Saitama, Japan
Saitama, Japan

RIKEN is a large research institute in Japan. Founded in 1917, it now has approximately 3000 scientists on seven campuses across Japan, the main one in Wako, just outside Tokyo. RIKEN is an Independent Administrative Institution whose formal name in Japanese is Rikagaku Kenkyūsho .RIKEN conducts research in many areas of science, including physics, chemistry, biology, medical science, engineering and computational science, and ranging from basic research to practical applications. It is almost entirely funded by the Japanese government, and its annual budget is approximately ¥88 billion . Wikipedia.

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Riken | Date: 2016-09-16

A seal member is made of a composite material. The composite material includes: any one of an acrylic elastomer, a hydrogenated nitrile elastomer, a fluorinated elastomer, and a fluorosilicone elastomer as a main component; and a particulate filler and a fibrous filler. The particulate filler has a mean particle diameter of 1.0 m or more and 50 m or less. The fibrous filler has a mean diameter of 5.0 m or more and 20 m or less and has a mean length of 0.1 mm or more and 8 mm or less. Content of the particulate filler is 10% by volume or more and 35% by volume or less, and content of the fibrous filler is 5% by volume or more and 15% by volume or less.

Riken | Date: 2016-08-29

Stem cells such as embryonic stem cells (ES cells), including human ES cells, are cultured in a medium comprising a ROCK inhibitor, and a stem cell culture medium, optionally serum free, comprises a ROCK inhibitor.

To provide an oil scraper ring for a piston rod having excellent oil-scraping performance to reduce the amount of drain, and a stuffing box comprising such oil scraper rings, a ring body of the oil scraper ring is circumferentially divided to at least two, the ring body comprising a rail at an inner-side longitudinal center, a coil spring groove at an outer-side longitudinal center, and pluralities of oil drain grooves at least one of upper and lower surfaces, which are inclined such that their cross section areas increase as going from the inner side to the outer side.

The present invention relates to an actinic-ray-curable resin composition which comprises: (A) 100 parts by mass of a polyfunctional (meth)acrylate; (B) 0.2-4 parts by mass of a compound having an alkoxysilyl group and a (meth)acryloyl group; (C) 0.05-3 parts by mass of an organic titanium; and (D) 5-100 parts by mass of fine particles having an average particle diameter of 1-300 nm. The present invention also relates to a layered transparent resin product which comprises a hardcoat layer and a layer of a transparent resin sheet in this order from the outermost layer side, wherein the hardcoat has been formed from a coating material comprising:(A) 100 parts by mass of a polyfunctional (meth)acrylate; (B) 0.2-4 parts by mass of a compound having an alkoxysilyl group and a (meth)acryloyl group; (C) 0.05-3 parts by mass of an organic titanium; and (D) 5-100 parts by mass of fine particles having an average particle diameter of 1-300 nm.

Riken and Kabushiki Kaisha Dnaform | Date: 2017-02-01

The present invention is intended to provide a novel fluorescent labeled single-stranded nucleic acid, by which the background of an exciton oligomer can be further reduced and the novel use thereof. The present invention relates to a labeled single-stranded nucleic acid having at least two fluorescent atomic group pairs that exhibit an exciton effect. The labeled single-stranded nucleic acid is characterized in that the emission peak wavelength of one of the fluorescent atomic group pairs (fluorescent atomic group pair A) is shorter than the excitation peak wavelength of the other fluorescent atomic group pair (fluorescent atomic group pair B), and the fluorescent atomic group pairs A and B have a Forster resonance energy transfer (FRET) effect. This fluorescent labeled single-stranded nucleic acid is usable as a primer for amplifying a target nucleic acid or a probe to be hybridized with a target nucleic acid.

Riken | Date: 2017-01-11

An object of the present invention is to provide a plant transformation method that is convenient and is widely applicable to various types of plant cells and nucleic acids. The present invention relates to a method for transforming a target plant, comprising the steps of:a) contacting a carrier peptide comprising a cell-penetrating sequence and a polycation sequence with a nucleic acid to form a complex; b) contacting the obtained complex with a cell of a meristem of the target plant to transfer the nucleic acid to the genome; c) allowing the meristem to grow; and d) selecting a plant harboring the transferred nucleic acid.

Riken | Date: 2017-03-15

A sliding member 1 according to one aspect of the present invention includes a base material 2 and a thermal spray coating 10 formed on a sliding surface of the base material 2, wherein the thermal spray coating 10 includes a molybdenum phase 11, a chromium carbide phase 12 and a nickel chromium alloy phase 13; the molybdenum phase 11, the chromium carbide phase 12 and the nickel chromium alloy phase are deposited on the sliding surface of the base material 2; and T_(CrC)/T_(Mo) is 0.46 to 1.00 where the average value of the thickness t_(CrC) of the chromium carbide phases 12 in the direction Y perpendicular to the surface of the base material 2 is T_(CrC), and the average value of the thickness t_(Mo) of the molybdenum phases 11 in the same direction thereof is T_(Mo).

Prostate cancer is one of the most common malignancies in males throughout the world, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10(-7) and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (lambda-corrected probability P(GC) = 3.9 x 10(-18)), GPRC6A/RFX6 (P(GC) = 1.6 x 10(-12)), 13q22 (P(GC) = 2.8 x 10(-9)), C2orf43 (P(GC) = 7.5 x 10(-8)) and FOXP4 (P(GC) = 7.6 x 10(-8)). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.

Hirano T.,RIKEN
Genes and Development | Year: 2012

Condensins are multisubunit protein complexes that play a fundamental role in the structural and functional organization of chromosomes in the three domains of life. Most eukaryotic species have two different types of condensin complexes, known as condensins I and II, that fulfill nonoverlapping functions and are subjected to differential regulation during mitosis and meiosis. Recent studies revealed that the two complexes contribute to a wide variety of interphase chromosome functions, such as gene regulation, recombination, and repair. Also emerging are their cell type- and tissue-specific functions and relevance to human disease. Biochemical and structural analyses of eukaryotic and bacterial condensins steadily uncover the mechanisms of action of this class of highly sophisticated molecular machines. Future studies on condensins will not only enhance our understanding of chromosome architecture and dynamics, but also help address a previously underappreciated yet profound set of questions in chromosome biology. © 2012 by Cold Spring Harbor Laboratory Press.

Takeichi M.,RIKEN
Nature Reviews Molecular Cell Biology | Year: 2014

Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape changes, particularly during embryonic development and in equivalent processes in adults. Accumulating evidence suggests that the remodelling of cell junctions, especially adherens junctions (AJs), has major roles in controlling these behaviours. AJs comprise cadherin adhesion receptors and cytoplasmic proteins that associate with them, including catenins and actin filaments, and exhibit various forms, such as linear or punctate. Remodelling of AJs induces epithelial reshaping in various ways, including by planar-polarized apical constriction that is driven by the contraction of AJ-associated actomyosin and that occurs during neural plate bending and germband extension. RHO GTPases and their effectors regulate actin polymerization and actomyosin contraction at AJs during the epithelial reshaping processes. copyright © 2014 Macmillan Publishers Limited.

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