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Sahlman J.,Kuopio University Hospital | Miettinen K.,Kuopio University Hospital | Peuhkurinen K.,Kuopio University Hospital | Seppa J.,Kuopio University Hospital | And 9 more authors.
Journal of Sleep Research | Year: 2010

It is widely accepted that obstructive sleep apnoea (OSA) is linked with cardiovascular diseases. The relationship is complex and remains still poorly understood. The presence of chronic systemic inflammation has been connected with pathogenesis of both OSA and cardiovascular diseases. While atherogenesis is believed to be a process of many years, little is known about the potential impact of the largest OSA subgroup, mild OSA, on the development of cardiovascular diseases. The aim of the present study was to assess whether untreated mild OSA is associated with an activation of inflammatory cytokine system. The adult study population consisted of two groups: 84 patients with mild OSA [apnoea-hypopnoea index (AHI) 5-15 h-1] and 40 controls (AHI <5 h-1). Serum concentrations of pro- and anti-inflammatory cytokines were measured before any interventions. After adjustments for age, sex, body mass index, fat percentage, most important cardiometabolic and inflammatory diseases, and non-steroidal anti-inflammatory medication, the mean level of tumour necrosis factor-α was significantly elevated (1.54 versus 1.17 pg mL-1, P = 0.004), whereas the level of interleukin-1β (IL-1β) was reduced (0.19 versus 0.23 pg mL-1, P = 0.004) in patients with mild OSA compared with controls. The concentrations of the protective anti-inflammatory cytokines, interleukin-10 (1.28 versus 0.70 pg mL-1, P < 0.001) and interleukin-1 receptor antagonist (478 versus 330 pg mL-1, P = 0.003) were elevated in the OSA group. The concentrations of C-reactive protein increased, but IL-1β decreased along with the increase of AHI. Mild OSA was found to be associated not only with the activation of the pro-inflammatory, but also with the anti-inflammatory systems. © 2009 European Sleep Research Society. Source


Atroshi F.,University of Helsinki | Tallberg T.,Helsinki Institute for Bio Immunotherapy | Westermarck T.,Rinnekoti Research Center
Trace Elements and Electrolytes | Year: 2010

One of the main endeavors in cancer therapy is to prevent recurrent disease. Surgery and toxic treatment modalities have only invasively removed the symptoms of the etiological longstanding metabolic deficiency actually leading to cancer, but therapy has not tried to intervene with the etiology, and therefore the disease may recur. A healthy diet is perhaps the most important lifestyle change a person can make to help prevent diseases such as cardiovascular disease, diabetes and possibly cancer. Dietary supplements include vitamins, minerals, herbs or other botanicals, amino acids, and other substances intended to supplement the diet. By correcting the actual causative metabolic deficiency, recurrent disease can be postponed, the disease-free interval be prolonged and patients' health preserved for decades. Good clinical results have been obtained with patients suffering from renal cell carcinoma, malignant melanoma, and prostate cancer. We use a specific ready-made product containing all the pertinent dietary supplementary natural factors needed to treat and possibly prevent recurrent disease in these different forms of cancer, as well as breast cancer. The treatment is so economical because the therapy includes only natural metabolic factors. This biological treatment is thus also in principle ethical. Furthermore bio-immunotherapy entails no side-effects. ©2010 Dustri-Verlag Dr. K. Feistle. Source


Heikkila K.,University of Helsinki | Vuoksimaa E.,University of Helsinki | Oksava K.,University of Helsinki | Saari-Kemppainen A.,University of Helsinki | And 2 more authors.
Ultrasound in Obstetrics and Gynecology | Year: 2011

Objectives To determine whether exposure to prenatal ultrasound increases non-right-handedness in boys. Methods The association between exposure to prenatal ultrasound and handedness was tested, using logistic regression analysis, in the Helsinki Ultrasound Trial data. We applied an intention-to-treat approach in this analysis of a subset of 4150 subjects whose parents answered a follow-up questionnaire on handedness when the children were aged 13-15 years. Results The odds ratio for non-right-handedness of children who had been exposed to prenatal ultrasound was 1.16 (0.98-1.37) for all subjects, 1.12 (0.89-1.41) for boys and 1.24 (0.97-1.58) for girls. Conclusions We could not confirm the hypothesis that prenatal ultrasound exposure and handedness are associated. Our findings were independent of the particular definition of handedness used, whether it was considered according to the writing hand alone or defined using a laterality quotient. © 2011 ISUOG. Published by John Wiley & Sons, Ltd. Source


Leger D.,University of Paris Descartes | Partinen M.,Rinnekoti Research Center | Hirshkowitz M.,Sleep Disorders and Research Center | Chokroverty S.,New Jersey Neuroscience Institute | And 2 more authors.
Sleep Medicine | Year: 2010

Objective: To assess the daytime consequences in outpatients suffering from different insomnia symptoms in primary care practice. Methods: An international cross-sectional survey was conducted in 5293 outpatients complaining of sleep disturbances in primary care practice. A sleep questionnaire addressing daytime consequences, insomnia symptoms, socio-demographic characteristics, and other sleep variables was administered by 647 physicians in 10 countries. Results: Overall, 20-33% of subjects reported " severe" daytime impairments associated with sleep disturbances. Approximately 45% of patients complaining of sleep disturbances in primary care practice suffered from a combination of insomnia symptoms. Patients suffering from all insomnia symptoms reported the most severe daytime functioning impairments compared with patients suffering from initiation or maintenance insomnia only. Conversely, the majority of patients suffering from non-restorative sleep reported little daytime functioning impairments compared to the patients suffering from other combinations of insomnia symptoms. The strongest risk factor associated with " severe" daytime functioning impairments was sleep quality perception. Conclusions: Primary insomnia disturbs subjective daytime functioning. A report of combined insomnia symptoms reflected the most damaging insomnia subtype and had a negative impact on a wide range of daytime functioning consequences. © 2010 Elsevier B.V. Source


Plonka-Poltorak E.,Antiepileptic Outpatient Clinic | Zagrodzki P.,Jagiellonian University | Zagrodzki P.,Henryk Niewodniczanski Institute of Nuclear Physics | Chlopicka J.,Jagiellonian University | And 5 more authors.
Biological Trace Element Research | Year: 2011

We aimed to evaluate changes in antioxidant status in blood during valproate (VPA) monotherapy of adult patients with epilepsy. Antioxidant enzymes [plasma superoxide dismutase (pSOD), erythrocyte superoxide dismutase (eSOD)] and non-enzymatic indices [concentration of trace elements in serum: selenium, copper, zinc (sZn) and uric acid (UA), as well as the ferric reducing ability of plasma (FRAP) and UA-independent FRAP (UAiFRAP)] were evaluated in 21 adult patients with epilepsy and 21 healthy controls. Significant differences between the study group and controls were found for pSOD (p = 0.002) and UAiFRAP (p = 0.003). pSOD was higher, whilst UAiFRAP was lower in patients compared to controls. The activity of eSOD was higher in patients treated with VPA for a longer period (7-14 years) in comparison to controls (p = 0.001) and patients with a short period of VPA treatment (p < 0.001). Patients with uncontrolled epilepsy exhibited higher sZn than seizure-free patients (p = 0.041). Standard diet and moderate use of alcohol and/or nicotine did not exert significant effects on redox balance. We conclude that the antioxidant status of epileptic patients is modified by valproate monotherapy. The frequency of seizures and duration of VPA therapy are associated with changes of oxidative/antioxidative balance. The most sensitive and relevant parameters for antioxidative defence mechanism are pSOD, UAiFRAP and sZn. © 2011 Springer Science+Business Media, LLC. Source

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