Time filter

Source Type

Nath S.,Rgkar Medical College And Hospital | Bandyopadhyay S.K.,Director of Medical Education | Mandal T.K.,WBUAFS | Das A.K.,Rgkar Medical College And Hospital
Toxicology and Environmental Health Sciences | Year: 2016

Arsenic poisoning is one of the major causes of chronic human illness and mortality in Bengal Delta plain with limited treatment option. The present study was conducted to evaluate the ameliorating effect of Bauhinia acuminata L (Leguminosae: Caesalpinioideae) stem-bark powder against sodium arsenite (NaAsO2) induced toxicity. Forty eight adult albino rats were divided into four groups viz., D0, D1, D2 and D3. Sodium arsenite was administered @4 mg/kg daily in drinking water in groups D1, D2 and D3 for 90 days; control group (D0) received water for 120 days. The D1 group of animals received water, instead of arsenic during 91-120 days, while rats of group D2 and D3 were orally treated with stem bark powder @350 mg/kg (1/10 th dose of LD50) and 175 mg/kg (1/20 th dose of LD50) respectively daily during the period. Analysis of arsenic concentrations in tissue samples, hair and faeces showed that treatment with B. acuminata stem bark powder significantly (p<0.05) reduced arsenic accumulation in tissues, hair and in faeces. A significantly (p<0.05) higher organo-arsenic fraction and lower arsenite and arsenate fractions was also observed in B. acuminata stem bark powder treated group (D2 and D3). The study showed that oral treatment with B. acuminata stem bark powder could ameliorate induced arsenicosis. © 2016, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht.


Bandyopadhyay S.K.,Director of Medical Education | Mandal T.K.,WBUAFS | Das A.K.,Rgkar Medical College And Hospital | Mishra A.,WBUAFS
International Journal of Pharma and Bio Sciences | Year: 2016

Arsenic poisoning is one of the major causes of chronic human illness and mortality in Bengal Delta plain with limited treatment options. The present study was conducted to evaluate the ameliorating effect of Glycosmis pentaphylla (Rutaceae) leaf extract against sodium arsenite (NaAsO2) induced toxicity. Forty eight adult albino rats were divided into four groups viz., G0, G1, G2 and G3. Sodium arsenite was administered @ 4mg/kg daily in drinking water in groups G1, G2 and G3 for 90 days; the control group (G0) received water for 120 days. The G1 group of animals received water, instead of arsenic during 91-120 days, while rats of group G2 and G3 were orally treated with plant leaf extract at 320 mg/kg (1/10th LD50) and 160 mg/kg (1/20th LD50) respectively daily during the period. Analysis of arsenic concentrations in tissue samples, hair and faeces showed that treatment with G. pentaphylla leaf extract significantly (p < 0.05) reduced arsenic accumulation in tissues, hair and in faeces. A significantly (p < 0.05) higher organo-arsenic fraction and lower arsenite and arsenate fraction was also observed in G. pentaphylla leaf extract treated group(G2 & G3). The study showed that oral treatment with G. pentaphylla leaf extract could ameliorate induced arsenicosis.


Mukhopadhyay P.,NRS Medical College | Paul B.,Rgkar Medical College And Hospital | Das D.,NRS Medical College | Sengupta N.,NRS Medical College | Majumder R.,NRS Medical College
International Journal of Diabetes in Developing Countries | Year: 2010

