RIICO Institutional Area

Jaipur, India

RIICO Institutional Area

Jaipur, India
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Gupta M.M.,RIICO Institutional Area | Srivastava B.,Jaipur National University
International Journal of Current Pharmaceutical Review and Research | Year: 2010

Aceclofenac spherical crystals were prepared by using a three solvent system comprising ethanol, dichloromethane (DCM), and water (good solvent, bridging liquid and bad solvent, respectively). Polyvinyl Pyrollidone (PVP-K-30) in different concentrations was used as hydrophilic polymer. The effect of speed of rotation, agitation time, temperature, mode of addition of bridging liquid, amount of bridging liquid as well as effect of different amounts of non-solvent (water) on spherical crystals were studied. The crystals were subjected to various evaluations such as %yield, drug content, particle size and particle size distribution, % fines, crushing strength, friability, packability and compression behaviour of spherical crystals(agglomerate) The agglomerates showed improved micromeritic properties as well as dissolution behaviour in comparison to conventional drug crystals. The optimized agglomerates showed good sphericity as well as high drug release, and hence they were compressed into tablets by direct compression.

Gupta M.M.,RIICO Institutional Area | Patel Mitul G.,RIICO Institutional Area | Patel Nimesh S.,RIICO Institutional Area | Kedawat M.,Banasthali University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

Ibuprofen is (NSAID) non-steroidal anti-inflammatory drug and used as analgesic & anti-inflammatory drug. It can be also used in the treatment of rheumatoid arthritis, osteoarthritis, and primary dysmenorrhea. Ibuprofen is absorbed rapidly, bound avidly to protein, but it has low aqueous solubility so, it also lowers the dissolution profile of drug. To overcome this problem, various techniques are used, like solid dispersion, complexation, co-solvency, hydrotrophy, nano technology approach. In this study, the dissolution rate of poorly soluble drug Ibuprofen was increased by preparing solid dispersion with urea in ratio of (1:1), (1:3) & (1:5) by using melt dispersion method & solvent evaporation method. The rate of dissolution of Ibuprofen was increased with the proportion of (1:5) when compared to the other formulations.

Singh D.,RIICO Institutional Area | Nainwani R.,RIICO Institutional Area | Gupta A.,RIICO Institutional Area
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: The purpose of this study was to evaluate the in vivo anti-inflammatory and anti-arthritic activity of hydroalcoholic extract of Pongamia pinnata (L.) Pierre seeds. Methods: The P. pinnata hydroalcoholic extract (PPHE) was tested against Carrageenan-induced paw edema inflammation and Freund's s Complete Adjuvant (FCA) induced arthritic rats. The standard drugs and PPHE (250 and 500 mg/kg) doses were administered orally in all experiments. Arthritis assessment and body weight were measured daily till day 28th whereas Determination of haematological parameters was measured on last day 28th. Results: Subplantar administration of Carrageenan and FCA results increased in paw volume, joint diameter whereas it reduced motor incoordination and nociceptive threshold. Treatment with PPHE showed significant (P < 0.001) inhibition of edema in Carrageenan induced paw edema. PPHE significantly (P < 0.001) decreased the arthritis which was evident with arthritis index, paw volume and joint diameter. It also significantly (P < 0.001) increased the mechanical hyperalgesias and nociceptive threshold. The hematological parameters also revealed the control in arthritis with PPHE. Conclusion: The present study was suggestive to that PPHE has prominent anti-inflammatory and anti-arthritic activity which may be mediated through the phytochemical constituents of the plant.

Nainwani R.,RIICO Institutional Area | Singh D.,RIICO Institutional Area | Gupta A.,RIICO Institutional Area | Patel H.,RIICO Institutional Area | Gautam R.K.,RIICO Institutional Area
International Journal of Pharmaceutical Sciences Review and Research | Year: 2014

Rheumatoid arthritis (RA) is a chronic, relapsing autoimmune disorder. Punica granatum (Punicaceae family) is a plant, which is reported to have anti-inflammatory activity. In view of its potent anti-inflammatory activity, present investigation was designed to evaluate anti-arthritic potential of various fraction of methanolic extract. The present investigation was carried out to determine the possible chemical components from methanolic fraction of Punica granatum rind extract. The evaluation of anti-arthritic activity was done by Protien denaturation method. n-heaxe, aqueous and butanolic fraction of methanolic extract showed potent anti-arthritic activity, but chloroform fraction did not showed anti-arthritic activity. Inhibition of protein denaturation was studied to establish the mechanism of Anti-arthritic effect of Punica granatum. Form the present findings it can be concluded that Punica granatum possessed marked anti-erthritic effect against denaturation of protein in vitro. The effect was plausibly due to flavonoid, alkaloid and terpenoids contents of Punica granatum.

Gautam R.K.,RIICO Institutional Area | Singh D.,RIICO Institutional Area | Nainwani R.,RIICO Institutional Area
International Journal of Pharmaceutical Sciences Review and Research | Year: 2013

Arthritis, literally meaning "inflammation of the joint," encompasses over 100 rheumatic diagnoses, with osteoarthritis and rheumatoid arthritis being the most prevalent. Rheumatoid arthritis is a systemic autoimmune disease with chronic inflammation characterized by hyperplasia of synovial cells and angiogenesis in affected joints, which ultimately leads to the destruction of cartilage and bone. Plants have been used since prehistoric times for treatment of various ailments. The uses of traditional medicines are widely spread and plants represent a large source of natural chemicals that might serve as leads for the development of the novel drugs. In this review, an attempt has been made to highlight the work on medicinal plants having anti-arthritic potential. This review may be helpful for the researchers for further research on the potential use of medicinal plants having antiarthritic property.

