Houston, TX, United States
Houston, TX, United States

William Marsh Rice University, commonly referred to as Rice University or Rice, is a private research university located on a 295-acre campus in Houston, Texas, United States. The university is situated near the Houston Museum District and is adjacent to the Texas Medical Center. It is consistently ranked among the top 20 universities in the U.S. and the top 100 in the world.Opened in 1912 after the murder of its namesake William Marsh Rice, Rice is now a research university with an undergraduate focus. Its emphasis on education is demonstrated by a small student body and 5:1 student-faculty ratio, among the lowest in the top American universities including the Ivy League. The university has produced 101 Fulbright Scholars, 11 Truman Scholars, 24 Marshall Scholars, 12 Rhodes Scholars, 3 Nobel Laureates, 2 Pulitzer Prize winners, and at least 2 deceased and 2 living billionaires. The university has a very high level of research activity for its size, with $115.3 million in sponsored research funding in 2011. Rice is noted for its applied science programs in the fields of artificial heart research, structural chemical analysis, signal processing, space science, and nanotechnology. It was ranked first in the world in materials science research by the Times Higher Education in 2010. Rice is a member of the Association of American Universities.Rice is noted for its entrepreneurial activity, and has been recognized as the top ranked business incubator in the world by the Stockholm-based UBI Index for both 2013 and 2014.The university is organized into eleven residential colleges and eight schools of academic study, including the Wiess School of Natural science, the George R. Brown School of Engineering, the School of Social science, and the School of Humanities. Graduate programs are offered through the Jesse H. Jones Graduate School of Business, School of Architecture, Shepherd School of Music, and Susanne M. Glasscock School of Continuing Studies. Rice students are bound by the strict Honor Code, which is enforced by a uniquely student-run Honor Council.Rice competes in 14 NCAA Division I varsity sports and is a part of Conference USA, often competing with its cross-town rival the University of Houston. Intramural and club sports are offered in a wide variety of activities such as jiu jitsu, water polo, and crew. Wikipedia.


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The present invention provides an oligonucleotide composition including a blocker and a first primer oligonucleotide. The blocker oligonucleotide includes a first sequence having a target-neutral subsequence and a blocker variable subsequence. The non-target specific subsequence is flanked on its 3 and 5 ends by the target-neutral subsequence and is continuous with the target-neutral subsequence. The first primer oligonucleotide is sufficient to induce enzymatic extension; herein the first primer oligonucleotide includes a second sequence. The second sequence overlaps with the 5 end of the target-neutral subsequence by at least 5 nucleotides; herein the second sequence includes an overlapping subsequence and a non-overlapping subsequence. The second sequence does not include the non-target specific subsequence.


Patent
Rice University | Date: 2016-09-23

Embodiments of the present invention provide methods of preparing functionalized graphene nanoribbons by (1) exposing a plurality of carbon nanotubes to an alkali metal source in the presence of an aprotic solvent, wherein the exposing opens the carbon nanotubes; and (2) exposing the opened carbon nanotubes to an electrophile to form functionalized graphene nanoribbons. Such methods may also include a step of exposing the opened carbon nanotubes to a protic solvent in order to quench any reactive species on the opened carbon nanotubes. Further embodiments of the present invention pertain to graphene nanoribbons formed by the methods of the present invention. Additional embodiments of the present invention pertain to nanocomposites and fibers containing the aforementioned graphene nanoribbons.


The present disclosure describes the thermodynamic design and concentrations necessary to design probe compositions with desired optimal specificity that enable enrichment, detection, quantitation, purification, imaging, and amplification of rare-allele-bearing species of nucleic acids (prevalence <1%) in a large stoichiometric excess of a dominant-allele-bearing species (wildtype). Being an enzyme-free and homogeneous nucleic acid enrichment composition, this technology is broadly compatible with nearly all nucleic acid-based biotechnology, including plate reader and fluorimeter readout of nucleic acids, microarrays, PCR and other enzymatic amplification reactions, fluorescence barcoding, nanoparticle-based purification and quantitation, and in situ hybridization imaging technologies.


Patent
Rice University | Date: 2016-08-15

The invention relates to recombinant microorganisms that have been engineered to produce various chemicals using genes that have been repurposed to create a reverse beta oxidation pathway. Generally speaking, the beta oxidation cycle is expressed and driven in reverse by modifying various regulation points for as many cycles as needed, and then the CoA thioester intermediates are converted to useful products by the action of termination enzymes.


Patent
Rice University | Date: 2017-02-15

The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions.


