Yogyakarta, Indonesia

Respati University of Yogyakarta

www.respati.ac.id
Yogyakarta, Indonesia

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Zakiyah Z.,Respati University of Yogyakarta | Jayanti Y.D.,Dharma Husada Midwifery Academy | Nurdiana N.,Brawijaya University | Dwijayasa P.M.,Brawijaya University
Journal of Taibah University Medical Sciences | Year: 2017

Objectives: Our study aimed to evaluate the effects of ferrous sulphate supplementation on iron regulation and homeostasis in pregnant rats. Methods: Twenty-four pregnant rats were divided into four groups; including the control (untreated) pregnant group and the pregnant groups that received ferrous sulphate starting at the 1st trimester (1st day of pregnancy), 2nd trimester (8th day of pregnancy), and 3rd trimester (15th day of pregnancy). Ferrous sulphate was administered orally with an oral gavage until birth. Serum iron and total iron binding capacity were measured by a colorimetric method. Hepcidin levels were measured using an immunoassay method. Results: The serum iron, transferrin saturation, and hepcidin levels were significantly increased in the group given iron sulphate in the 3rd trimester compared with the 2nd or 1st trimesters and in the 3rd trimester compared with the 2nd trimester (p < 0.05). The total iron binding capacity levels were significantly decreased in the group that received iron sulphate in the 1st trimester compared with the 2nd or 3rd trimesters (p < 0.05). The total iron binding capacity levels were also significantly decreased in the group that received iron sulphate in the 2nd trimester compared with the 3rd trimester (p < 0.05). Conclusions: Early administration of ferrous sulphate in pregnancy leads to higher levels of serum iron, transferrin saturation, and hepcidin. © 2017 The Authors.


Soni M.,Loughborough University | Rahardjo T.B.W.,Respati University of Yogyakarta | Soekardi R.,Respati University of Yogyakarta | Sulistyowati Y.,Respati University of Yogyakarta | And 5 more authors.
Maturitas | Year: 2014

Neuroprotective effects of phytoestrogen compounds (found in soy) have been demonstrated in animal research and cell culture studies. In particular, phytoestrogens have been shown to reduce Alzheimer's Disease (AD) related pathology, potentially alleviating risk of AD progression. In addition to their antioxidant properties, soy products also have the ability to affect cognition via interaction with estrogen receptors. However, observational studies and randomised controlled trials in humans have resulted in inconclusive findings within this domain. There are several possible reasons for these discrepant data. Studies which report no effect of phytoestrogens on cognition have mainly been carried out in European cohorts, with an average low dietary consumption. In contrast, investigation of Asian populations, with a higher general intake of tofu (a non-fermented soy product) have shown negative associations with cognitive function in those over the age of 65. Consideration of type of soy product is important, as in the latter sample, protective effects of tempe (fermented soy) were also observed. Limited data provide evidence that effects of phytoestrogens on cognition may be modified by dosage, duration of consumption and cognitive test used. Additionally, characteristics of the study population including age, gender, ethnicity and menopausal status appear to be mediating variables. Phytoestrogen treatment interventions have also shown time-limited positive effects on cognition. These findings are consistent with estrogen treatment studies, where initial positive short-term cognitive effects may occur, which reverse with long-term continuous use in elderly women. Well controlled, large scale studies are needed to assess the effects of phytoestrogens on the aging brain and provide further understanding of this association. © 2013 Elsevier Ireland Ltd. All rights reserved.


Soni M.,Loughborough University | White L.R.,Pacific Health Research and Education Institute | Kridawati A.,Respati University of Yogyakarta | Bandelow S.,Respati University of Yogyakarta | Hogervorst E.,Loughborough University
Journal of Steroid Biochemistry and Molecular Biology | Year: 2016