Background: In the context of an alarming increase in the magnitude of type 2 diabetes mellitus in Indian population, the prevailing perceptions and practices of diabetics assume immense importance in the control of disease. Methods: This study was conducted with the aim of assessing the knowledge, attitude and self-reported practices regarding diabetes among the patients attending an OPD in a tertiary care hospital in Kolkata using a pretested questionnaire. Results: The findings of this study revealed that knowledge regarding symptoms and complications of the disease was poor except for frequent urination (42.2%) and eye complication (62.5%); however, only 25% patients had gone for eye examination during the last 1-year of their treatment. Awareness on detecting early complications of diabetes like periodic eye examination, BP monitoring and awareness on hypoglycemia, foot care were found to be poor. Attitude toward regular exercise and dietary modification in diabetics was found to be favorable in the majority; however, while compliance to dietary modification was reported to be high (82.8%) it was low with regular exercise (32.8%). Conclusion: Diabetic patients rely mostly on drugs and dietary modification for disease control while neglecting other lifestyle modification. Promotion of healthy lifestyle modifications and self-care should be incorporated as part of diabetes education in all treatment facilities.


Chatterjee S.,Rgkar Medical College And Hospital | Datta A.,University of Delhi | Chatterjee P.,University of Delhi
Indian Journal of Endocrinology and Metabolism | Year: 2015

Mountford Joseph Bramley was one of the educationists whose sincere efforts are undeniable in the making of modern India. After achieving the Member of the Royal College of Surgeons diploma, he joined the Malta Garrison as a Hospital Assistant and was soon promoted to the rank of Assistant Surgeon of the Rifle Brigade. Following his arrival in India in 1826, he held several important medical posts in the British service. He was one of the early researchers to investigate the role of iodine in the causation of goitre. He was appointed as the first Principal of the Medical College of Bengal, the oldest medical college in Asia, in 1835. Bramley was an educationist from the very core of his heart, and he always wished for the betterment of his students. He died early at the age of 34 years. His legacy as a pioneer in the fields of medical education and endocrinology, specifically thyroidology, has largely been shrouded in a miasma of time.


Mukherjee A.,Rg Kar Medical College And Hospital | Haldar D.,Rgkar Medical College And Hospital | Dutta S.,Rg Kar Medical College And Hospital | Dutta M.,Rg Kar Medical College And Hospital | And 2 more authors.
International Journal of Pediatric Otorhinolaryngology | Year: 2011

Objective: Ear nose and throat foreign bodies in children are one of the most common emergencies faced by otorhinolaryngologists. Our objective in the study conducted in the otolaryngology department of R.G. Kar Medical College & Hospital was to find out the socio-demographic correlates of self inflicted foreign body insertion in ear-nose-throat in children presenting in out patient department and emergency. Methods: A cross sectional descriptive study was conducted from October 2009 to March 2010 in the out patient department and emergency of otolaryngology. Using a predesigned and pretested questionnaire, socio-demographic data was collected prospectively on every alternate day by examining clinically all new pediatric patients attending with self-inflicted foreign body and interviewing their caregivers after removal of foreign body. The data collected from 288 children was analyzed by using simple proportion, odds ratio with 95% confidence interval, χ 2, t-test and analysis of one way variance (ANOVA) test. Epi info 3.4.3 version (CDC, Atlanta, retrieved from WHO website, on 01.11.09) and SPSS 17.0 were used for statistical calculations. Results: Analysis showed male preponderance (59.72%) of cases from urban area (63.9%), predominance of 0-5 years age group with 5.19 ± 3.02 (mean ± standard deviation) years average age, nasal foreign body was on the top (44.4%), majority from low income (58.33%) joint family (65.3%) with housewives (75.0%) as primary care giver, majority of whom reported to have nil or low literacy (61.1%). 19.4% subjects having local pathology showed significant association with urban residence, joint family, low socio-economic status and two or less than two children of the mother of the participant children. Past history of similar incidence was found in 22.2% of study subjects and significantly associated with nasal foreign body insertion and higher among the children of housewives. Conclusions: Increasing awareness of the prime caregivers by the routine grass root level health workers may be tried to reduce incidence of this risky health event and capacity building of the Primary level physicians to handle foreign body insertion cases can lessen the stress of the victim children and their parents. © 2011 Elsevier Ireland Ltd.


