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Jaipur, India

Gupta S.P.,RIICO Institutional Area | Garg G.,Sms Medical College And Attached Hospital
Journal of Children's Orthopaedics

Background: Management of gap nonunion of tibia is technically difficult, time consuming, physically and psychologically demanding for the patient with unpredictable results. Various techniques have been described in literature for the treatment of gap nonunions, but each one has its own limitations.Purpose: This study reports the outcomes of ipsilateral fibular transposition for reconstruction of tibial defects in paediatric age group.Methods: We retrospectively reviewed records of 14 patients who underwent surgery for gap nonunion tibia with ipsilateral tibialization of fibula. Fibula is transferred to tibia as pedicle graft in two-staged procedure. Due to retained blood supply to one end of the transplant, the graft easily takes up and hypertrophies upon weight bearing over a period of time.Results: Average time of radiographic union was 13.35 weeks. Guarded partial weight bearing was started at an average of 16.5 weeks with gradual progression to full weight bearing. The leg length discrepancy at final follow-up ranged from 0 to 7 cms with an average of 2.60 cms. Hypertrophy of tibialized fibula was observed in all patients, with 8 patients showed grafted fibula reaching the diameter of opposite tibia. On subjective assessment, 9 patients were highly satisfied, 4 patients were satisfied and one patient was dissatisfied with the procedure.Conclusions: Huntington procedure is a simple, cost-effective and easy procedure for large tibial defects in paediatric patients which does not require any specialized team and implants, and can be performed in moderately equipped hospital. Leg length discrepancy may be addressed, after the transferred fibula is well developed. © 2014, The Author(s). Source

Eswar P.,RIICO Institutional Area | Nagesh L.,Bapuji Dental College and Hospital | Devaraj C.,Mahatma Gandhi Dental College and Hospital

The aim of this preliminary study was to compare the intelligence quotient (IQ) scores of 12-14 year old school children living in a high fluoride (F) village with the IQ scores of a similar group of children in a low F village in the Davangere district, Karnataka, India. Sixty-five children from the one high school in the low F water village of Ajjihalli (F = 0.29 ppm) and 68 children from the one high school in the high F village of Holesirigere (F = 2.45 ppm) were selected by convenience sampling. Water F levels were estimated by the F ion selective electrode method. IQ scores were measured using Raven's Standard Progressive Matrices test. Chi-square and Z tests were used for statistical analysis of data. In the high F village of Holesirigere the mean IQ score of the 68 children was lower (86.3±12.8) than in the low F village of Ajjihalli, where the mean IQ score of 65 children was higher (88.8±15.3), but the difference was not statistically significant (p = 0.30) The number of children with IQ scores < 90 was 43/68 (63.2%) in high F Holesirigere and 31/65 (47.7%) in low F Ajjihalli, a difference that is nearly but not quite statistically significant (p = 0.06). The trend was toward lower IQ with high F water, even though these preliminary findings indicated that the F level in the drinking water was not significantly associated with IQ scores of 12-14 year old children in the high and low F villages. © 2011 The International Society for Fluoride Research Inc. Source

Gautam R.K.,RIICO Institutional Area | Bhambu A.K.,RIICO Institutional Area | Rai S.,RIICO Institutional Area | Sahu D.,Geetanjali Institute of Pharmacy
Research Journal of Pharmacy and Technology

Information Technology (IT) can be used potentially in every sector of the economy. Information Technology has been a dynamic sector in many developed economies and India has stood out as a developing country where IT sector has grown indefinitely. Information Technology jobs in India are the first choice career for the bright brains who are innovative. Hence, IT jobs in India are also booming with increasing demand for information technology professionals. Use of Information & Technology in Pharmacy field is known as health informatics. Health informatics is a discipline at the intersection of information science, computer science, and health care. It deals with the resources, devices, and methods required optimizing the acquisition, storage, retrieval, and use of information in health and biomedicine. Health informatics tools include not only computers but also clinical guidelines, formal medical terminologies, and information and communication systems. It is applied to the areas of nursing, clinical care, dentistry, pharmacy, public health, occupational therapy, and (bio) medical research. The review mainly focus on Health informatics, Medical writing, Medical transcription, Medical coding, Knowledge process outsourcing (KPO). © RJPT. Source

Saraswat P.,RIICO Institutional Area | Swarankar M.L.,RIICO Institutional Area | Swarankar M.L.,Jaipur Fertility and Microsurgery Research Center | Bhandari A.,Jodhpur National University | Soni R.R.,Jaipur Fertility and Microsurgery Research Center
International Journal of Pharma and Bio Sciences

A molecular method for early detection of active female genital tuberculosis from clinical endometrial tissue specimens was developed by modifying single tube nested reverse transcriptase polymerase chain reaction. The reliability of this method was compared with the gold standard culture method (a combination of Mycobacterium Growth Indicator Tube system and Lowenstein Jiensen media) that is a still corner stone on which a definitive diagnosis relies. The viability of Mycobacterium tuberculosis (half-life only 2-3 min), excellent yield and purity of isolated total ribonucleic acid from clinical tissue specimens were obtained by using commercially available kits and reagents. The use of special negative control (template without reverse transcriptase enzyme) makes the modified method more reliable for diagnostic purposes, since it checks deoxyribo nucleic acid contamination. Finally, early detection of active female genital tuberculosis is possible by this modified method rather than time consuming culture methods. Source

Tiwari P.C.,RIICO Institutional Area | Noor A.,RIICO Institutional Area | Chand K.,RIICO Institutional Area | Nagar K.,RIICO Institutional Area
International Journal of Pharmacy and Technology

Background: Soframycin and Honey supposedly increase the wound healing process and reduces the overall time taken by the wound to heal. Soframycin is an Anti-Bacterial drug used for treatments of Wounds, while Honey shows its wound healing activity by promoting Phase 3 and Phase 4 of wound healing. Phase 3 of Wound Healing is characterized by the presence of pebbled red tissue in the wound base and involves replacement of dermal tissues and sometimes sub dermal tissues in deeper wounds as well as contraction of the wound. In the remodelling phase (Phase 4) the wound matures. Collagen is remodelled and realigned along tension lines where the wound is contracting. During this process the cells that are no longer needed are removed by apoptosis. Thus by promoting Phase 3 & Phase 4 of Wound Healing Honey reduces the time taken by a wound to heal. Aim: To Compare the effectiveness of Soframycin and Honey in Wound Healing of Excised Animals. Excision Wound Model Method: Two groups of animals with three animals in each group were used for study. A round seal of 2.5 cm diameter was impressed on the hair removed dorsal thoracic area (5 cm away from the ears) of the ether anaesthetized rats. Full thickness skin from the demarked area was incised to produce a wound measuring around 500 mm2. The wound will be washed with cotton soaked in warm saline. Then the drugs Soframycin Gel & Honey were applied topically on the wounds once daily, starting from the day of wounding, till the wound is completely healed. Wound contraction (4th, 8th and12th day of wound healing) and period of epithelialization were the parameters studied. Results: After 12 days of observation, it was found that wound of animals treated with Soframycin healed completely, leaving a minimum scar, where as the wound of animals being treated with Honey, heals very little, leaving a huge scar on the animal skin. Conclusion: After completion of our study, we found that Soframycin has a higher wound healing capacity in comparison to the Honey. Source

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