Saitama, Japan
Saitama, Japan

RIKEN is a large research institute in Japan. Founded in 1917, it now has approximately 3000 scientists on seven campuses across Japan, the main one in Wako, just outside Tokyo. RIKEN is an Independent Administrative Institution whose formal name in Japanese is Rikagaku Kenkyūsho .RIKEN conducts research in many areas of science, including physics, chemistry, biology, medical science, engineering and computational science, and ranging from basic research to practical applications. It is almost entirely funded by the Japanese government, and its annual budget is approximately ¥88 billion . Wikipedia.


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To provide an oil scraper ring for a piston rod having excellent oil-scraping performance to reduce the amount of drain, and a stuffing box comprising such oil scraper rings, a ring body of the oil scraper ring is circumferentially divided to at least two, the ring body comprising a rail at an inner-side longitudinal center, a coil spring groove at an outer-side longitudinal center, and pluralities of oil drain grooves at least one of upper and lower surfaces, which are inclined such that their cross section areas increase as going from the inner side to the outer side.


The present invention relates to an actinic-ray-curable resin composition which comprises: (A) 100 parts by mass of a polyfunctional (meth)acrylate; (B) 0.2-4 parts by mass of a compound having an alkoxysilyl group and a (meth)acryloyl group; (C) 0.05-3 parts by mass of an organic titanium; and (D) 5-100 parts by mass of fine particles having an average particle diameter of 1-300 nm. The present invention also relates to a layered transparent resin product which comprises a hardcoat layer and a layer of a transparent resin sheet in this order from the outermost layer side, wherein the hardcoat has been formed from a coating material comprising:(A) 100 parts by mass of a polyfunctional (meth)acrylate; (B) 0.2-4 parts by mass of a compound having an alkoxysilyl group and a (meth)acryloyl group; (C) 0.05-3 parts by mass of an organic titanium; and (D) 5-100 parts by mass of fine particles having an average particle diameter of 1-300 nm.


To provide a press-fit, sintered valve seat having high valve coolability and wear resistance for use in a high-efficiency engine, and its production method, Cu powder having an average particle size of 45 m or less and purity of 99.5% or more is used to form a network-connected Cu matrix, even though a relatively large amount of hard Co-based alloy particles are added; and Fe-P alloy powder is used for densification by liquid-phase sintering.


Provided is a skyrmion memory circuit capable of circularly transferring a magnetic element skyrmion, comprising one or more current paths in a magnet having a closed-path pattern that are provided surrounding an end region including an end portion of the magnet in a plane of the magnet with the closed-path pattern, and applying current between an outer terminal connected to an outer circumferential portion of the closed-path pattern and an inner circumference electrode connected to an inner circumferential portion of the closed-path pattern, transferring the skyrmion in a direction substantially perpendicular to the direction of the applied current, and circulating the skyrmion in the magnet with the closed-path pattern.


Patent
Riken | Date: 2017-05-03

To provide a piston ring exhibiting excellent scuffing resistance and wear resistance, and a piston ring capable of avoiding edge loading, even in a severe use environment under increased pressure and thermal load, the outer peripheral sliding surface has a first curved surface, which is outward bulging in a cross section along a center axis of the piston ring; the first curved surface having a radius of curvature continuously increasing or decreasing as going from the crank case side to the combustion chamber side.


Patent
Riken | Date: 2017-05-17

A compression ring that makes it possible to suppress adhesion of a piston material to the compression ring is provided. The compression ring 11 includes an annular main body 12 that is constituted of a steel material consisting of 0.45 to 0.55 mass% of C, 0.15 to 0.35 mass% of Si, 0.65 to 0.95 mass% of Mn, 0.80 to 1.10 mass% of Cr, 0.25 mass% or less of V, less than 0.010 mass% of P, and a balance containing Fe and an inevitable impurity.


Patent
Riken, University of Tokyo and School Corporation | Date: 2017-02-15

Strains of human-derived bacteria have been obtained from complex fecal samples and shown to induce accumulation of Th17 cells in the intestine and promote immune functions. Pharmaceutical compositions containing these bacteria can be used as anti-infectives and as adjuvants in mucosal vaccines.


Patent
Riken and Sumitomo Chemical | Date: 2017-05-31

The present invention provides a method for inducing adenohypophysis or precursor tissue thereof in vitro from human pluripotent stem cells. The method includes culturing an aggregate of human pluripotent stem cells in suspension in a medium containing a bone morphogenetic protein signal transduction pathway activating substance and a substance acting on the Shh signal pathway to obtain a human cell aggregate containing a hypothalamus neuroepithelial tissue and a surface ectoderm, and further culturing the obtained human cell aggregate containing the hypothalamus neuroepithelial tissue and the surface ectoderm in suspension in a medium containing a bone morphogenetic protein signal transduction pathway activating substance and a substance acting on the Shh signal pathway to induce formation of hypophysial placode and/or Rathkes pouch in the surface ectoderm, thus obtaining a human cell aggregate containing 1) hypothalamus neuroepithelial tissue, and 2) hypophysial placode and/or Rathkes pouch.


Prostate cancer is one of the most common malignancies in males throughout the world, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10(-7) and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (lambda-corrected probability P(GC) = 3.9 x 10(-18)), GPRC6A/RFX6 (P(GC) = 1.6 x 10(-12)), 13q22 (P(GC) = 2.8 x 10(-9)), C2orf43 (P(GC) = 7.5 x 10(-8)) and FOXP4 (P(GC) = 7.6 x 10(-8)). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.


Takeichi M.,RIKEN
Nature Reviews Molecular Cell Biology | Year: 2014

Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape changes, particularly during embryonic development and in equivalent processes in adults. Accumulating evidence suggests that the remodelling of cell junctions, especially adherens junctions (AJs), has major roles in controlling these behaviours. AJs comprise cadherin adhesion receptors and cytoplasmic proteins that associate with them, including catenins and actin filaments, and exhibit various forms, such as linear or punctate. Remodelling of AJs induces epithelial reshaping in various ways, including by planar-polarized apical constriction that is driven by the contraction of AJ-associated actomyosin and that occurs during neural plate bending and germband extension. RHO GTPases and their effectors regulate actin polymerization and actomyosin contraction at AJs during the epithelial reshaping processes. copyright © 2014 Macmillan Publishers Limited.

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