Various embodiments of the present disclosure pertain to methods of forming polymer composites that include polymers and graphene quantum dots. The methods occur by mixing a polymer component (e.g., polymers, polymer precursors and combinations thereof) with graphene quantum dots. In some embodiments, the polymers are in the form of a polymer matrix, and the graphene quantum dots are homogenously dispersed within the polymer matrix. In some embodiments, the graphene quantum dots include, without limitation, coal-derived graphene quantum dots, coke-derived graphene quantum dots, unfunctionalized graphene quantum dots, functionalized graphene quantum dots, pristine graphene quantum dots, and combinations thereof. Additional embodiments of the present disclosure pertain to polymer composites that are formed by the methods of the present disclosure. In some embodiments, the polymer composites of the present disclosure are fluorescent and optically transparent. In some embodiments, the polymer composites of the present disclosure are in the form of a film.


Embodiments of the present disclosure pertain to methods of making conductive films by associating an inorganic composition with an insulating substrate, and forming a porous inorganic layer from the inorganic composition on the insulating substrate. The inorganic layer may include a nanoporous metal layer, such as nickel fluoride. The methods of the present disclosure may also include a step of incorporating the conductive films into an electronic device. The methods of the present disclosure may also include a step of associating the conductive films with a solid electrolyte prior to its incorporation into an electronic device. The methods of the present disclosure may also include a step of separating the inorganic layer from the conductive film to form a freestanding inorganic layer. Further embodiments of the present disclosure pertain to the conductive films and freestanding inorganic layers.


Halas N.J.,Rice University
Nano Letters | Year: 2010

While studies of surface plasmons on metals have been pursued for decades, the more recent appearance of nanoscience has created a revolution in this field with "Plasmonics" emerging as a major area of research. The direct optical excitation of surface plasmons on metallic nanostructures provides numerous ways to control and manipulate light at nanoscale dimensions. This has stimulated the development of novel optical materials, deeper theoretical insight, innovative new devices, and applications with potential for significant technological and societal impact. Nano Letters has been instrumental in the emergence of plasmonics, providing its readership with rapid advances in this dynamic field. © 2010 American Chemical Society.


Dai P.,Rice University
Reviews of Modern Physics | Year: 2015

High-transition temperature (high-Tc) superconductivity in the iron pnictides or chalcogenides emerges from the suppression of the static antiferromagnetic order in their parent compounds, similar to copper oxide superconductors. This raises a fundamental question concerning the role of magnetism in the superconductivity of these materials. Neutron scattering, a powerful probe to study the magnetic order and spin dynamics, plays an essential role in determining the relationship between magnetism and superconductivity in high-Tc superconductors. The rapid development of modern neutron time-of-flight spectrometers allows a direct determination of the spin dynamical properties of iron-based superconductors throughout the entire Brillouin zone. In this paper, an overview is presented of the neutron scattering results on iron-based superconductors, focusing on the evolution of spin-excitation spectra as a function of electron and hole doping and isoelectronic substitution. Spin dynamical properties of iron-based superconductors are compared with those of copper oxide and heavy fermion superconductors and the common features of spin excitations in these three families of unconventional superconductors and their relationship with superconductivity are discussed. © 2015 American Physical Society.


Ball Z.T.,Rice University
Accounts of Chemical Research | Year: 2013

Chemists have long been fascinated by metalloenzymes and their chemistry. Because enzymes are essential for biological processes and to life itself, they present a key to understanding the world around us. At the same time, if chemists could harness the reactivity and selectivity of enzymes in designed transition-metal catalysts, we would have access to a powerful practical advance in chemistry. But the design of enzyme-like catalysts from scratch presents enormous challenges. Simplified, designed systems often don't provide the opportunity to mimic the complex features of enzymes such as selectivity in polyfunctional environments and access to reactive intermediates incompatible with bulk aqueous solution.Extensive efforts by numerous groups have led to remarkable designed metalloproteins that contain complex folds, including well-defined secondary and tertiary structure surrounding complex polymetallic centers. These structural achievements, however, have not yet led to general approaches to useful catalysts; continued efforts and new insights are needed. Our efforts have combined the attributes of enzymatic and traditional catalysis, bringing the benefits of polypeptide ligands to bear on completely nonbiological transition-metal centers. With a focus on designing useful catalytic activity, we have examined rhodium(II) carboxylates, bound to peptide chains through carboxylate side chains. Among other advantages, these complexes are stable and catalytically active in water.Our efforts have centered on two main interests: (1) understanding how Nature's ligand of choice, polypeptides, can be used to control the chemistry of nonbiological metal centers, and (2) mimicking metalloenzyme characteristics in designed, nonbiological catalysts. This Account conveys our motivation and goals for these studies, outlines progress to date, and discusses the future of enzyme-like catalyst design.In particular, these studies have resulted in on-bead, high-throughput screens for asymmetric metallopeptide catalysts. In addition, peptide-based molecular recognition strategies have facilitated the site-specific modification of protein substrates. Molecular recognition enables site-specific, proximity-driven modification of a broad range of amino acids, and the concepts outlined here are compatible with natural protein substrates and with complex, cell-like environments. We have also explored rhodium metallopeptides as hybrid organic-inorganic inhibitor molecules that block protein-protein interactions. © 2012 American Chemical Society.

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