Chowdhury K.,Rgkar Medical College And Hospital | Saha S.,Rgkar Medical College And Hospital | Saha V.P.,Rgkar Medical College And Hospital | Pal S.,Rgkar Medical College And Hospital | Chatterjee I.,Ali Yavar Jung Natioanal Institute for the Hearing Handicapped
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2013

The present study was undertaken to assess the efficacy of medialization thyroplasty on outcome of voice quality in vocal cord paralysis by analyzing the voice. A total 19 patients with vocal cord paralysis of different etiologies were included in the study. Preoperative voice analysis was done by voice recordings, GRBAS score, maximum phonation time (MPT) and acoustic analysis using Dr Speech software (University version 4.0) using habitual fundamental frequency (F0), jitter %, shimmer % and normalized noise energy (NNE) as parameters. 18 patients underwent type 1 or medialization thyroplasty alone and 1 patient had undergone medialization thyroplasty along with arytenoids adduction. Post operative voice analysis was done using same parameters. There was post operative improvement of voice in 16 patients whereas 3 patients showed no significant improvement. Mean preoperative MPT was 4.8947 s and post operative was 13 s. Mean preoperative GRBAS score was 76.1579 and post operative was 30. On acoustic analysis, mean preoperative habitual fundamental frequency (F0), jitter %, shimmer % and NNE was 278.16 Hz, 1.7, 6.81 and 1.81 dB respectively whereas post operative mean was 132.37 Hz, 0.41, 1.65 and 123.38 dB respectively. Thyroplasty offers good voice outcome in patients of uncompensated vocal cord paralysis. Improvement can be documented in terms of perceptual evaluation of voice and acoustic analysis as well as maximum phonation time in addition to voice recording. © 2013 Association of Otolaryngologists of India.


Hazra S.,West Bengal University of Animal and Fishery Sciences | Palui H.,West Bengal University of Animal and Fishery Sciences | Biswas B.,Rgkar Medical College And Hospital | Konar A.,Indian Institute of Chemical Technology
Scandinavian Journal of Laboratory Animal Science | Year: 2011

The purpose of the study was to assess a ketamine/xylazine combination along with retrobulbar block using 4% lignocaine HCl for performing intraocular surgery in rabbits. To do so ten healthy adult New Zealand White rabbits aged 1.5-2 years of either sex weighing 2-3 kgs were selected for unilateral cataract extraction by phacoemulsification. Xylazine HCl was used as preanesthetic at a dose rate of 5 mg/kg, i.m., followed by Ketamine HCl at a dose rate of 35mg/kg, i.m. A retro bulbar block was performed with 4% lignocaine HCL. The anesthetic depth was judged by ear pinching reflex. The time for onset and duration of anesthesia was found to be 7±0.5 minutes and 35.5±1.2 minutes respectively. A central eyeball fixation following retro bulbar block was obtained in all the cases. The mean values recorded before induction of anesthesia and during anesthesia of rectal temperature (38.09°C±0.2 vs. 37.29°C±0.2), heart rate in beats per minute (276±1.2 vs.272±1.1), arterial blood pH (7.35±0.02 vs. 7.32±0.02), bicarbonate (16.2±1.2 vs. 20.3±1.8), PaCo2 (26.09±2.3 vs. 27.52±2.3) and PaO2 (84.79±1.9 vs. 80.39±1.1) did not vary significantly (P>0.05). Recovery was smooth and complete in 32.5±2.8 minutes. Conclusion: the anesthetic regimen provides adequate condition for conducting intraocular surgery in rabbits.