It is predicted that around 20% of the worlds population will be age 60 or above by 2050. Prevalence of cognitive decline and dementia is high in older adults and modifiable dietary factors may be able to reduce risk for these conditions. Phytoestrogens are bioactive plant chemicals found in soy, which have a similarity in structure to natural estradiol (the most abundant circulating estrogen). This structural likeness enables phytoestrogens to interact with estrogen receptors in the brain, potentially affecting cognition. However, findings in this domain are largely inconsistent, with approximately 50% of studies showing positive effects of phytoestrogens on cognition and the other half resulting in null/negative findings. This paper provides an updated review of the relationship between consumption of phytoestrogens and risk for cognitive decline and/or dementia. In particular, possible mediators were identified to explain discrepant findings and for consideration in future research. A case can be made for a link between phytoestrogen consumption, thyroid status and cognition in older age, although current findings in this area are very limited. Evidence suggests that inter-individual variants that can affect phytoestrogen bioavailability (and thus cognitive outcome) include age and ability to breakdown ingested phytoestrogens into their bioactive metabolites. Factors of the study design that must be taken into account are type of soy product, dosage, frequency of dietary intake and type of cognitive test used. Guidelines regarding optimal phytoestrogen dosage and frequency of intake are yet to be determined. © 2015 Elsevier Ltd. All rights reserved.


Afriani Y.,Respati University of Yogyakarta | Putri K.R.,Gadjah Mada University | Penggalih M.H.S.T.,Gadjah Mada University | Kandarina I.,Gadjah Mada University | Sofro Z.M.,Gadjah Mada University
Pakistan Journal of Nutrition | Year: 2015

Banana isotonic drink is a potential beverage which has positive effect to maintain blood circulation. To make an improvement of product, clinical trials must be done in humans to know the effects of rehydration based on electrolyte analysis. This study used cross-over design with 7 days of washed out periods. Sixteen respondents, aged up to 20 years old and passed the selection of orthostatic test, were involved in this study. Changes in urine and blood electrolyte levels were checked before and after intervention. Electrolyte, include sodium, chloride and potassium, were measured using Easylyte. Data were analyzed with paired t-test and independent sample test. There were significant differences of urine level of chloride and sodium (p<0.05) after consumption plain water and banana isotonic drink. However, there was no significant difference (p>0.05) in urine level of potassium. Urine electrolyte decreased in all group after intervention. Meanwhile, potassium level increased after consumption banana isotonic drink. There were significant differences of chloride blood level (p<0.05) between plain water and banana isotonic drink. There were no significant differences (p>0.05) in blood level of potassium and sodium. Blood level of sodium and chloride decreased in all group. Meanwhile, potassium level increased after consumption banana isotonic drink. Banana isotonic drink was effective to maintain level of electrolyte in body by decreasing the level of electrolyte in urine output and improve potassium level. © Asian Network for Scientific Information, 2015.


PubMed | Loughborough University, Pacific Health Research and Education Institute and Respati University of Yogyakarta
Type: | Journal: The Journal of steroid biochemistry and molecular biology | Year: 2016

It is predicted that around 20% of the worlds population will be age 60 or above by 2050. Prevalence of cognitive decline and dementia is high in older adults and modifiable dietary factors may be able to reduce risk for these conditions. Phytoestrogens are bioactive plant chemicals found in soy, which have a similarity in structure to natural estradiol (the most abundant circulating estrogen). This structural likeness enables phytoestrogens to interact with estrogen receptors in the brain, potentially affecting cognition. However, findings in this domain are largely inconsistent, with approximately 50% of studies showing positive effects of phytoestrogens on cognition and the other half resulting in null/negative findings. This paper provides an updated review of the relationship between consumption of phytoestrogens and risk for cognitive decline and/or dementia. In particular, possible mediators were identified to explain discrepant findings and for consideration in future research. A case can be made for a link between phytoestrogen consumption, thyroid status and cognition in older age, although current findings in this area are very limited. Evidence suggests that inter-individual variants that can affect phytoestrogen bioavailability (and thus cognitive outcome) include age and ability to breakdown ingested phytoestrogens into their bioactive metabolites. Factors of the study design that must be taken into account are type of soy product, dosage, frequency of dietary intake and type of cognitive test used. Guidelines regarding optimal phytoestrogen dosage and frequency of intake are yet to be determined.

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