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Niino H.,ITO EN Ltd | Sagesaka Y.,ITO EN Ltd | Sakurai Y.,ITO EN Ltd | Sakoda T.,Rinku Medical General Center | Enomoto T.,A+ Network
Japanese Pharmacology and Therapeutics | Year: 2012

Background: The incidence of seasonal allergic rhinoconjunctivitis triggered by cedar pollen (herewith referred to as cedar pollinosis) continues to increase in Japan, affecting 26.5% of the Japanese population. We evaluated a soft drink containing Enterococcus faecalis EC-12 with respect to its antiallergic effect on patients with cedar pollinosis. This study was performed using an environmental exposure unit (EEU), which assists in the development of effective therapeutic and preventive measures. Methods: We recruited 20 patients with cedar pollinosis over a period of 2 years. We administered 200 mL of a drink containing EC-12 daily, for 8 weeks during the offseason for cedar pollen dispersion. The patients were exposed to pollen before and after the intake of the EC-12 drink to examine the subjective symptoms in the pollen exposure room and those during 5 days after the exposure. Results: In the EEU, (a) nasal discharge and (b) itchy eyes decreased significantly after the intake of the EC-12 drink (a ; p=0.041 at 90 min, b ; p=0.034 at 120 min, p=0.038 at 150 min). Nasal obstruction and scratchy throat seemed to improve, and the amount of tears produced seemed to decrease. During 5 days after the exposure, the patients showed a significant difference in the following parameters : (c) disturbance in daily living activities, (d) itchiness of the eyes, (e) the amount of tears produced, and (f) drowsiness (c ; p=0.037 on the night of the exposure, d ; p=0.031 at Day 1, e ; p =0.039 on the night of the exposure, f ; p=0.048 on the night of the exposure, p = 0.044 at Day 4). Sneezing fits and nasal obstruction seemed to improve. The mucous membrane swelling of the inferior concha on pollen exposure significantly improved after the intake of the drink (p=0.0007). Conclusions: These results imply that continuing the intake of the EC-12 drink may alleviate symptoms and improve the quality of life in patients with cedar pollinosis.

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