Maji R.,Rgkar Medical College And Hospital | Nath S.,Rgkar Medical College And Hospital | Lahiri S.,Rgkar Medical College And Hospital | Saha Das M.,Rgkar Medical College And Hospital | And 2 more authors.
Indian Journal of Clinical Biochemistry | Year: 2014

Reference intervals (RIs) of serum thyroid stimulating hormone (TSH) and free thyroxine (fT4) were determined in 402 healthy pregnant women by enzyme-linked immunosorbent assay (ELISA) technique after partitioning them into three trimesters. The reference population was chosen from a study population of 610 pregnant females by applying strict inclusion and exclusion criteria. The assays were done using proper quality control measures. RIs were calculated from the central 95 % of the distribution of TSH and fT4 values located between the lower reference limit of 2.5 percentile and upper reference limit of 97.5 percentile value 0.90 confidence intervals for the upper and lower reference limits were also determined. The reference intervals for TSH were 0.25-3.35 μIU/ml for the first trimester; 0.78-4.96 μIU/ml for the second trimester and 0.89-4.6 μIU/ml for the third trimester. Similarly, the reference intervals for fT4 for first, second and third trimesters were 0.64-2.0, 0.53-2.12 and 0.64-1.98 ng/dl respectively. The values thus obtained varied from those provided by the kit literature. In comparison to our derived reference intervals, the reference data from kit manufacturer under-diagnosed both subclinical hypo- and hyper-thyroidism within our pregnant reference population. © 2013 Association of Clinical Biochemists of India.


PubMed | P.A. College and Rgkar Medical College And Hospital
Type: Journal Article | Journal: Indian journal of clinical biochemistry : IJCB | Year: 2014

Reference intervals (RIs) of serum thyroid stimulating hormone (TSH) and free thyroxine (fT4) were determined in 402 healthy pregnant women by enzyme-linked immunosorbent assay (ELISA) technique after partitioning them into three trimesters. The reference population was chosen from a study population of 610 pregnant females by applying strict inclusion and exclusion criteria. The assays were done using proper quality control measures. RIs were calculated from the central 95% of the distribution of TSH and fT4 values located between the lower reference limit of 2.5 percentile and upper reference limit of 97.5 percentile value 0.90 confidence intervals for the upper and lower reference limits were also determined. The reference intervals for TSH were 0.25-3.35IU/ml for the first trimester; 0.78-4.96IU/ml for the second trimester and 0.89-4.6IU/ml for the third trimester. Similarly, the reference intervals for fT4 for first, second and third trimesters were 0.64-2.0, 0.53-2.12 and 0.64-1.98ng/dl respectively. The values thus obtained varied from those provided by the kit literature. In comparison to our derived reference intervals, the reference data from kit manufacturer under-diagnosed both subclinical hypo- and hyper-thyroidism within our pregnant reference population.


PubMed | Lane College, Rgkar Medical College And Hospital and Rgkar Medical College
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2014

Over the past several decades, the use of drug therapy in COPD has expanded, and provides an optimistic picture. Methyixanthines are used freely in COPD. Of them, Theophylline is an age old bronchodilator and anti-inflammatory agent while Acebrophylline is a newer one. Both are used as add on therapy in management of stable COPD patients on LAMA (long acting muscarinic antagonists like Tiotropium) in present day respiratory practice. This study was designed to compare the efficacy as well as tolerability/side-effects of these two drugs at recommended doses.An open randomized comparative longitudinal study was conducted on 40 moderate degree COPD patients over a period of one year. The patients were randomized into Group-1:receiving Acebrophylline 100mg twice daily and Group-2: receiving sustained release (SR) Theophylline 300mg once daily orally, in addition to 18gm Tiotropium inhalation per day through metered dose inhaler. Spirometric variables, symptomatic benefit and adverse effects were recorded on three visits (day 0, 21 and 42). All the data were analyzed by SPSS version 17.A comparable clinical improvement of symptoms score and spirometric parameters with both the drugs has been observed (p-value>0.05). Amount of sputum, frequency of use of reliever medication and dyspnoea showed improvement with both the drugs but cardiovascular side effects are less with Acebrophylline.This study reaffirms the rationale of use of Methylxanthines as add on therapy with LAMA in COPD management and cardiac safety level with Acebrophylline was considerable.

Loading Rgkar Medical College And Hospital collaborators
Loading Rgkar Medical College And Hospital collaborators