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Mostoles, Spain

King Juan Carlos University is a top Spanish public research university located in the Southern area of the Community of Madrid , with four campuses at Móstoles, Alcorcón, Vicálvaro and Fuenlabrada.It is named after king Juan Carlos I of Spain. It was created in 1996 and has the Latin motto Non nova, sed nove . With 35,877 students, it is the third biggest public university in the Community of Madrid. Wikipedia.


Fernandez-de-las-Penas C.,Rey Juan Carlos University
Current rheumatology reports | Year: 2014

Trigger points (TrP) are hyperirritable spots in a taut band of a skeletal muscle, which usually have referred pain. There is controversy over whether TrP are a peripheral or central nervous system phenomenon. Referred pain, the most characteristic sign of TrP, is a central phenomenon initiated and activated by peripheral sensitization, whereby the peripheral nociceptive input from the muscle can sensitize dorsal horn neurons that were previously silent. TrP are a peripheral source of nociception, and act as ongoing nociceptive stimuli contributing to pain propagation and widespread pain. Several studies support the hypothesis that TrP can induce central sensitization, and appropriate TrP treatment reduces central sensitization. In contrast, preliminary evidence suggests that central sensitization can also promote TrP activity, although further studies are needed. Proper TrP management may prevent and reverse the development of pain propagation in chronic pain conditions, because inactivation of TrP attenuates central sensitization. Source


Ibarz B.,New York University | Casado J.M.,University of Seville | Sanjuan M.A.F.,Rey Juan Carlos University
Physics Reports | Year: 2011

Ever since the pioneering work of Hodgkin and Huxley, biological neuron models have consisted of ODEs representing the evolution of the transmembrane voltage and the dynamics of ionic conductances. It is only recently that discrete dynamical systems-also known as maps-have begun to receive attention as valid phenomenological neuron models. The present review tries to provide a coherent perspective of map-based biological neuron models, describing their dynamical properties; stressing the similarities and differences, both among them and in relation to continuous-time models; exploring their behavior in networks; and examining their wide-ranging possibilities of application in computational neuroscience. © 2010 Elsevier B.V. Source


de-la-Llave-Rincon A.I.,Rey Juan Carlos University
Discovery medicine | Year: 2012

In recent years, knowledge about the etiological mechanisms of carpal tunnel syndrome (CTS) has evolved significantly, allowing for a better understanding of this pain syndrome. Some studies have demonstrated that patients with CTS exhibit sensory symptoms not only within the areas innervated by the median nerve but also in extra-median regions, i.e., forearm or shoulder. It has also been demonstrated that patients with CTS may exhibit widespread pressure hypersensitivity and generalized thermal hyperalgesia, but not hypoesthesia, which is not related to electro-diagnostic findings. In addition, fine motor control and pinch grip force disturbances have been found to be commonly observed in this patient population. All these data suggest that central sensitization mechanisms are involved in the somato-sensory and motor disturbances found in CTS, probably related to cortical plastic changes. The presence of sensitization mechanisms could play an important role in the development of bilateral sensory symptoms in CTS and also can determine the therapeutic strategies for this condition. We propose that therapeutic interventions applied to individuals with CTS should include approaches that would modulate nociceptive barrage into the central nervous system. Source


Garcia-Velasco J.A.,Rey Juan Carlos University
Fertility and Sterility | Year: 2012

Agonist triggering combined with oocyte vitrification and ET in a subsequent natural cycle avoids ovarian hyperstimulation syndrome in patients at risk and shows excellent cycle outcome. © 2012 American Society for Reproductive Medicine, Published by Elsevier Inc. Source


Medina-Gomez G.,Rey Juan Carlos University
Best Practice and Research: Clinical Endocrinology and Metabolism | Year: 2012

Excess of adipose tissue is accompanied by an increase in the risk of developing insulin resistance, type 2 diabetes (T2D) and other complications. Nevertheless, total or partial absence of fat or its accumulation in other tissues (lipotoxicity) is also associated to these complications. White adipose tissue (WAT) was traditionally considered a metabolically active storage tissue for lipids while brown adipose tissue (BAT) was considered as a thermogenic adipose tissue with higher oxidative capacity. Nowadays, WAT is also considered an endocrine organ that contributes to energy homeostasis. Experimental evidence tends to link the malfunction of adipose mitochondria with the development of obesity and T2D. This review discusses the importance of mitochondrial function in adipocyte biology and the increased evidences of mitochondria dysfunction in these epidemics. New strategies targeting adipocyte mitochondria from WAT and BAT are also discussed as therapies against obesity and its complications in the near future. © 2012 Elsevier Ltd. All rights reserved. Source

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