Dixit P.K.,RIICO Institutional Area | Mittal S.,RIICO Institutional Area
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Diabetes mellitus is one of the oldest diseases known to mankind and yet with the tremendous scientific advances witnessed in this century, medical science cannot claim that it knows all that needs to be known about this disease, including its management. This is the main reason for the persistent interest all over the world to explore alternative remedies from the so-called "alternative systems" of medicine. It is the fact that diabetes can it be cured and it has never been reported that someone had recovered totally from diabetes. The rapidly increasing incidence of diabetes mellitus is becoming a serious threat to mankind health in all parts of the world. Plants have been the major source of drugs in medicine and other ancient systems in the world. Herbals are a traditional medicine or folk medicine practice based on the use of plants and plant extracts. This review presents the profiles of plants with hypoglycaemic properties, reported in the literature. The profiles presented include information about the scientific name, family, methodology used.

Amit J.K.,RIICO Institutional Area | Rammulrajsinh R.,RIICO Institutional Area | Sonali D.,RIICO Institutional Area | Kinal P.,RIICO Institutional Area | Pradeep A.,RIICO Institutional Area
International Journal of PharmTech Research | Year: 2011

The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.

Tiwari P.C.,RIICO Institutional Area | Noor A.,RIICO Institutional Area | Chand K.,RIICO Institutional Area | Nagar K.,RIICO Institutional Area
International Journal of Pharmacy and Technology | Year: 2013

Background: Soframycin and Honey supposedly increase the wound healing process and reduces the overall time taken by the wound to heal. Soframycin is an Anti-Bacterial drug used for treatments of Wounds, while Honey shows its wound healing activity by promoting Phase 3 and Phase 4 of wound healing. Phase 3 of Wound Healing is characterized by the presence of pebbled red tissue in the wound base and involves replacement of dermal tissues and sometimes sub dermal tissues in deeper wounds as well as contraction of the wound. In the remodelling phase (Phase 4) the wound matures. Collagen is remodelled and realigned along tension lines where the wound is contracting. During this process the cells that are no longer needed are removed by apoptosis. Thus by promoting Phase 3 & Phase 4 of Wound Healing Honey reduces the time taken by a wound to heal. Aim: To Compare the effectiveness of Soframycin and Honey in Wound Healing of Excised Animals. Excision Wound Model Method: Two groups of animals with three animals in each group were used for study. A round seal of 2.5 cm diameter was impressed on the hair removed dorsal thoracic area (5 cm away from the ears) of the ether anaesthetized rats. Full thickness skin from the demarked area was incised to produce a wound measuring around 500 mm2. The wound will be washed with cotton soaked in warm saline. Then the drugs Soframycin Gel & Honey were applied topically on the wounds once daily, starting from the day of wounding, till the wound is completely healed. Wound contraction (4th, 8th and12th day of wound healing) and period of epithelialization were the parameters studied. Results: After 12 days of observation, it was found that wound of animals treated with Soframycin healed completely, leaving a minimum scar, where as the wound of animals being treated with Honey, heals very little, leaving a huge scar on the animal skin. Conclusion: After completion of our study, we found that Soframycin has a higher wound healing capacity in comparison to the Honey.

Gautam R.K.,RIICO Institutional Area | Bhambu A.K.,RIICO Institutional Area | Rai S.,RIICO Institutional Area | Sahu D.,Geetanjali Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2013

Information Technology (IT) can be used potentially in every sector of the economy. Information Technology has been a dynamic sector in many developed economies and India has stood out as a developing country where IT sector has grown indefinitely. Information Technology jobs in India are the first choice career for the bright brains who are innovative. Hence, IT jobs in India are also booming with increasing demand for information technology professionals. Use of Information & Technology in Pharmacy field is known as health informatics. Health informatics is a discipline at the intersection of information science, computer science, and health care. It deals with the resources, devices, and methods required optimizing the acquisition, storage, retrieval, and use of information in health and biomedicine. Health informatics tools include not only computers but also clinical guidelines, formal medical terminologies, and information and communication systems. It is applied to the areas of nursing, clinical care, dentistry, pharmacy, public health, occupational therapy, and (bio) medical research. The review mainly focus on Health informatics, Medical writing, Medical transcription, Medical coding, Knowledge process outsourcing (KPO). © RJPT.

Preeti,RIICO Institutional Area | Soni G.,RIICO Institutional Area
Proceedings - 2016 2nd International Conference on Computational Intelligence and Communication Technology, CICT 2016 | Year: 2016

In this work, a novel power efficient pulse triggered flip flop design with minimum no. of transistors is proposed. Proposed Flip-Flop (FF) has two new feature points. First point, the pulse generation control logic is designed with single modified inverter and a pass transistor which reduces the complexity and extra switching in pulse generator circuit. Second point, signal feed through technique with some modification is devised to speed up the charging and discharging along the critical path only when needed. As a result, no. of transistors in pulse generation circuit has been reduced for power and area saving. Various post layout simulation results based on CMOS 90-nm technology reveal that the proposed FF design has the highest power-delay product performance in all FF designs under comparison. © 2016 IEEE.

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