Saitama, Japan
Saitama, Japan

RIKEN is a large research institute in Japan. Founded in 1917, it now has approximately 3000 scientists on seven campuses across Japan, the main one in Wako, just outside Tokyo. RIKEN is an Independent Administrative Institution whose formal name in Japanese is Rikagaku Kenkyūsho .RIKEN conducts research in many areas of science, including physics, chemistry, biology, medical science, engineering and computational science, and ranging from basic research to practical applications. It is almost entirely funded by the Japanese government, and its annual budget is approximately ¥88 billion . Wikipedia.

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Patent
Riken | Date: 2017-05-17

A compression ring that makes it possible to suppress adhesion of a piston material to the compression ring is provided. The compression ring 11 includes an annular main body 12 that is constituted of a steel material consisting of 0.45 to 0.55 mass% of C, 0.15 to 0.35 mass% of Si, 0.65 to 0.95 mass% of Mn, 0.80 to 1.10 mass% of Cr, 0.25 mass% or less of V, less than 0.010 mass% of P, and a balance containing Fe and an inevitable impurity.


Patent
Riken, University of Tokyo and School Corporation | Date: 2017-02-15

Strains of human-derived bacteria have been obtained from complex fecal samples and shown to induce accumulation of Th17 cells in the intestine and promote immune functions. Pharmaceutical compositions containing these bacteria can be used as anti-infectives and as adjuvants in mucosal vaccines.


The present invention relates to an actinic-ray-curable resin composition which comprises: (A) 100 parts by mass of a polyfunctional (meth)acrylate; (B) 0.2-4 parts by mass of a compound having an alkoxysilyl group and a (meth)acryloyl group; (C) 0.05-3 parts by mass of an organic titanium; and (D) 5-100 parts by mass of fine particles having an average particle diameter of 1-300 nm. The present invention also relates to a layered transparent resin product which comprises a hardcoat layer and a layer of a transparent resin sheet in this order from the outermost layer side, wherein the hardcoat has been formed from a coating material comprising:(A) 100 parts by mass of a polyfunctional (meth)acrylate; (B) 0.2-4 parts by mass of a compound having an alkoxysilyl group and a (meth)acryloyl group; (C) 0.05-3 parts by mass of an organic titanium; and (D) 5-100 parts by mass of fine particles having an average particle diameter of 1-300 nm.


To provide an oil scraper ring for a piston rod having excellent oil-scraping performance to reduce the amount of drain, and a stuffing box comprising such oil scraper rings, a ring body of the oil scraper ring is circumferentially divided to at least two, the ring body comprising a rail at an inner-side longitudinal center, a coil spring groove at an outer-side longitudinal center, and pluralities of oil drain grooves at least one of upper and lower surfaces, which are inclined such that their cross section areas increase as going from the inner side to the outer side.


Patent
Riken | Date: 2017-01-11

An object of the present invention is to provide a plant transformation method that is convenient and is widely applicable to various types of plant cells and nucleic acids. The present invention relates to a method for transforming a target plant, comprising the steps of:a) contacting a carrier peptide comprising a cell-penetrating sequence and a polycation sequence with a nucleic acid to form a complex; b) contacting the obtained complex with a cell of a meristem of the target plant to transfer the nucleic acid to the genome; c) allowing the meristem to grow; and d) selecting a plant harboring the transferred nucleic acid.


Patent
Riken and Kabushiki Kaisha Dnaform | Date: 2017-02-01

The present invention is intended to provide a novel fluorescent labeled single-stranded nucleic acid, by which the background of an exciton oligomer can be further reduced and the novel use thereof. The present invention relates to a labeled single-stranded nucleic acid having at least two fluorescent atomic group pairs that exhibit an exciton effect. The labeled single-stranded nucleic acid is characterized in that the emission peak wavelength of one of the fluorescent atomic group pairs (fluorescent atomic group pair A) is shorter than the excitation peak wavelength of the other fluorescent atomic group pair (fluorescent atomic group pair B), and the fluorescent atomic group pairs A and B have a Forster resonance energy transfer (FRET) effect. This fluorescent labeled single-stranded nucleic acid is usable as a primer for amplifying a target nucleic acid or a probe to be hybridized with a target nucleic acid.


