Kolkata, India
Kolkata, India

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Bhattacharya S.M.,Vivekananda Institute of Medical science | Ghosh M.,Rg Kar Medical College
Journal of Pediatric and Adolescent Gynecology | Year: 2010

Study Objectives: To estimate (1) the prevalence of insulin resistance (IR), by fasting glucose: insulin ratio (G:I < 7.0) in adolescent girls with polycystic ovary syndrome (PCOS), (2) to compare the clinical and biochemical parameters between insulin-resistant and non-insulin resistant groups. Design: Case series. Setting: Clinic based. Participants: 49 adolescent girls with complaints of oligomenorrhoea with hirsutism and or acne. Interventions: Forty-nine adolescent girls diagnosed to have PCOS (Rotterdam 2003 criteria) were studied. Body mass index (BMI), abdominal circumference (AC), hirsutism (Ferriman Gallway score ≥ 6), presence of acne, acanthosis nigricans (AN) were noted in each case. Serum testosterone, sex hormone binding globulin (SHBG), fasting plasma glucose and insulin levels were measured. Free androgen index (FAI) was calculated. Results: 69.4% of these girls were found to have IR. There were no differences in age, BMI, AC, serum testosterone, FAI and fasting glucose levels between insulin resistant and non-insulin resistant girls. But there were significant differences in frequencies of hirsutism, acne, AN, and serum levels of SHBG and fasting insulin between the two groups. Conclusion: Adolescent girls with PCOS and IR are more hirsute and have more AN and lower SHBG and higher fasting insulin levels compared to non-insulin resistant girls. © 2010 North American Society for Pediatric and Adolescent Gynecology.

Ghosh T.,RG Kar Medical College
Journal of the Indian Medical Association | Year: 2010

To find out the clinicoradiomycopathological profile of allergic bronchopulmonary Aspergillosis (ABPA) and incidences of aspergillus hypersensitivity (AH) among asthma patients, 215 consecutive extrinsic asthma patients were screened with aspergillus intradermal test and those found positive for AH were investigated further for ABPA. Out of 215 asthma patients (124 males and 91 females), 54 were hypersensitive to AH and 15 of them fulfilled criteria for ABPA. On repeated culture of sputum and/or broncho-alveolar lavage fluid, A flavuswas the most common isolate (40%), followed by A fumigatus (26.67%). No species was isolated in 4 cases (26.6%). AH/ABPA is not very uncommon in this part of the country. Diseases similar to ABPA caused by other fungus might be diagnosed if allergen tests for other fungal antigens are made widely available. A strong clinical suspicion and proper laboratory backup is essential for diagnosing ABPA and related diseases.

Chowdhury A.R.,Rg Kar Medical College | Dey R.K.,Rg Kar Medical College
Indian Journal of Urology | Year: 2013

Bacille Calmette-Guérin (BCG) is an effective treatment for patients with superficial bladder cancer and bladder carcinoma in situ (CIS). It may cause side effects usually due to local and systemic inflammatory effects. We report a case of a male patient with non-invasive urothelial carcinoma of urinary bladder (Stage T1) who developed caseating granulomas on his glans penis as a complication of intravesical BCG immunotherapy. Though there are other reported cases of BCG dissemination noted in the literature, penile granuloma is rare. The first reported case was published in 1992 and since then only eleven cases are reported. It appears that both direct infectious processes and hypersensitivity reactions contribute to the clinical manifestations of a systemic BCG infection. Our case possibly represents a local infection of M bovis involving the glans penis.

Ghosh S.K.,Rg Kar Medical College
Indian Journal of Dermatology | Year: 2013

Imatinib mesylate (IM), an anticancer drug, has been widely used to treat chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GIST), and dermato-fibrosarcoma protuberans. Cutaneous reactions to IM have been reported to occur in varying number of patients in different case series. Non-lichenoid cutaneous reactions secondary to IM have been well-documented in the literature and are the commonest non-hematologic adverse reactions associated with its use. Lichenoid drug eruption (LDE) associated with IM therapy has rarely been reported in the literature. A case of a generalized LDE associated with IM therapy has been described here for its rarity and interesting clinical presentation. As the clinical usage of IM is increasing, one might expect an increasing number of similar patients in the future. It is thus important to realize the potential of IM to produce LDE and to differentiate this entity from idiopathic lichen planus. In the present article, the reports of IM-associated LDE, described in the PubMed and Medline database (in English language literature), have also been reviewed.

