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Alexander S.,University of Bristol | De Vos W.M.,University of Bristol | Castle T.C.,Revolymer | Cosgrove T.,University of Bristol | Prescott S.W.,University of Bristol
Langmuir | Year: 2012

The micellization of Pluronic triblock copolymers (P103, P123, and L43) in the presence of flurbiprofen at different pH was studied by small-angle neutron scattering (SANS), pulsed-field gradient stimulated-echo nuclear magnetic resonance (PFGSE-NMR), and surface tension measurements. Addition of flurbiprofen to the Pluronic at low pH leads to an increase in the fraction of micellization, aggregation number, and the core radius of the micelles. However, changing the pH to above the pKa of flurbiprofen in an ethanol/water mixture (∼6.5) reduces the fraction of micellization and results in a weaker interaction between the drug and micelles due to the increased drug solubility in aqueous solution. © 2012 American Chemical Society.


Alexander S.,University of Bristol | Cosgrove T.,University of Bristol | Prescott S.W.,University of Bristol | Castle T.C.,Revolymer
Langmuir | Year: 2011

Pulsed-field gradient stimulated-echo nuclear magnetic resonance (NMR) and surface tension measurements have been used to study the effect of drug addition on the micellization behavior of pluronic triblock copolymers (P103, P123, and L43). The addition of 0.6 wt % flurbiprofen to Pluronic P123 and P103 solutions reduced their cmc and promoted micellization. Also, a substantial increase in the hydrodynamic radius of Pluronic P103 from 5 to 10 nm was observed, along with an increased fraction of polymer micellized, demonstrating that the polymers solubilize this nonsteroidal anti-inflammatory drug. © 2011 American Chemical Society.


Patent
Revolymer | Date: 2010-11-29

A cosmetic composition including: (i) at least one amphiphilic copolymer; and (ii) one or more cosmetically acceptable diluents, excipients or carriers; wherein the amphiphilic copolymer is selected from the group consisting of a graft copolymer including a hydrophobic straight or branched chain carbon-carbon backbone having at least one hydrophilic side chain attached thereto; a graft copolymer comprising a hydrophilic straight or branched chain backbone having at least one hydrophobic side chain attached thereto; a block copolymer including at least one hydrophilic block and at least one hydrophobic block in a straight or branched chain backbone; and a cross-linked/network copolymer.


Patent
Revolymer | Date: 2012-04-13

The present invention relates to a novel composite including one or more core units having an ionic strength-responsive hydroxyl-functional vinylic co-polymeric coating, to a process for the preparation of such a composite, to formulations including the same and their use in a variety of industrial applications.


Patent
Revolymer | Date: 2010-10-28

A composite includes: one or more core units comprising a bleach activating agent; and an alkali soluble polymer coating on the surface of said one or more core units.

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