Patent
Riken | Date: 2017-09-13

A polyester resin laminate having excellent adhesiveness to a printed layer is provided. The laminate comprises: (A) a resin film containing (a) a polyester-based copolymer having the properties (1) to (5) wherein (1) when the total of constituent units derived from a dicarboxylic acid component(s) is defined as 100 mol%, constituent units derived from terephthalic acid are contained at 98 to 100 mol%; (2) when the total of constituent units derived from diol components is defined as 100 mol%, constituent units derived from ethylene glycol are contained at 60.5 to 72.5 mol%; constituent units derived from diethylene glycol are contained at 1.5 to 6 mol%; and constituent units derived from 1,4-cyclohexanedimethanol are contained at 26 to 38 mol%; (3) the constituent units derived from 1,4-cyclohexanedimethanol are constituted by 65 to 75 mol% trans isomers and 35 to 25 mol% cis isomers, wherein the total of said trans isomers and said cis isomers is 100 mol%; (4) the ratio (Mw/Mn) between the mass average molecular weight (Mw) and the number average molecular weight (Mn) in terms of polystyrene as calculated from a differential molecular weight distribution curve measured by gel permeation chromatography is 2.9 to 3.8; and (5) the number average molecular weight (Mn) is 16,000 to 24,000; and (B) a printed layer composed of a colored ink containing a vinyl chloride-vinyl acetate copolymer, which printed layer is formed on at least one side of the resin film.


The present invention relates to developing and providing a technique for saccharifying a plant biomass, particularly a lignocellulosic biomass efficiently in fewer steps and at low cost while suppressing environmental load, in order to efficiently and effectively use the energy of the plant biomass. Provided are a cellulase activator containing a lignocellulose degradation cofactor consisting of an amino acid sequence represented by SEQ ID NO: 1 as an active ingredient and a method for saccharifying a lignocellulosic biomass using the cellulase activator.


Knopfel T.,RIKEN
Nature Reviews Neuroscience | Year: 2012

In a departure from previous top-down or bottom-up strategies used to understand neuronal circuits, many forward-looking research programs now place the circuit itself at their centre. This has led to an emphasis on the dissection and elucidation of neuronal circuit elements and mechanisms, and on studies that ask how these circuits generate behavioural outputs. This movement towards circuit-centric strategies is progressing rapidly as a result of technological advances that combine genetic manipulation with light-based methods. The core tools of these new approaches are genetically encoded optical indicators and actuators that enable non-destructive interrogation and manipulation of neuronal circuits in behaving animals with cellular-level precision. This Review examines genetically encoded reporters of neuronal function and assesses their value for circuit-oriented neuroscientific investigations. © 2012 Macmillan Publishers Limited. All rights reserved.


Takeichi M.,RIKEN
Nature Reviews Molecular Cell Biology | Year: 2014

Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape changes, particularly during embryonic development and in equivalent processes in adults. Accumulating evidence suggests that the remodelling of cell junctions, especially adherens junctions (AJs), has major roles in controlling these behaviours. AJs comprise cadherin adhesion receptors and cytoplasmic proteins that associate with them, including catenins and actin filaments, and exhibit various forms, such as linear or punctate. Remodelling of AJs induces epithelial reshaping in various ways, including by planar-polarized apical constriction that is driven by the contraction of AJ-associated actomyosin and that occurs during neural plate bending and germband extension. RHO GTPases and their effectors regulate actin polymerization and actomyosin contraction at AJs during the epithelial reshaping processes. copyright © 2014 Macmillan Publishers Limited.

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