a control group of healthy subjects. The team obtained venous blood samples from fasting patients to examine the serum NAD(P)H concentrations.The study occurred at the Riordan Clinic in Witchita, Kansas.The study included 44 CFS patients at the Riordan Clinic and 30 healthy control participants. The CFS patients presented a spectrum of symptoms that had existed for at least 6 months: new, unexplained, persistent, or relapsing chronic fatigue that bed rest did not resolve and that was severe enough to reduce daily activity significantly by 50% in conjunction with headache, muscle pain, pain in multiple joints, and unrefreshing sleep. In the control group, the research team enrolled subjects without diagnosis of disease or injury.The research team determined levels of serum reduced nicotinamide adenine dinucleotides (NADH and NAD[P]H) by measuring serum fluorescence emission at 450 nm. The team then conducted sensitivity and specificity analyses. Results NAD(P)H concentrations in serum of CFS participants averaged 8.0 1.4 (standard deviation [SD]) nmol/mL, while those in the healthy controls averaged 10.8 0.8 (SD) nmol/mL, a statistically significant difference. Using a cut-off concentration of 9.5 nmol/mL, the research team attained a sensitivity of 0.73 and a specificity of 1.0. An analysis of receiver-operator characteristics yielded an area under the curve of 0.9. The research team compared serum NAD(P)H to several endocrine and metabolic lab parameters. Serum NAD(P)H was directly correlated with serum CoQ10 levels and inversely correlated with urine hydroxyhemopyrrolin-2-one levels.Based on these findings, the research team proposed using serum NAD(P)H, measured as an intrinsic serum-fluorescence emission, to monitor metabolism and fatigue status in patients with CFS. Following patients NAD(P)H levels over time may aid in selecting therapeutic strategies and monitoring treatment outcomes.

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