Los Altos Hills, CA, United States
Los Altos Hills, CA, United States
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Some aspects of the invention provide for a method of treating a patient having glaucoma, a non-hereditary optic neuropathy, steroid-induced oxidative stress, or steroid-induced oxidation-related disorders, comprising identifying a patient having a non-hereditary optic neuropathy or steroid-induced oxidative stress or steroid-induced oxidation-related disorders and in need of treatment; repeatedly administering a polyunsaturated substance to the patient or the patients tissue, wherein the polyunsaturated substance is chemically modified such that one or more bonds is stabilized against oxidation; wherein following said administration, the polyunsaturated substance or a polyunsaturated metabolite thereof comprising said one or more chemical modifications is incorporated into the patients body or the patients tissue.


A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is ^(2)H and/or at least one C atom is ^(13)C. The nutrient is thus protected from, inter alia, active oxygen species.


Patent
Retrotope | Date: 2014-01-27

Compounds containing nucleic acid bases or their precursors modified by enrichment at specific sites with heavy stable isotopes of elements naturally present at those sites in minute amount are useful for the treatment of diseases characterized by altered gene expression and altered pattern of epigenomic control. These compounds, when used as nutrients or in other medicinal application methods, can alter the DNA methylation pattern in a simple way through the well-understood mechanism of kinetic isotope effect (KIE). This effect could also be useful for modifying methylation kinetics in stem cell technology, cloning and as disease therapeutics.


Some aspects of the invention provide for a method of treating Alzheimers Disease, Mild Cognitive Impairment, Frontotemperal Dementia, Amyotrophic Lateral Sclerosis and/or Multiple Sclerosis using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.


A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is ^(2)H and/or at least one C atom is ^(13)C. The nutrient is thus protected from, inter alia, active oxygen species.


Some aspects of the invention provide for essential fatty acids which are substituted in specific positions to slow down oxidative damage by Reactive Oxygen Species (ROS), and to suppress the rate of consequent formation of reactive products, for the purpose of preventing or reducing the damage associated with oxidative stress associated diseases such as neurological diseases and age-related macular degeneration (AMD).


Some aspects of the invention provide for a method of treating Impaired Energy Processing Disorders and Mitochondrial Deficiencies using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.


Patent
Retrotope | Date: 2012-04-24

Some aspects of the invention provide for a method of treating Wet and/or Dry Age-related Macular Degeneration, Retinitis Pigmentosa, Diabetic Retinopathy, cataracts, and/or Stargardt Disease using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.


Patent
Retrotope | Date: 2012-04-24

Some aspects of the invention provide for a method of treating hepatic disorders, lipidemias and cardiac-related risk factors using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.


A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is ^(2)H and/or at least one C atom is ^(13)C. The nutrient is thus protected from, inter alia, active oxygen species.

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