Snake bite is a neglected public health problem in India. Very few community based epidemiological studies in India have been published so far on this issue. Most of the studies were carried out on hospital data. Previous community-based survey in the state revealed that only 22% snake bite victims attended hospitals. The objective of the present study is to find out the epidemiological profile of snake bite in eight blocks of the South 24-Paraganas district of West Bengal and to explore the under reporting of snake bite deaths in health facilities in that area during the study period. A retrospective analysis of snake bite data was carried out from a community-based epidemiological survey on 1.9 million populations. This survey was done door-to-door from January 2009 to October 2010 to get epidemiological profile of snake bite of the previous 2 years. The data of direct survey was compared with the official report of the same area to evaluate the hospital-based data with focus on underreporting of snakebite deaths. A total number of snake bite cases as found in the survey in the study area was 4871. There was a huge gap between the two data (direct survey and official data). Only 7.23% snake bite deaths were officially reported. Only 22.19% of the snake bite victims attended the hospitals. Nearly 65.7% of the snake bite deaths were due to common krait bite, most of them occurring in the months of June to September. Official reporting system is still having a huge deficiency in India. Snake bite needs to get more attention from the health authority.

Meyur R.,Rg Kar Medical College
Nepal Medical College journal : NMCJ | Year: 2011

Nowadays medical teachers use different audiovisual (AV) aids of teaching in their classes to make the subject more interesting and understandable. To assess the impact of three common lecture delivery methods, viz Blackboard (BB), Transparency and Over Head Projector (OHP) and Powerpoint Presentation (PP), a questionnaire based study was carried out among first year MBBS students of R.G.Kar Medical College, Kolkata. One hundred fouty students of academic session 2010-2011 were exposed to different aids of teaching, viz. Black Board (BB), Over Head Projector (OHP), power point presentation (PP) for ten months. They were taught Anatomy by different teachers who used all the three AV aids in their lectures. Then they were asked to respond to a questionnaire regarding these three AV aids of teaching. The students preferred Black Board teaching over OHP and result was statistically significant (p value < 0.0001). BB teaching was also preferred over PP presentations (p < 0.02). But in comparison to OHP, students preferred PP though the difference is not statistically significant (p < 0.10). Most of the students still prefer Black Board teaching to other modern AV aids like OHP and PP. For better understanding of a subject by students and improvement of their performance, a teacher should match the lectures with preferred AV aids and use the AV aids prudently.

Biswas J.,Rg Kar Medical College
Indian journal of public health | Year: 2012

Eye diseases in childhood are important causes of medical consultation and it affects learning ability, adjustment in school and personality. To determine the pattern of ocular morbidity a cross-sectional observational study was conducted among 714 children, attending Ophthalmology department at a tertiary eye care center in Kolkata, West Bengal. All the children less than 15 years of age, attending in Unit II outpatient department were selected by complete enumeration method for duration of one year (January-December 2010). Distribution of association was analyzed by Chi-square test and difference between two proportions was calculated by z test for proportions. The common ocular morbidity were refractive errors (23.67%) followed by allergic conjunctivitis (17.23%), infection of the eye and adnexa (15.13%), ocular trauma (12.74%), and congenital eye diseases (13.59%). Majority of ocular morbidity is treatable and need early attention through eye screening cum intervention program beginning right from the childhood.

Tanima D.,Rg Kar Medical College
The Journal of the Association of Physicians of India | Year: 2011

Extrapyramidal syndrome is an uncommon sequelae of acute organophosphorous (OP) poisoning. It is a manifestation of the intermediate syndrome described in OP poisoning. It may or may not be associated with neuroimaging changes in the striatum. We present a case of acute OP poisoning with interesting positive CT scan findings.

Sen K.,Rg Kar Medical College
Nepal Medical College journal : NMCJ | Year: 2012

Stroke or cerebro-vascular disease is one of the most important causes of high morbidity and mortality throughout the world. Stroke in young individuals poses a major problem as these individuals are the earning members of the family. Ischemic strokes are increasingly being attributed to causes other than athero-thrombotic disease. Protein S deficiency is a disorder with increased risk of venous thrombosis. Our patient, 19 years old lady presented with haemorrhagic venous infarction in right temporo-occipito-parietal region with right sided lateral sinus thrombosis.

Natural arsenic pollution is a major global health problem. The two worst affected areas e Bangladesh and West Bengal, India. Arsenic is a well-documented human carcinogen that affects many organs including the skin. The authors sought to find out the clinical patterns of different malignant and premalignant conditions associated with chronic arsenicosis from drinking contaminated ground water in a group of patients from eastern India. This was a clinical observational study. Patients with chronic arsenicoses with suspected cutaneous malignancies for whom dermatology service was sought were enrolled in the study. A total of 24 patients (male to female ratio, 11:1; age range, 32-71 years; mean age, 52.2 years) were evaluated. Squamous cell carcinoma (SCC) was the commonest malignancies in our series, seen in 10 (41.7%) patients. This was followed by Bowen's disease (9 [37.5%]) and basal cell carcinoma (8 [33.3%]). Three patients (12.5%) had > 1 type of cutaneous malignancies. Multicentric lesions were seen in 3 cases. The most common site of involvement was the chest (8 [33.3%]). No statistically significant correlation was found between number of lesions and arsenic content in the hairs and nails of the patients.

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