Saitama, Japan
Saitama, Japan

RIKEN is a large research institute in Japan. Founded in 1917, it now has approximately 3000 scientists on seven campuses across Japan, the main one in Wako, just outside Tokyo. RIKEN is an Independent Administrative Institution whose formal name in Japanese is Rikagaku Kenkyūsho .RIKEN conducts research in many areas of science, including physics, chemistry, biology, medical science, engineering and computational science, and ranging from basic research to practical applications. It is almost entirely funded by the Japanese government, and its annual budget is approximately ¥88 billion . Wikipedia.

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Patent
Riken | Date: 2017-05-17

A compression ring that makes it possible to suppress adhesion of a piston material to the compression ring is provided. The compression ring 11 includes an annular main body 12 that is constituted of a steel material consisting of 0.45 to 0.55 mass% of C, 0.15 to 0.35 mass% of Si, 0.65 to 0.95 mass% of Mn, 0.80 to 1.10 mass% of Cr, 0.25 mass% or less of V, less than 0.010 mass% of P, and a balance containing Fe and an inevitable impurity.


Patent
Riken, University of Tokyo and School Corporation | Date: 2017-02-15

Strains of human-derived bacteria have been obtained from complex fecal samples and shown to induce accumulation of Th17 cells in the intestine and promote immune functions. Pharmaceutical compositions containing these bacteria can be used as anti-infectives and as adjuvants in mucosal vaccines.


Patent
Riken | Date: 2017-03-15

A sliding member 1 according to one aspect of the present invention includes a base material 2 and a thermal spray coating 10 formed on a sliding surface of the base material 2, wherein the thermal spray coating 10 includes a molybdenum phase 11, a chromium carbide phase 12 and a nickel chromium alloy phase 13; the molybdenum phase 11, the chromium carbide phase 12 and the nickel chromium alloy phase are deposited on the sliding surface of the base material 2; and T_(CrC)/T_(Mo) is 0.46 to 1.00 where the average value of the thickness t_(CrC) of the chromium carbide phases 12 in the direction Y perpendicular to the surface of the base material 2 is T_(CrC), and the average value of the thickness t_(Mo) of the molybdenum phases 11 in the same direction thereof is T_(Mo).


To provide an oil scraper ring for a piston rod having excellent oil-scraping performance to reduce the amount of drain, and a stuffing box comprising such oil scraper rings, a ring body of the oil scraper ring is circumferentially divided to at least two, the ring body comprising a rail at an inner-side longitudinal center, a coil spring groove at an outer-side longitudinal center, and pluralities of oil drain grooves at least one of upper and lower surfaces, which are inclined such that their cross section areas increase as going from the inner side to the outer side.


The present invention relates to an actinic-ray-curable resin composition which comprises: (A) 100 parts by mass of a polyfunctional (meth)acrylate; (B) 0.2-4 parts by mass of a compound having an alkoxysilyl group and a (meth)acryloyl group; (C) 0.05-3 parts by mass of an organic titanium; and (D) 5-100 parts by mass of fine particles having an average particle diameter of 1-300 nm. The present invention also relates to a layered transparent resin product which comprises a hardcoat layer and a layer of a transparent resin sheet in this order from the outermost layer side, wherein the hardcoat has been formed from a coating material comprising:(A) 100 parts by mass of a polyfunctional (meth)acrylate; (B) 0.2-4 parts by mass of a compound having an alkoxysilyl group and a (meth)acryloyl group; (C) 0.05-3 parts by mass of an organic titanium; and (D) 5-100 parts by mass of fine particles having an average particle diameter of 1-300 nm.


Patent
Riken | Date: 2017-01-11

An object of the present invention is to provide a plant transformation method that is convenient and is widely applicable to various types of plant cells and nucleic acids. The present invention relates to a method for transforming a target plant, comprising the steps of:a) contacting a carrier peptide comprising a cell-penetrating sequence and a polycation sequence with a nucleic acid to form a complex; b) contacting the obtained complex with a cell of a meristem of the target plant to transfer the nucleic acid to the genome; c) allowing the meristem to grow; and d) selecting a plant harboring the transferred nucleic acid.


Patent
Riken and Kabushiki Kaisha Dnaform | Date: 2017-02-01

The present invention is intended to provide a novel fluorescent labeled single-stranded nucleic acid, by which the background of an exciton oligomer can be further reduced and the novel use thereof. The present invention relates to a labeled single-stranded nucleic acid having at least two fluorescent atomic group pairs that exhibit an exciton effect. The labeled single-stranded nucleic acid is characterized in that the emission peak wavelength of one of the fluorescent atomic group pairs (fluorescent atomic group pair A) is shorter than the excitation peak wavelength of the other fluorescent atomic group pair (fluorescent atomic group pair B), and the fluorescent atomic group pairs A and B have a Forster resonance energy transfer (FRET) effect. This fluorescent labeled single-stranded nucleic acid is usable as a primer for amplifying a target nucleic acid or a probe to be hybridized with a target nucleic acid.


Patent
Riken, Animal Allergy Clinical Laboratories Inc. and Nippon Zenyaku Kogyo Co. | Date: 2017-04-19

The present invention provides a synthetic peptide capable of inducing an antibody to an autoantigen, and specifically, provides: a multiplexed same type-antigenic peptide comprising a dendritic core and B-cell recognition peptides, wherein the multiplexed same type-antigenic peptide comprises 4 to 8 B-cell recognition peptides of the same type that are bound to the terminal ends of the dendritic core directly or via a spacer, and each B-cell recognition peptide is bound to the terminal end of the dendritic core directly or via a spacer; an antibody production-inducing agent comprising the peptides; and a method for producing the peptide.


Patent
Riken | Date: 2017-04-12

This invention relates to an agent for inducing a callus comprising a compound represented by Formula (I) or a hydrolysis product of an amide bond thereof:^(1) represents phenyl substituted with substituent or substituents selected from alkoxy and methylenedioxy; Ar^(2) represents phenyl substituted with halogen; R^(1) and R^(2) each represent hydrogen, alkyl, cyano, or carboxyl; R^(1) and R^(2) may together form oxo; R^(3) to R^(10) each represent hydrogen or methyl; and R^(3) and R^(4), R^(5) and R^(6), R^(7) and R^(8), and/or R^(9) and R^(10) may together form oxo; a method for inducing a callus and a method for plant transformation using such agent for inducing a callus.


Takeichi M.,RIKEN
Nature Reviews Molecular Cell Biology | Year: 2014

Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape changes, particularly during embryonic development and in equivalent processes in adults. Accumulating evidence suggests that the remodelling of cell junctions, especially adherens junctions (AJs), has major roles in controlling these behaviours. AJs comprise cadherin adhesion receptors and cytoplasmic proteins that associate with them, including catenins and actin filaments, and exhibit various forms, such as linear or punctate. Remodelling of AJs induces epithelial reshaping in various ways, including by planar-polarized apical constriction that is driven by the contraction of AJ-associated actomyosin and that occurs during neural plate bending and germband extension. RHO GTPases and their effectors regulate actin polymerization and actomyosin contraction at AJs during the epithelial reshaping processes. copyright © 2014 Macmillan Publishers Limited.

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